Q-band electron paramagnetic resonance dosimetry in tooth enamel: biopsy procedure and determination of dose detection limit

Romanyukha, A.; Trompier, F.; Reyes, Ricárdo

doi:10.1007/s00411-013-0511-8

Cited by 27 publications

(24 citation statements)

References 14 publications

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“…Ex vivo EPR dosimetry on nails and hair remains very attractive, but it is not yet possible to detect with accuracy doses below 5 Gy (Romanyukha et al 2014;Trompier et al 2014). Ex vivo EPR on enamel with mini-biopsy has been used for radiation accident dosimetry with success and can be considered as a valuable tool for triage, but it required specific instrumentation not available in most of EPR laboratories (Romanyukha et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Overview of physical dosimetry methods for triage application integrated in the new European network RENEB

Trompier

Burbidge

Bassinet

et al. 2016

International Journal of Radiation Biology

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Physically-based dosimetry techniques present high capacity, new possibilities for accident dosimetry, especially in the case of large-scale events. Some of the techniques applied can be considered as operational (e.g. OSL on Surface Mounting Devices [SMD]) and provide a large increase of measurement capacity for existing networks. Other techniques and devices currently undergoing validation or development in Europe could lead to considerable increases in the capacity of the RENEB accident dosimetry network.

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Section: Discussionmentioning

confidence: 99%

Overview of physical dosimetry methods for triage application integrated in the new European network RENEB

Trompier

Burbidge

Bassinet

et al. 2016

International Journal of Radiation Biology

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“…Application of Q-band spectroscopy can also improve the method by giving the possibility to use samples with smaller masses (Romanyukha et al 2014). …”

Section: Discussionmentioning

confidence: 99%

Internal in vitro dosimetry for fish using hydroxyapatite-based EPR detectors

Иванов

Shishkina

Osipov

et al. 2015

Radiat Environ Biophys

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A number of aquatic ecosystems were exposed to ionizing radiation as a result of the activities of the Mayak Production Association in the Southern Urals, former Soviet Union, in the 1950s. Currently, fishes inhabiting contaminated lakes are being actively studied. These investigations need dosimetric support. In the present paper the results of a pilot study for elaborating an EPR dosimeter which can be used for internal dosimetry in vitro are described. Biological hydroxyapatite is proposed here to be used as a detecting substance. More specifically, small hydroxyapatite grains are proposed for use as point detectors fixed in a solid matrix. After having been pelletized, the detectors were covered by Mylar and placed in the body of a fish to be stored in the fridge for several months. Application of the detectors for internal fish dosimetry demonstrated that the enamel sensitivity is sufficient for passive detection of ionizing radiation in fishes inhabiting contaminated lakes in the Southern Urals.

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“…An alternate approach to dosimetry uses methods that are physically based, i.e., they are based on assaying the dose-dependent chemical/physical responses in calcified or hardened tissues such as in bone, teeth or nails (finger- and toenails) or in solid materials (cell phone components, salts, glass, etc.) (Ainsbury et al 2016, Bailiff et al 2016, McKeever and Sholom 2016, Romanyukha et al 2014a, Swartz et al 2014). Physically-based biodosimetry methods rely on measuring dose dependent chemical changes that occur in biological materials (typically hardened or calciferous biomaterial such as teeth or nails) as a means of estimating radiation dose to an individual (Swartz et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry

et al. 2018

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Instrumentation and application methodologies for rapidly and accurately estimating individual ionizing radiation dose are needed for on-site triage in a radiological/nuclear event. One such methodology is an in vivo X-band, electron paramagnetic resonance, physically based dosimetry method to directly measure the radiation-induced signal in fingernails. The primary components under development are key instrument features, such as resonators with unique geometries that allow for large sampling volumes but limit radiation-induced signal measurements to the nail plate, and methodological approaches for addressing interfering signals in the nail and for calibrating dose from radiation-induced signal measurements. One resonator development highlighted here is a surface resonator array designed to reduce signal detection losses due to the soft tissues underlying the nail plate. Several surface resonator array geometries, along with ergonomic features to stabilize fingernail placement, have been tested in tissue-equivalent nail models and in vivo nail measurements of healthy volunteers using simulated radiation-induced signals in their fingernails. These studies demonstrated radiation-induced signal detection sensitivities and quantitation limits approaching the clinically relevant range of ≤ 10 Gy. Studies of the capabilities of the current instrument suggest that a reduction in the variability in radiation-induced signal measurements can be obtained with refinements to the surface resonator array and ergonomic features of the human interface to the instrument. Additional studies are required before the quantitative limits of the assay can be determined for triage decisions in a field application of dosimetry. These include expanded in vivo nail studies and associated ex vivo nail studies to provide informed approaches to accommodate for a potential interfering native signal in the nails when calculating the radiation-induced signal from the nail plate spectral measurements and to provide a method for calibrating dose estimates from the radiation-induced signal measurements based on quantifying experiments in patients undergoing total-body irradiation or total-skin electron therapy.

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Q-band electron paramagnetic resonance dosimetry in tooth enamel: biopsy procedure and determination of dose detection limit

Cited by 27 publications

References 14 publications

Overview of physical dosimetry methods for triage application integrated in the new European network RENEB

Overview of physical dosimetry methods for triage application integrated in the new European network RENEB

Internal in vitro dosimetry for fish using hydroxyapatite-based EPR detectors

Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry

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