Quantum computers are currently regarded as an emerging computing technology that can solve problems more quickly than classical computers. However, since constructing a general quantum computer is technically difficult, quantum computer simulation has been used instead of real quantum computers. Simulating quantum computers on classical computers is challenging because the time and resources required for the vector–matrix multiplication (VMM) increase exponentially with the number of qubits. This paper proposes a new accelerator architecture called ReQUSA that leverages resistive random access memory (ReRAM) to accelerate the quantum computer simulation. The ReQUSA employs a ReRAM crossbar array structure, which is specialized for implementing the VMM, and a realized state method for reduced VMM operation. To the best of our knowledge, ReRAM-based accelerators for quantum computer simulator has not been previously reported. Here we describe the hardware design of the architecture and compare the performances (hardware resource, simulation time, and accuracy) of our accelerator with those of current quantum computer simulators (QuEST, QPlayer, and Qiskit). On average, our proposed architecture reduced the simulation times by factors of ×10^4 and ×10^3 (×10^2) on average from those of QuEST and QPlayer (also Qiskit), respectively. In addition, our architecture achieved 99% accuracy in 16-bit fixed-point data representation.