Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice

Zhou, Xingqin; Chen, Quancheng; Hu, Xindai; Mao, Shishi; Kong, Yanyan

doi:10.1016/j.bbr.2013.10.025

Cited by 16 publications

(3 citation statements)

References 60 publications

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“…1 ). The results are supported by previous studies, using MK-801 treatment in mice 54 and hypoxia treatment in rats 55 , which proved that PQQ would prevent the cognitive deficit resulting from the oxidative stress.…”

Section: Discussionsupporting

confidence: 86%

“…Some studies had already confirmed that PQQ prevents oxidative damage in the brain and reduces the cognitive deficit caused by oxidative stress in rats during aging 52 . In our previous study, we found that PQQ may be converted into a derivative by binding with amino acid, which is beneficial to several pathological processes 53 , 54 . However, which derivative promotes antioxidant in aging brain and the underlying mechanism is yet unclear.…”

Section: Discussionmentioning

confidence: 99%

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PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse

Zhou¹,

Yao

Peng³

et al. 2018

Sci Rep

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Oxidative stress is known to be associated with various age-related diseases. D-galactose (D-gal) has been considered a senescent model which induces oxidative stress response resulting in memory dysfunction. Pyrroloquinoline quinone (PQQ) is a redox cofactor which is found in various foods. In our previous study, we found that PQQ may be converted into a derivative by binding with amino acid, which is beneficial to several pathological processes. In this study, we found a beneficial glutamate mixture which may diminish neurotoxicity by oxidative stress in D-gal induced mouse. Our results showed that PQQ may influence the generation of proinflammatory mediators, including cytokines and prostaglandins during aging process. D-gal-induced mouse showed increased MDA and ROS levels, and decreased T-AOC activities in the hippocampus, these changes were reversed by PQQ supplementation. Furthermore, PQQ statistically enhanced Superoxide Dismutase SOD2 mRNA expression. PQQ could ameliorate the memory deficits and neurotoxicity induced by D-gal via binding with excess glutamate, which provide a link between glutamate-mediated neurotoxicity, inflammation and oxidative stress. In addition, PQQ reduced the up-regulated expression of p-Akt by D-gal and maintained the activity of GSK-3β, resulting in a down-regulation of p-Tau level in hippocampus. PQQ modulated memory ability partly via Akt/GSK-3β pathway.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse

Zhou¹,

Yao

Peng³

et al. 2018

Sci Rep

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“…To assess if such AIS plasticity actually occur in schizophrenia, we used postnatal MK-801 (an NMDA receptor antagonist) model. Transient exposure to MK-801 during the neonatal period causes behavioral changes in rodents such as hyperlocomotion, stereotyped behavior, sensorimotor gating, and cognitive deficits representing schizophrenia-like symptoms (Feinstein & Kritzer, 2013;Furuie, Yamada, & Ichitani, 2013;Nozari, Shabani, Hadadi, & Atapour, 2014, Nozari, Mansouri, Shabani, Nozari, & Atapour, 2015Nozari, Shabani, Farhangi, Mazhari, & Atapour, 2015;Zhou, Chen, Hu, Mao, & Kong, 2013). Underlying these behavioral changes are a decrease in the function of different neurotransmitter systems such as glutamatergic, dopaminergic, and GABAergic system (Abekawa, Ito, Nakagawa, & Koyama, 2007;Hoftman & Lewis, 2011;Jones, Corbin, & Huntsman, 2014;Weinstein et al, 2016).…”

mentioning

confidence: 99%

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

Nozari

Suzuki

Rosa

et al. 2016

Developmental Psychobiology

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Plasticity of the axon initial segment (AIS) is a newly discovered type of structural plasticity that regulates cell excitability. AIS plasticity has been reported to happen during normal development of neocortex and also in a few pathological conditions involving disruption of the inhibition/excitation balance. Here we report on the impact of early environmental interventions on structural plasticity of AIS in the mouse neocortex. C57BL/6 mice were raised

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Postnatal MK-801 treatment of female rats impairs acquisition of working memory, but not reference memory in an eight-arm radial maze; no beneficial effects of enriched environment

et al. 2015

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Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice

Cited by 16 publications

References 60 publications

PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse

PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

Postnatal MK-801 treatment of female rats impairs acquisition of working memory, but not reference memory in an eight-arm radial maze; no beneficial effects of enriched environment

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