Pyruvate and lactate excretion in diabetes mellitus after sodium lactate.

Anderson, J.; Thomas, Wendy; Tomlinson, R. W. S.

doi:10.1136/bmj.2.5522.1114

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Unfortunately some diabetics when ketotic have a high blood lactate level (Walker, Linton & Thomson, 1960;Anderson, Thomas & Tomlinson, 1966), and furthermore oxygen may not be readily available for conversion of lactate to bicarbonate which is the chief buffer of plasma. For efficient and safe administration of intravenous sodium bicarbonate use must be made of the Astrup apparatus for rapid estimations of pH and Pco2 and calculation of the base deficit (Astrup et al, 1960).…”

Section: Discussionmentioning

confidence: 99%

The management of acid-base balance in children with diabetic acidosis

Kuzemko

Fielding

Hudson

1969

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 99%

The management of acid-base balance in children with diabetic acidosis

Kuzemko

Fielding

Hudson

1969

Postgraduate Medical Journal

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“…Sorbit und Xylit. Diabetes mellitus.Bei gut eingesteltten diabetischen Patienten liegen die Blut-Lactatspiegel gew6hnlich im Normbereich[3]. Neben den bekannten Nebenwirkungen von Xylit, wie dem Anstieg der Harn-s~iure, wurden auch metabolische Azidosen und Hyperlactat/imien unter Xylitinfusionen beobachtet.…”

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Lactat-Azidose ? Eine m�gliche Komplikation der Buformin-Therapie

et al. 1978

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Lactic acidosis is defined as a state of metabolic acidosis (arterial pH below 7.36) due to an increase in the blood concentration of lactate above 2 mEq/l. Lactic acidosis may occur under a variety of conditions; the biguanide-induced lactic acidosis is due to the toxic effects of biguanides (buformin, metformin, phenformin). The clinical picture is characterized by the occurrence of disturbances of consciousness, severe acidosis with Kussmaul's respiration, shock, hypothermia and in about 30% of all cases hypoglycemia. Apart from the general principles of intensive medical care, therapy should comprise correction of the acid-base-disturbances and elimination of the offending biguanide. The efficacy of hemodialysis in the treatment of biguanide-induced lactic acidosis is difficult to evaluate. By a more sensible use of biguanides, lactic acidosis secondary to drug administration should become a rare event.

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Lactic acidosis

Oliva¹

1970

The American Journal of Medicine

221

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Pyruvate and lactate excretion in diabetes mellitus after sodium lactate.

Cited by 7 publications

References 6 publications

The management of acid-base balance in children with diabetic acidosis

The management of acid-base balance in children with diabetic acidosis

Lactat-Azidose ? Eine m�gliche Komplikation der Buformin-Therapie

Lactic acidosis

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