QT dispersion, QT maximum and risk of cardiac death in the Caerphilly Heart Study

Sheehan, John; Perry, Ivan J.; Reilly, Marie; Salim, Agus; Collins, Martina; Twomey, Eamonn; Daly, Aoife; Loingsigh, Sorcha Ni; Elwood, Peter Creighton; Ben‐Shlomo, Yoav; Smith, George Davey

doi:10.1097/01.hjr.0000114970.39211.9e

Cited by 25 publications

(16 citation statements)

References 29 publications

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“…QT dispersion, a marker of inhomogeneity of ventricular repolarization, has been reported to be a more sensitive and useful predictor of ventricular arrhythmias and sudden cardiac death than QT interval [7, 21]. An increase in QT dispersion has been shown in various disease states, such as coronary artery disease, cardiomyopathies and diabetes mellitus [9,10,11].…”

Section: Discussionmentioning

confidence: 99%

Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

et al. 2007

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Background: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. Methods: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 ± 8.0 years) steady-state SCD patients and 25 (mean age 19.6 ± 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett’s formula was used to obtain a rate-corrected value of the QT interval (QTc). Results: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCD patients compared to the control subjects (p < 0.0001, p < 0.05, p < 0.0001, respectively). Among SCD patients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p < 0.0001). However, minimum QTc showed no significant differences between the two patient groups. Conclusion: QTc dispersion is significantly increased in SCD patients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization.

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Section: Discussionmentioning

confidence: 99%

Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

et al. 2007

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“…QT interval prolongation has been implicated in the origin of ventricular arrhythmias, possibly because of less uniform recovery of ventricular excitability in the setting of regional differences in cardiac sympathetic nervous system activity. In addition, the increased inhomogeneity of ventricular repolarization, induced by LVH, can be indirectly detected by QT dispersion, a relatively simple measurement of 12-lead electrocardiogram (ECG) variability, and this index has been recently shown to be related to poor prognosis in large population studies (Okin 2000, Salles 2005, Elming 1998, Bruyne 1998, Sheehana 2004. Interestingly, heterogeneous ventricular repolarization was initially recognized in standard ECGs as early as 1934; however only recently QTc interval dispersion was identified as a marker of arrhythmia risk and sudden cardiac death in patients after myocardial infarction or with heart failure (Barr 1994, Glancy 1995, Anastasiou-Nana 2000.…”

Section: Qt-interval and Qt-dispersionmentioning

confidence: 99%

“…The direct linking mechanism between QT-dispersion, ventricular arrhythmias, LVH and adverse outcome has not been fully clarified yet. Increased QTc dispersion has been associated with increased regional heterogeneity of ventricular repolarization and it has been considered as a possible noninvasive surrogate marker of susceptibility to malignant ventricular arrhythmias and cardiovascular mortality in large population studies and, in cardiac patients (Okin 2000, Elming 1998, Bruyne 1998, Sheehana 2004, Barr 1994, Glancy 1995, Anastasiou 2000. The degree of myocardial interstitial fibrosis induced by either systemic arterial hypertension and/or by ageing, as well as the inhomogeneous myocyte hypertrophy caused mainly by arterial hypertension, might play an important role in increasing action potential duration and amplitude in different myocardial regions (Dimopoulos 2008(Dimopoulos ,2009.…”

Section: Qt-interval and Qt-dispersionmentioning

confidence: 99%

The Prognostic Role of ECG in Arterial Hypertension

Dimopoulos¹,

Manetos²,

Koroboki³

et al. 2012

Advances in Electrocardiograms - Clinical Applications

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“…The standard 12-lead electrocardiogram (ECG), which provides information about the QT interval, is a representation of depolarization and repolarization of the ventricular myocytes. Thus, it is assumed that the increased QTd observed in cardiac diseases with heterogeneous ventricular recovery times reflects the disparity of ventricular recovery times (8,9). The QTd is a simple, inexpensive and noninvasive method to measure underlying dispersion recovery of ventricular excitability.…”

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confidence: 99%

Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization

KaraveliogAAlu¹,

Karapınar²

2015

Curr Res Cardiol

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69Y Karavelioğlu, H Karapınar, M Kalçık, Z Küçükdurmaz, S Özkurt, T Sarak. Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization. Curr Res Cardiol 2015;2(2):69-72.BaCKgRound: The effects of varenicline, an effective drug for smoking cessation, on atrioventricular and ventricular conductance remain unknown. oBjeCTive: To evaluate the effects of varenicline on heart rate, PR interval, QT interval and QT dispersion (QTd). MeTHodS: A total of 60 smokers were prospectively enrolled in the present study. Twelve-lead electrocardiogram recordings were obtained for all subjects before and on the 15th day of drug administration. Electrocardiograms were recorded at an amplitude of 20 mm/mV and a sweep speed of 50 mm/s. ReSulTS:The mean (± SD) age of the volunteers was 38±10 years. Thirtyfour (57%) were male. Fourteen (23%) had hypertension, eight (13%) had diabetes and six (10%) had chronic obstructive pulmonary disease. The mean heart rate was 74.7±13.3 beats/min, and mean systolic and diastolic blood pressures on admission were 122.3±14.3 mmHg and 76.5±10.2 mmHg, respectively. Heart rate, and systolic and diastolic blood pressures did not change with varenicline treatment. Varenicline treatment resulted in limited prolongation in PR interval, which appropached significance (163.5±18.3 ms versus 168.2±17.9 ms; P=0.053), while RR interval (796.3±117.4 ms versus 798.3±123.7 ms; P=0.926), QT interval (384.1±17.5 ms versus 383.4±20.9 ms; P=0.852) and QTd (52.6±14.9 ms versus 52.2±14.9 ms; P=0.919) were not significantly changed. ConCluSion: Varenicline had a limited effect on atrioventricular conduction, while it had no effect on heart rate, QT interval and QTd. Further studies are needed to prove the effects of varenicline on the conduction system of the heart, especially on PR interval.

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QT dispersion, QT maximum and risk of cardiac death in the Caerphilly Heart Study

Cited by 25 publications

References 29 publications

Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

The Prognostic Role of ECG in Arterial Hypertension

Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization

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