Pyrroloquinoline quinone regulates glycolipid metabolism in the jejunum <i>via</i> inhibiting AMPK phosphorylation of weaned pigs

Huang, Caiyun; Shi, Chuanxin; Li, Zhe; Wang, Wenhui; Ming, Dongxu; Gao, Youjun; Liu, Hu; Ma, Xi; Wang, Fenglai

doi:10.1039/d2fo00281g

Cited by 5 publications

(2 citation statements)

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“…Inflammation induced by LPS often causes liver and intestine injury, and then resultant growth retardation in piglets around weaning. Dietary PQQ supplementation in weaned piglets could decrease intestinal inflammatory injury (16,23) and regulate redox status and glycolipid metabolism as our previous studies (15,24) . However, few reports extend those results and focused on the effect of PQQ for liver injury in weaned piglets challenged with LPS.…”

Section: Discussionmentioning

confidence: 50%

“…We have reported recently that diet supplemented with 3 mg/kg of diet PQQ decreases expression of inflammatory factors (14) and regulates glycolipid metabolism via AMPK phosphorylation (15) in intestine of piglets during weaning. What is more, diet supplemented with 3 mg/kg PQQ attenuated inflammatory injury by inhibiting NF-κB signalling in jejunum of piglets challenged with enterotoxigenic Escherichia coli (16) .…”

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confidence: 99%

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Pyrroloquinoline quinone supplementation attenuates inflammatory liver injury by STAT3/TGF-β1 pathway in weaned piglets challenged with lipopolysaccharide

Huang,

Yu,

Shi

et al. 2023

Br J Nutr

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This study is aimed to evaluate the effect and underling mechanism of dietary supplementation with pyrroloquinoline quinone disodium (PQQ) on improving inflammatory liver injury in piglets challenged with lipopolysaccharide (LPS). A total of 72 crossbred barrows were allotted into 4 groups as following: the CTRL group (basal diet + saline injection); the PQQ group (3 mg/kg PQQ diet + saline injection); the CTRL + LPS group (basal diet + LPS injection); and the PQQ + LPS group (3 mg/kg PQQ diet + LPS injection). On d 7, 11 and 14, piglets were challenged with LPS or saline. Blood was sampled at 4 hours after the last LPS injection (d 14), then the piglets were slaughtered and liver tissue were harvested. The results showed that the hepatic morphology was improved in the PQQ + LPS group compared with the CTRL + LPS group. PQQ supplementation decreased level of serum inflammatory factors, AST, ALT, and increased HDL-C concentration in piglets challenged with LPS; piglets in PQQ + LPS group had lower liver mRNA level of inflammatory factors and protein level of α-SMA than in CTRL + LPS group; Besides, mRNA expression of STAT3/TGF-β1 pathway and protein level of p-STAT3(Tyr 705) were decreased, and mRNA level of PPARα and protein expression of p-AMPK in liver were increased in PQQ + LPS group compared to CTRL + LPS group (P < 0.05). In conclusion, dietary supplementation with PQQ alleviated inflammatory liver injury might partly via inhibition of the STAT3/TGF-β1 pathway in piglets challenged with LPS.

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