qSOFA score not predictive of in-hospital mortality in emergency patients with decompensated liver cirrhosis

Mûller, Martín; Schefold, Joerg C.; Leichtle, Alexander Benedikt; Srivastava, David; Lindner, Gregor; Exadaktylos, Aristomenis K.; Pfortmueller, Carmen A.

doi:10.1007/s00063-018-0477-z

Cited by 9 publications

(7 citation statements)

References 50 publications

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“…ASB, asymptomatic bacteriuria; ICU, intensive care unit; UTI, urinary tract infection in specific populations, such as patients with haematological malignancies 27 or cirrhosis. 28,29 In our study, qSOFA was the only score associated with inhospital mortality by multivariate analysis. It is quite striking that a simple score such as qSOFA were the only prognostic score that had an association with in-hospital mortality, while APACHE II and SOFA, more complex scores designed to measure the severity of disease or track the rate of organ failure for patients admitted to intensive care units, did not show any association.…”

Section: Discussionmentioning

confidence: 46%

Prognostic accuracy of Quick SOFA in older adults hospitalised with community acquired urinary tract infection

et al. 2021

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Section: Discussionmentioning

confidence: 46%

Prognostic accuracy of Quick SOFA in older adults hospitalised with community acquired urinary tract infection

et al. 2021

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“…Currently, the diagnosis of sepsis with the SOFA score to evaluate organ dysfunction in the setting of infection and the use of qSOFA to predict the severity and outcome of sepsis have been recommended by the Sepsis-3 consensus document. Müller et al[ 59 ] showed that qSOFA did not predict in-hospital mortality, intensive unit admission, or length of hospitalization in patients with decompensated cirrhosis. The application of sodium level to qSOFA (called qSOFA-Na + ) improved the diagnostic ability for identifying sepsis and mortality.…”

Section: Update On Prognostic Scoring Systems For Sepsis In Cirrhosismentioning

confidence: 99%

Update on diagnosis and management of sepsis in cirrhosis: Current advances

Philips¹,

Ahamed²,

Rajesh³

et al. 2020

WJH

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Sepsis and septic shock are catastrophic disease entities that portend high mortality in patients with cirrhosis. In cirrhosis, hemodynamic perturbations, immune dysregulation, and persistent systemic inflammation with altered gut microbiota in the background of portal hypertension enhance the risk of infections and resistance to antimicrobials. Patients with cirrhosis develop recurrent life-threatening infections that progress to multiple organ failure. The definition, pathophysiology, and treatment options for sepsis have been ever evolving. In this exhaustive review, we discuss novel advances in the understanding of sepsis, describe current and future biomarkers and scoring systems for sepsis, and delineate newer modalities and adjuvant therapies for the treatment of sepsis from existing literature to extrapolate the same concerning the management of sepsis in cirrhosis. We also provide insights into the role of gut microbiota in initiation and progression of sepsis and finally, propose a treatment algorithm for management of sepsis in patients with cirrhosis.

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“…However, more verification was not yet made in the related subgroups of the emergency department patients having high mortality. Müller M et al detected that the qSOFA did not predict in-hospital mortality, intensive care unit or hospitalization period in the patients with decompensated liver cirrhosis in the study performed on 186 patients with liver cirrhosis [25]. In our study, it was detected that positive result of one of the qSOFA criteria increased the specificity by 86.00% in predicting the poor prognosis in the AP.…”

Section: Discussionmentioning

confidence: 40%

Use of qSOFA criteria in prediction of poor prognosis in acute pancreatitis

Göktekin¹

2019

Ann Clin Anal Med

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Aim: In this study,we aimed to investigate the usability of SOFA and qSOFA criteria in predicting the conditions by which the poor prognosis such as hospitalization in the intensive care unit, long length of hospital stay and death was observed for the patients receiving a diagnosis of acute pancreatitis in the emergency department. Material and Method: The data of 98 patients with acute pancreatitis diagnosis which was verified by the computerized abdominal tomography in the university hospital emergency department between 2013 and 2018 were used in our study. that was designed as monocenteric retrospective study. The SOFA and qSOFA criteria of the patients were calculated during the application to the emergency department. Results: Fifty-three percent (n=52) of the patients were female. Their age averages were 57.5±18.57/year. Forty-eight (%49.0) patients were detected to have any of the poor prognostic criteria. It was also detected that the qSOFA score of 17 (517.3) patients were 1 and above and the qSOFA score of 81 (582.7) patients was 0 during the application to the emergency department. The SOFA (p<0.001) and qSOFA (p=0.004) values were significantly different for the patients having the good prognosis and poor prognosis. When we take the Cutoff as > 0 for the qSOFA criteria, we determined the AUC as 0.641, Sensitivity as %39.58, Specificity as %86, and CI% as 0.538 to 0.735, and p=0.001, respectively. Discussion: The SOFA and qSOFA criteria used in order to predict the organ failure in the sepsis can be a scoring system that will be able to be used in predicting the poor prognosis in acute pancreatitis in the emergency department.

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qSOFA score not predictive of in-hospital mortality in emergency patients with decompensated liver cirrhosis

Abstract: qSOFA does not predict in-hospital mortality, ICU admission or length of hospitalisation in patients with decompensated liver cirrhosis. Extension of qSOFA with a disease-specific component, the qSOFA-Na+, moderately increased the diagnostic ability of qSOFA.

Cited by 9 publications

References 50 publications

Prognostic accuracy of Quick SOFA in older adults hospitalised with community acquired urinary tract infection

Prognostic accuracy of Quick SOFA in older adults hospitalised with community acquired urinary tract infection

Update on diagnosis and management of sepsis in cirrhosis: Current advances

Use of qSOFA criteria in prediction of poor prognosis in acute pancreatitis

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