QBD-Based Development and Evaluation of Enteric Coated Mucoadhesive Microcapsules of Amoxicillin Trihydrate as a Novel Chronotherapeutic Approach for Treatment of Bacterial Infections

Prasad, Shyam Narayan; Patel, H. S.; Gothoskar, A. V.

doi:10.22159/ijpps.2018v10i8.27699

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…GMS in the formulation could protect the binding between the microcapsules and mucus to exert stable mucoadhesive properties during the experiment. Therefore, 55% (w/w) microcapsules FVI remained in the mucus after 3 h of the experiment period [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Microencapsulation Using Chitosan–ethyl Cellulose–gms Mixture for Preservation of Mucoadhesive Properties and Controlled Release Kinetic

et al. 2022

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Objective: This research aimed to prepare curcumin microcapsules by the spray drying method and to evaluate their characteristics. Methods: The microcapsules were prepared by the spray drying method. The generated microcapsules were evaluated for organoleptic, morphology, particle size, the percentage of curcumin and water content. Furthermore, the release of curcumin from the microcapsules was tested in vitro and compared to uncoated curcumin powder. In addition, the mucoadhesive properties of uncoated curcumin powder and curcumin microcapsules were also evaluated. Results: The results showed that the microcapsules had spherical shape with particle size in the range of 100–1009 µm and water content of 9.34% (w/w) (FIII) and 8.09% (w/w) (FVI). The release of curcumin from its uncoated powder and the microcapsules FVI within 8 h were 8.87% and 26.32% (w/w), respectively. It was found that the mucoadhesive properties of microcapsules FVI were better than those of FIII and uncoated curcumin powder. Microcapsules FVI rendered the cumulative amount of curcumin remaining on the intestinal mucosa of 55% (w/w) within 3 h. Conclusion: Accordingly, curcumin microcapsules generated by spray drying could be further formulated into various solid dosage forms for a better therapeutic effect.

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Section: Discussionmentioning

confidence: 99%

Curcumin Microencapsulation Using Chitosan–ethyl Cellulose–gms Mixture for Preservation of Mucoadhesive Properties and Controlled Release Kinetic

et al. 2022

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“…Denticap A shows potent % swelling. However, the % swelling of the Denticaps containing the drug was more than the blank polymer denticaps, which might be due to the presence of water of crystallinity in Amoxycillin trihydra 37,38 .…”

Section: Fig 9: Sem Images Of Zm Denticap Before Drug Releasementioning

confidence: 91%

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2023

IJPSR

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Novel drug delivery approach by using natural polymers is a newer area of formulation development. The oral drug delivery in the buccal cavity to treat the dental infections has some limitations such as slow onset of actions and is also affected by the first pass metabolism. In order to overcome these challenges plant derived mucoadhesive gum from the fruit pulp of Ziziphus mauritiana L.(ZM) is used in the preparation of Denticap and evaluated in vitro for to analysis its sustained release action. Antibacterial drug Amoxycillin Trihydrate has been taken as the model drug. The denticap was formulated using Carbopol 934P, Z Mgum, Ethyl cellulose and ethanol by solvent evaporation technique. The physicochemical parameters such as swelling index, surface pH, tooth adhesion test etc were carried out. The swelling % ranges from 40-55%. The tooth adhesive strength and pH was 45g and 6.7 respectively. The cumulative drug release from the ZM denticap was found to be 67% at 30 hr. The drug release kinetic study shows that formulation follows diffusion mechanism. The antibacterial study against various oral infection pathogens like Lactobacillus acidophillus, Staphylococcus aureus, Porphyromonas Gingivalis and Streptococcus mutans showed that the ZM gum possess certain antibacterial activity. SEM study shows the surface morphology of the denticap. The stability study following ICH guidelines shows that the formulation is stable. The formulated Denticap using ZM gum is a newer approach for sustained delivery of drug for treatment of dental infections. INTRODUCTION:Plants have been used in the traditional system of medicine for several thousand years. The development of various excipients that can be used in formulation development is moving toward utilizing natural sources in the modern world 1, 2 . Presently, many polysaccharides are identified and isolated from various plant sources 3, 4 . They are used in various formulations such as tablets, emulsions, suspensions, microparticle nanoparticles etc. Thus, to fulfill the increasing industrial demands for plant polysaccharides, it is vital to explore newer sources 5 .

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“…33 At present, certain optimize in-vivo and ex-vivo techniques of mucoadhesive formulations have been developed by using quality by design approach which is cost effective and even more convenient than other techniques. 34-37…”

Section: Methods Of Evaluation and Optimalcharacterisationof Mmddsmentioning

confidence: 99%

Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents

et al. 2019

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Innovations in pharmaceutical research are striving for designing newer drug therapies to eradicate deadly diseases. Strategies for such inventions always flourish with keys and objectives of minimal adverse effects and effective treatment. Recent trends in pharmaceutical technology specify that mucoadhesive drug delivery system is particularly appropriate than oral control release, for getting local systematic delivery of drugs in GIT for an extended interval of time at a predetermined rate. However, it is somehow expensive and unpleasant sensation for some patients, but still it is needful for getting short enzymatic activity, simple administration without pain and evasion of fast pass metabolism. Usually the vehicles employed in drug delivery of mucoadhesive system have a significant impact that draws further attention to potential benefits like improved bioavailability of therapeutic agents, extensive drug residence time at the site of administration and a comparatively faster drug uptake into the systemic circulation. The drug release from mucoadhesive multiparticulates is contingent on several types of factors comprising carrier need to produce the multiparticles and quantity of medication drug contained in them. Mucoadhesion is characterized by selected theories and mechanisms. Various strategies emergent in mucoadhesive multiparticulate drug delivery system (MMDDS) by in-vitro as well as ex-vivo description and characterization are also critically discussed. Apart from these, the primary focus during this review is to highlight current patents, clinical status, and regulatory policy for enhancement of mucoadhesive multi-particulate drug delivery system in the present scenario.

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QBD-Based Development and Evaluation of Enteric Coated Mucoadhesive Microcapsules of Amoxicillin Trihydrate as a Novel Chronotherapeutic Approach for Treatment of Bacterial Infections

Cited by 4 publications

References 14 publications

Curcumin Microencapsulation Using Chitosan–ethyl Cellulose–gms Mixture for Preservation of Mucoadhesive Properties and Controlled Release Kinetic

Curcumin Microencapsulation Using Chitosan–ethyl Cellulose–gms Mixture for Preservation of Mucoadhesive Properties and Controlled Release Kinetic

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Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents

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