Q Fever Studies in Montana

Luoto, Lauri; Casey, Mary L.; Pickens, Edgar G.

doi:10.1093/oxfordjournals.aje.a120522

Cited by 22 publications

(2 citation statements)

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“…burnetii infection with that of controls. However, a relatively high positivity rate, approximately 10%, for C. burnetii infection among healthy controls suggests asymptomatic infection or healthy carrier status in adults, as reported in the USA [18]. Few human beings live in complete isolation from animals.…”

Section: Discussionmentioning

confidence: 95%

Detection ofCoxiella burnetiispecific DNA in blood samples from Japanese patients with chronic nonspecific symptoms by nested polymerase chain reaction

Kato

Arashima

Asai

et al. 1998

FEMS Immunology &Amp; Medical Microbiology

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The nested polymerase chain reaction (PCR) was used for direct species-specific detection of Coxiella burnetii in blood samples from 52 patients with chronic nonspecific symptoms, but no diagnostic or treatment history of Q fever. All patients had been in ill-health with general fatigue, muscle and joint pain, headache, etc., for one to more than 10 years. Seventeen (33%) showed evidence of C. burnetii infection, based on amplification of 438-bp fragments specific to C. burnetii by nested PCR, and 94% of positive patients reported close contact with animals. In contrast, five (9.6%) of 52 samples from healthy adult controls and two (2.8%) of 70 cord blood samples were positive by nested PCR. These data suggest a high prevalence of infection among adult patients with long term, nonspecific complaints who live in close contact with animals and the possible existence of a chronic post-acute Q fever syndrome in Japan.

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