Q‐switched Nd:<scp>YAG</scp>laser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study

Amin, Aliaa A.; Ragaie, Maha H

doi:10.1111/jocd.15660

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The topical antifungals are rarely effective due to their limited penetration of the nail plate. 3,10 Recent researches have reported the antifungal effects of keratolytics including TCA 100%, suggesting its role as adjuvant treatment for onychomycosis. 6,7 The suggested mechanisms of TCA in treatment of onychomycosis are related to its ability to acidify the nail and subsequently blocks fungal spreading, thereby allowing the rapid regrowth of normal nail plate.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of topical trichloroacetic acid 100% either alone or combined with topical tioconazole 28% versus systemic itraconazole in the treatment of onychomycosis

Ibrahim,

Elgharabawy

et al. 2024

Mycoses

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BackgroundTreatment of onychomycosis is still challenging and warrants the development of new treatment strategies. Different trials were conducted to increase the penetration and efficacy of topical antifungals aiming at finding an alternative treatment especially when systemic antifungals are contraindicated.ObjectivesTo evaluate the efficacy of trichloroacetic acid (TCA) 100% either alone or combined with topical tioconazole 28% versus itraconazole pulse therapy in the treatment of onychomycosis.Patients/MethodsForty‐five patients with onychomycosis were divided into three groups: group (A) treated by topical TCA 100% for 12 sessions, group (B) treated by TCA 100% for 12 sessions combined with topical tioconazole 28% for 18 weeks and group (C) treated by itraconazole (400 mg/day for 1 week/month for 4 months).ResultsTCA 100% combined with topical tioconazole 28% showed the highest therapeutic response; however, the difference between the groups was statistically insignificant. Mycological cure (negative culture) was reported in 66.7% of group B versus 60% of group A and 40% of group C at the 20 week.ConclusionsTCA 100% is an effective and safe treatment option for onychomycosis especially when combined with antifungals. This modality is promising in the treatment of onychomycosis especially with the increased resistance to different antifungals.

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Section: Discussionmentioning

confidence: 99%

“…The treatment of onychomycosis is commonly associated with high recurrence rates and treatment failure. The topical antifungals are rarely effective due to their limited penetration of the nail plate 3,10 …”

Section: Discussionmentioning

confidence: 99%

Efficacy of topical trichloroacetic acid 100% either alone or combined with topical tioconazole 28% versus systemic itraconazole in the treatment of onychomycosis

Ibrahim,

Elgharabawy

et al. 2024

Mycoses

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Laser Treatment in Nail Disorders: A Comprehensive Review

Chandrashekar,

Madura,

Shenoy

et al. 2024

Indian Dermatology Online Journal

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Background: Laser therapy has emerged as an innovative approach for managing various nail conditions, offering precise targeting, minimal invasiveness, and favorable safety profiles. This review analyzes the literature on laser therapy for nail indications, encompassing onychomycosis, nail psoriasis, nail warts, ingrown toenails, onychodystrophy, nail pigmentation disorders, and nail tumors. Methods: PubMed and Google Scholar databases were searched to identify articles on laser therapy using specific key terms related to nail conditions (e.g., onychomycosis, nail psoriasis). Relevant articles were shortlisted based on laser treatment in nail disorders, its mechanisms of action, research outcomes, and clinical applications. Results: Nd:YAG or CO2 lasers showed efficacy in onychomycosis by targeting fungal cells. Studies suggest that laser treatments offer comparable results to traditional therapies, often enhancing outcomes when combined with topical agents such as calcipotriol/betamethasone in nail psoriasis. For nail warts, ingrown toenails, onychodystrophy, and nail pigmentation disorders, lasers provide alternative or adjunctive therapies, achieving positive outcomes lesion clearance and symptom improvement. Conclusion: This review underscores the transformative potential of laser therapy in nail disorder management, providing clinicians with innovative treatment alternatives. Nevertheless, further studies are needed to refine protocols, evaluate long-term outcomes and explore its application in specific conditions such as nail tumors.

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Q‐switched Nd:YAGlaser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study

Cited by 2 publications

References 19 publications

Efficacy of topical trichloroacetic acid 100% either alone or combined with topical tioconazole 28% versus systemic itraconazole in the treatment of onychomycosis

Efficacy of topical trichloroacetic acid 100% either alone or combined with topical tioconazole 28% versus systemic itraconazole in the treatment of onychomycosis

Laser Treatment in Nail Disorders: A Comprehensive Review

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