QT Dispersion in Patients with Polycystic Ovary Syndrome.

Abstract

SUMMARYCardiac risk factors are observed more frequently in patients with polycystic ovary syndrome (PCOS). On the other hand, increased QT dispersion, which is a risk factor for cardiac arrhythmias and sudden death, has not been investigated in this syndrome. In this study, we evaluated QT dispersion in PCOS patients without overt heart disease. Thirtysix consecutive women with PCOS (mean age 24±5 years) and 36 healthy women of similar ages (mean age 24±4 years) participated in this study. PCOS was diagnosed if there were polycystic ovaries by ultrasound (enlarged ovaries with ≥8 cysts 2-8 mm in diameter), oligoamenorrhea (intermenstrual interval >35 days), hirsutism (Ferriman-Gallwey score, ≥7) and elevated serum levels of testosterone (≥2.7 nmol/L). Electrocardiograms were recorded at a paper speed of 50 mm/s. QT intervals were manually measured by a cardiologist. All intervals were corrected for heart rate according to Bazett's formula: QTc interval=QT interval/square root of the RR interval. Mean values of body mass index, heart rate, and blood pressure were not significantly different between the two groups (P>0.05). No significant differences in QT intervals (maximum QT, minimum QT, QT dispersion, minimum corrected QT, maximum corrected QT, and corrected QT dispersion) were observed between the two groups (P>0.05). Our results suggest that the risk of ventricular arrhythmias or sudden cardiac death is not increased in PCOS patients. (Jpn Heart J 2002; 43: 487-493) Key words: Electrocardiography, Polycystic ovary syndrome, QT dispersion POLYCYSTIC ovary syndrome (PCOS) is a disorder of chronic anovulation, hyperandrogenism, hirsutism, obesity, subfertility, hyperlipidemia, and insulin resistance. Infertility is not the only important component of this syndrome, since the risks of cardiac disease and hypertension also increase in women with PCOS.1-3) Insulin resistance and hyperinsulinemia appear central to the pathophysiology of PCOS. Glucose intolerance, abnormally high fasting serum lipid concentrations, and high blood pressure are the three cardiac risk factors that have From the

Cardiac conductive disturbance in patients with polycystic ovary syndrome

“…Although the QT interval and QT dispersion were suggested to play a role in cardiac-related mortality, we found no differences in QT dispersion or QTc dispersion between patients with and without PCOS, which was similar to findings of previous studies [14,15]. In contrast, in this study, we found that the QRS duration was prolonged in the PCOS group.…”

“…Previous studies showed that PCOS patients had similar QT interval and QT dispersion compared to healthy women [14,15]. Interestingly, Orio et al [14] showed that PCOS has a tendency to prolong the QRS duration.…”

Relationship between QT dispersion with sex hormones and insulin in young women with polycystic ovary syndrome: an observational study

“…It has been reported that a negative correlation between serum testosterone level and QT duration, and shorter minimum QT durations in patients with PCOS (7). Accordingly, a study suggested that QT dispersion did not differ in patients and control subjects, however, relationship between sex hormone levels and QT durations was not reported in this study (8). It was known that change in hormonal values is related to menstrual cycle.…”

“…Alparslan et al (8) reported that QT dispersion did not differ between women with PCOS and controls. There was no information about the levels of estradiol in their study.…”

Assessment of atrial electromechanical interval and P wave dispersion in patients with polycystic ovary syndrome

“…Previous studies dealing with the QT dispersion and duration in patients with PCOS suggest that the risk of ventricular arrhythmias is not increased in these patients and these results were attributed to elevated testosterone levels (10, 11). On the other hand, PCOS was associated with ECG markers of the inhomogeneous atrial conduction, which has a predictive value for the atrial fibrillation (AF) (12).…”