QbD-based fabrication of transferrin-anchored nanocarriers for targeted drug delivery to macrophages and colon cells for mucosal inflammation healing

Abstract

Ulcerative colitis (UC) is a type of colon mucosal inflammation that attracts a plethora of immune cells. Colon drug targeting can be aided by exploiting overexpressed cell surface receptors which...

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

“…In the DSS-induced UC mouse model experiment, it demonstrated promising colon inflammation site-targeting potential based on tissue histopathological score, vascular integrity, and antioxidant levels. 132 Therefore, targeting TfR through drug delivery systems may be a promising active targeting therapy for IBD.…”

Dual pH and microbial-sensitive galactosylated polymeric nanocargoes for multi-level targeting to combat ulcerative colitis

“…In the search for better therapy, the second generation of ligand bound nanocarriers have been developed that target with greater binding affinity to the specific intestinal immune cell or colon cell membrane receptor ( e.g. , CD71, CD301b/macrophage galactose type C-type lectin 2 (MGL2), folate, transferrin, or mannose receptors) [18] , [19] , [20] , [21] . However, it is not clear that ligand-anchored nanocarriers can survive the harsh conditions of the GIT and reach the colon without any dose dumping.…”

QbD‐Based Fabrication of Biomimetic Hydroxyapatite Embedded Gelatin Nanoparticles for Localized Drug Delivery against Deteriorated Arthritic Joint Architecture

“…Similarly, we had already prepared QbD‐based d ‐galactose conjugated PLGA (Poly‐Lactic‐co‐Glycolic Acid) nanoparticles [ 26 ] and transferrin‐anchored PLGA nanocarriers. [ 27 ] Here, for the first time, n HA‐GLT NPs had been prepared using the QbD approach. The fabricated n HA‐GLT NPs had all the features of a nanosized carrier for Tofa, including targeted drug delivery, ease of penetration across the skin, sustained drug release, and improved localized effect.…”