Pyrus biossieriana Buhse leaf extract: An antioxidant, antihyperglycaemic and antihyperlipidemic agent

Shahaboddin, Mohammad Esmaeil; Pouramir, Mahdi; Moghadamnia, Ali Akbar; Parsian, Hadi; Lakzaei, Mostafa; Mir, Hamed

doi:10.1016/j.foodchem.2010.12.069

Cited by 45 publications

(30 citation statements)

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“…Bear-berry is one of the few known naturally occurring anti-microbial plants and is due to the presence of ARB. ARB has a variety of pharmacological and therapeutic properties, including anti-inflammatory 8 , antiviral 9 , antihyperglycemic 10 and antioxidant activity 11 . ARB will be an excellent phytomedicine for the treatment of myocardial infarction due to its antioxidant and anti-inflammatory properties.…”

Section: Ijpsr (2020) Volume 11 Issue 3 (Research Article)mentioning

confidence: 99%

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The present study was designed to investigate the cardioprotective effect of Arbutin (ARB) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac and hepatic markers, antioxidant defense system, lipid peroxidation products and histopathological changes. Rats were pretreated with ARB (25 and 50 mg/kg BW) for 21 days. After pretreatment, ISO (60 mg/kg BW) was administered subcutaneously into the rats at an interval of 24 h for 2consecutive days to induce MI. In the present study ISO-induced myocardial damage was indicated by the increased heart weight to body weight ratio and the increased activity of marker enzymes such as CK, CK-MB, ALT, AST, LDH, and the elevated levels of troponin T and I in the serum. In addition, the levels of lipid peroxidation products such as TBARS, CDs, and LHPs were significantly increased in the plasma and heart tissue of ISO rats. Activities of enzymic antioxidants such as SOD, CAT, GPx, GST and the non-enzymic antioxidants like vitamin C, vitamin E and reduced glutathione (GSH) were decreased in the erythrocytes, plasma and heart tissues of the ISOadministered rats. Histopathological observations substantiate with the biochemical parameters. The 50 mg/kg BW of ARB was more pronounced than the 25 mg/kg BW and brought back all the above parameters to near normal. ARB ameliorates myocardial damage caused by ISO in rats and provides cardioprotective effect by scavenging the free radicals, restoring the endogenous antioxidants, preserving histopathology of the myocardium and by improving the cardiac function.

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Section: Ijpsr (2020) Volume 11 Issue 3 (Research Article)mentioning

confidence: 99%

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“…It also exists in the leaves of various plant species including bearberry (Arctostaphylos uva-ursi) and Telka (Pyrus Biossierana Bushe). Bearberry is with 20 % arbutin, and uva ursi leaf standard with 10 % arbutin (11,12). It has been shown that arbutin is effective in the repulsion of kidney stones and possess antibacterial properties; it can be used as a cure for the urinary tract infections (13).…”

Section: Introductionmentioning

confidence: 99%

Is arbutin an effective antioxidant for the discount of oxidative and nitrosative stress in Hep-G2 cells exposed to tert-butyl hydroperoxide?

Seyfizadeh¹,

Tazehkand²,

Palideh³

et al. 2019

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AIM: Oxidative and nitrosative stress triggers an extensive damage to the tissues. Many herbal and chemical medicines have claimed to possess antioxidant properties. Arbutin exists in some plants such as Pyrus Biossierana Bushe. In this study, an inhibitory effect of arbutin against tert-butyl hydroperoxide induced cytotoxicity was studied using SYTOX TM Green assay for cell viability. The antioxidant effects of arbutin on the generation of malondialdehyde, nitric oxide, activity of oxidative enzyme (Superoxide dismutase and catalyze) and the amount of total thiol in Hep-G2 cells exposed to tert-butyl hydroperoxide were evaluated. METHODS: Hep-G2 cells were cultured in 24-well plates. After 24 hours, the cells were pretreated with the arbutin at different concentrations (0, 100 and 150 μM). 24 hours later, tert-butyl hydroperoxide at different concentrations (0, 150, 200 and 250 μM) was added into the culture media. RESULTS: Arbutin was able to decrease malondialdehyde and nitric oxide concentrations in arbutin treated group in comparison with the control group (p < 0.00001). The catalase and superoxide dismutase enzymes in these cells were signifi cantly decreased in a dose depend manner in the presence of arbutin in comparison with the control group (p < 0.00001). In addition, arbutin was capable of increasing the tert-butyl hydroperoxide mediated reduction in the total thiol amount in comparison with the control group (p < 0.00001.) CONCLUSION: Our investigation demonstrated that tert-butyl hydroperoxide evoked a reactive oxygen and nitrogen species overproduction in Hep-G2 cells. The cells treated with arbutin showed a dose-dependent reduction of tert-butyl hydroperoxide induced reactive oxygen and nitrogen species generation (Fig. 6, Ref. 34). Text in PDF www.elis.sk.

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“…Its leaves contain high levels of arbutin, a glycosylated hydroquinone that inhibits tyrosinase. This plant has a variety of pharmacological and therapeutic properties, including anti-inflammatory, antiviral, anti-hyperglycemic, anti-hyperlipidemic, and antioxidant activity (10). It has been shown to scavenge free radicals (11), be gastroprotective (12), and exhibit alpha-glycosidase and alpha-amylase inhibitory activity (13).…”

Section: Introductionmentioning

confidence: 99%