QCM Based on Flow System for Cardiovascular Disease

Abstract

Abstract-Quartz Crystal Microbalance (QCM) is a special sensor which has acoustic impedance detector by mass loading. In this study Cardiac Troponin T (CTnT) which elevates in all patients with AMI diagnosed by World Heath Organization (WHO) criteria is used as immunoligical assay onto sensor. Detection of the Troponin T is developed based on antigenantibody system on QCM sensor as solid support and signal transduction for immobilization to monitor risk marker of myocardial infarction. To immobilize antibody, the sensor is functionalized with Polyvinyl chloride (PVC) doped COOH by spray coating technique. The modified sensor testing results can be given in short response time and a direct conversion of mass accumulation into a frequency shift representing a measurable electrical signal. The relationship between the Cardiac Troponin T concentration and the response current could be observed in the minimum concentration range at 5 ng/ml.

Sensitive immunosensing of α-synuclein protein in human plasma samples using gold nanoparticles conjugated with graphene: an innovative immuno-platform towards early stage identification of Parkinson's disease using point of care (POC) analysis

“… 33 The laboratory diagnosis of biomarkers associated with various diseases is one of the main areas for the development of various types of sensors including electrochemical, 34 optical, 35 and quartz crystal microbalance sensors. 36 Various bioreceptors including proteins, small molecules, and nucleic acids are efficacious bioreceptors for increasing the selectivity and sensitivity of sensors. Among the different types of bioreceptors, antibodies represent an important type of detection marker for several reasons.…”

Biosensing Platforms for Cardiac Biomarker Detection

“…This modification improved the sensitivity of the QCM biosensor compared with an uncoated surface. They observed that the frequency shift was directly proportional to the troponin T concentration, and the biosensor achieved an LOD of 5 ng/mL . This study demonstrates the potential of QCM biosensors in the sensitive detection of troponin T, a key cardiac biomarker used in diagnosing heart-related conditions.…”

A framework for remote monitoring of early heart attack diagnosis system for ambulatory patient

“…This can then be detected using magneto-resistive sensor to measure the amount of target analyte in the sample. Acoustic biosensor is based on mass of captured analyte on a surface of the sensor [9][10]. The surface of the sensor is coated with immobilized agent to the target analyte.…”