Q-Switched Alexandrite Laser Treatment of Oral Labial Lentigines in Chinese Subjects with Peutz-Jeghers Syndrome

Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280 000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome. Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients. Intraoperative enteroscopy (IOE) was the only possibility for endoscopic treatment of patients with PJS before the DBE era. Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the patient. Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution, but also regular lifelong cancer screening (colonoscopy, upper endoscopy, computed tomography, magnetic resonance imaging or ultrasound of the pancreas, chest X-ray, mammography and pelvic examination with ultrasound in women, and testicular examination in men). Although the incidence of PJS is low, it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients, and to perform presymptomatic testing in the first-degree relatives of PJS patients.

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“…Q-switched lasers are the preferred method. The treatment is effective [98] , but this is only complementary cosmetic therapy.…”

Section: Screeningmentioning

confidence: 99%

Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach

Kopáčová

Tachecí²,

Rejchrt³

et al. 2009

WJG

195

183

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“…Effective laser therapy for the treatment of lip hyperpigmentation has been performed in the past with both normal‐pulsed and Q‐switched ruby laser, and Q‐switched alexandrite at both 752 nm and 755 nm wavelength . Additionally, Q‐switched Nd:YAG at both the 1064 nm and 532 nm wavelengths has been successfully used .…”

Section: Discussionmentioning

confidence: 99%

Q‐switched double‐frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation

Alharbi

2019

J of Cosmetic Dermatology

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Summary Introduction Lip darkening is a relatively common condition, especially in the Middle East and Southeast Asia. It is well documented in the literature and generally considered to be multifactorial. The presentation can be physiologic or pathologic and caused by a variety of local or systemic factors. Case presentation A 32‐year‐old female with skin type IV presented to the clinic with concerns of darkening lips with no associated symptoms or history of disease. On examination, her lips were homogenously dark brown with the upper lip slightly darker than the lower lip.ObjectiveTo report effectivness of Q‐switched 532 nm laser for treatment of lip pigmentation.MethodTopical 2.5% lidocaine/prilocaine (EMLA) cream was applied 30 minutes prior to laser therapy. The region was treated with Q‐switched 532 nm laser (Medlite).ResultTwo weeks after laser treatment , threre was satisfying subjective and objective improvment in lip pigmnetation.ConclusionQ‐Switched 532 nm laser effectively reduces lip pigmentation after one session with minimal adverse effects and lasting results.

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“…Usually, one or two treatments are needed to clear with no recurrences after one to two years of followup. [17][18][19][20] Treatment is well tolerated, with 40 Textbook of Laser and Light Dermatology in the Asian Skin erythema and edema occurring immediately after laser irradiation and crusting after two days, sloughing off within a week. 20 Although lesions may recur, they can be retreated without loss of efficacy.…”

Section: Casementioning

confidence: 98%

“…[17][18][19][20] Treatment is well tolerated, with 40 Textbook of Laser and Light Dermatology in the Asian Skin erythema and edema occurring immediately after laser irradiation and crusting after two days, sloughing off within a week. 20 Although lesions may recur, they can be retreated without loss of efficacy. 19 The risk of postinflammatory hyperpigmentation (PIH) after the use of the Q-switched lasers for the treatment of ephelides and lentigines ranges from about 17% 15 to 28% 13 in ethnic skin.…”

Section: Casementioning

confidence: 98%