Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial

Abstract

Background and Objectives: To compare the efficacy and safety of intradermal injection of tranexamic acid (TXA) versus Q switched (QS) KTP (532 nm) in the treatment of facial ephelides. Study Design/Materials and Methods: A randomized comparative split-face study included a total of 30 female patients with bilateral facial ephelides. One cheek was treated by intra-dermal TXA injections and the other was treated by QS-KTP (532 nm). Patient assessment was performed by photography, pigmentation area, severity index and spectrophotometry at baseline, 1 week after treatment, and 2 months after treatment. Results: A significant difference was found between both sides regarding the percentage change of pigmentation area, severity score (PSI) and melanin index (MI) after treatment and during follow up, favoring laser (P = 0.001). PSI decreased after treatment by 66.5% and 15.4% (laser and TXA sides respectively), further decrease after followup was 69.4% with laser and 26.1% with TXA. MI improved by 3.7% after KTP laser to 7.7% after follow-up and by 2.4% after TXA injections to 6.5% after follow-up. Four patients developed post-inflammatory hyperpigmentation following QS-KTP. Conclusion: QS-KTP laser is superior to intradermal TXA injection in the treatment of facial ephelides. Lasers Surg. Med.

Skin hyperpigmentation index in melasma: A complementary method to classic scoring systems

“…The cost could be a further criterion. Compared to other computerized pigment measurements 3,[11][12][13] or spectrophotometry, 14 SHI is very simple, quick, and cost-effective as only a smartphone and a dermoscopy adapter is needed.…”

Nghiên Cứu Đặc Điểm Lâm Sàng, Một Số Yếu Tố Liên Quan Và Đánh Giá Kết Quả Điều Trị Tàn Nhang Bằng Laser Q-Switched Nd: Yag Kết Hợp Bôi Tri-White Serum Tại Bệnh Viện Trường Đại Học Y Dược Cần Thơ Năm 2021-2022

“…Trong nghiên cứu của chúng tôi ghi nhận được kết quả thời gian mắc tàn nhang trung bình là 6,06 ± 2,963 năm, trong đó nhóm có thời gian mắc trên 5 năm chiếm tỷ lệ cao nhất (48,6%), tiếp theo là thời gian từ 3-5 năm (41,4%), 1-< 3 năm chỉ có 10%. Kết quả của chúng tôi tương tự so với nghiên cứu của Sayed và cộng sự (2021), thời gian mắc bệnh trung bình là 5,9 ± 4,3 năm, với thời gian mắc thấp nhất là 1 năm và cao nhất kéo dài tới 21 năm [4].…”

Non-Invasive, Non-Aggressive Approach for Managing Visible Facial and Neck Lesions

“…Common side effects of laser treatment in general include purpura, minor bleeding, edema, and erythema, dyspigmentation, blistering, crusting, and scarring [2]. Patients with darker skin types are especially at risk of post-inflammatory hyperpigmentation (PIH), with a reported incidence of 10-47% [6]. In the current retrospective cohort study, we aimed to examine the effects and safety profile of 532 nm KTP laser on pigmented lesions on the face and neck.…”