QT dispersion predicts mortality and correlates with both coronary artery calcification and atherosclerosis in hemodialysis patients

Güney, Murat Can; Özkök, Abdullah; Çalışkan, Yaşar; Püşüroğlu, Hamdi; Yazıcı, Halil; Tepe, Savas; Oflaz, Hüseyin; Yildiz, Alaattin

doi:10.1007/s11255-013-0549-1

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…The link between LVH and prolonged QT found in HD patients in the present study has previously been demonstrated by a number of authors in patients with hypertension and hypertrophic cardiomyopathy 13 and also in HD patients. 21 , 23 , 24 However, the correlation between QTcd and LVH in HD patients is uncertain with some studies reporting positive correlation 14 , 21 , 24 and others, corroborating our findings, absence of correlation between these variables. 22 , 30 The current review of literature on the electric heterogeneity in LVH allows us to conclude that electrical disturbances do indicate ventricular structural abnormalities.…”

Section: Discussionsupporting

confidence: 86%

Reproducibility and Reliability Of QTc and QTcd Measurements and Their Relationships with Left Ventricular Hypertrophy in Hemodialysis Patients

Alonso

Lima

Carreira

et al. 2017

Arquivos Brasileiros De Cardiologia

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BackgroundLeft ventricular hypertrophy (LVH) is very common in hemodialysis patients and an independent risk factor for mortality in this population. The myocardial remodeling underlying the LVH can affect ventricular repolarization causing abnormalities in QT interval.Objectiveto evaluate the reproducibility and reliability of measurements of corrected QT interval (QTc) and its dispersion (QTcd) and correlate these parameters with LVH in hemodialysis patients.MethodsCase-control study involving hemodialysis patients and a control group. Clinical examination, blood sampling, transthoracic echocardiogram, and electrocardiogram were performed. Intra- and interobserver correlation and concordance tests were performed by Pearson´s correlation, Cohen’s Kappa coefficient and Bland Altman diagram. Linear regression was used to analyze association of QTc or QTcd with HVE.ResultsForty-one HD patients and 37 controls concluded the study. Hemodialysis patients tended to have higher values of QTc, QTcd and left ventricular mass index (LVMi) than controls but statistical significance was not found. Correlation and concordance tests depicted better results for QTc than for QTcd. In HD patients, a poor but significant correlation was found between QTc and LVMi (R2 = 0.12; p = 0.03). No correlation was found between values of QTcd and LVMi (R2= 0.00; p=0.940). For the control group, the correspondent values were R2= 0.00; p = 0.67 and R2= 0.00; p = 0.94, respectively.ConclusionWe found that QTc interval, in contrast to QTcd, is a reproducible and reliable measure and had a weak but positive correlation with LVMi in HD patients.

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Section: Discussionsupporting

confidence: 86%

Reproducibility and Reliability Of QTc and QTcd Measurements and Their Relationships with Left Ventricular Hypertrophy in Hemodialysis Patients

Alonso

Lima

Carreira

et al. 2017

Arquivos Brasileiros De Cardiologia

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“… 6 , 9 Recent literature suggests that various ECG changes, such as prolonged PR, QRS, or QTc intervals, may be independent risk predictors for cardiovascular (CV) death in patients with chronic kidney disease. 10 - 12 …”

Section: Introductionmentioning

confidence: 99%

TpTe and TpTe/QT: novel markers to predict sudden cardiac death in ESRD?

et al. 2019

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“…Further attempts to characterize this relationship have focused on QT dispersion, an electrocardiographic index that is generally higher in the dialysis population, and which correlates with risk for sudden cardiac death . At least three studies have found that QT dispersion significantly increases immediately after a dialysis session, when Mg fluxes would be expected to be greatest.…”

Section: Magnesium and Sudden Cardiac Deathmentioning

confidence: 99%

Clinical aspects of magnesium physiology in patients on dialysis

Misra

Nessim

2017

Seminars in Dialysis

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Magnesium balance is infrequently discussed in the dialysis population, and the clinical consequences of derangements in magnesium homeostasis are incompletely understood. There is an association between hypomagnesemia and adverse outcomes including increases in cardiovascular disease and mortality, while elevated magnesium levels have also been linked with complications such as osteomalacia. In this review, we discuss the features of magnesium physiology relevant to dialysis patients and provide an updated summary of the literature linking magnesium derangements with bone disease, cardiovascular disease, sudden cardiac death, and mortality.

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QT dispersion predicts mortality and correlates with both coronary artery calcification and atherosclerosis in hemodialysis patients

Abstract: QTcd independently predicted mortality, and it was significantly associated with coronary artery calcification, left ventricular hypertrophy and atherosclerosis in HD patients.

Cited by 10 publications

References 26 publications

Reproducibility and Reliability Of QTc and QTcd Measurements and Their Relationships with Left Ventricular Hypertrophy in Hemodialysis Patients

Reproducibility and Reliability Of QTc and QTcd Measurements and Their Relationships with Left Ventricular Hypertrophy in Hemodialysis Patients

TpTe and TpTe/QT: novel markers to predict sudden cardiac death in ESRD?

Clinical aspects of magnesium physiology in patients on dialysis

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