QT interval in anorexia nervosa.

Cooke, Richard A.; Chambers, John; Singh, Rajvinder; Todd, George J.; Smeeton, Nigel; Treasure, Janet; Treasure, T

doi:10.1136/hrt.72.1.69

Cited by 127 publications

(108 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Major cardiovascular complications that could cause sudden death in AN patients are acute heart failure or ventricular arrhythmia due to hypokalemia or hypomagnesemia (5)(6)(7). The electrocardiographic (ECG) abnormalities associated with AN are sinus bradycardia, low voltage P waves and QRS complexes, QTc interval prolongation, non-specific ST-T changes, ST segment depression or U waves, most of which are reversible (5)(6)(7)(8)(9)(10)(11). ST-T change or T wave inversion are considered to result from stimulation of hypothalamic sympathetic centers causing release of catecholamines within the myocardium (12).…”

Section: Introductionmentioning

confidence: 99%

“…ST-T change or T wave inversion are considered to result from stimulation of hypothalamic sympathetic centers causing release of catecholamines within the myocardium (12). Echocardiographic abnormalities in this disease consist of mitral valve prolapse (MVP), diminished LV mass, pericardial effusion, and reduced stroke volume or cardiac output (5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ampulla Cardiomyopathy after Hypoglycemia in Three Young Female Patients with Anorexia Nervosa

et al. 2005

View full text Add to dashboard Cite

Ampulla cardiomyopathy is named after the echocardiographic abnormalities occurring in this condition, characterized by extensive akinesis (ballooning ) of the apical region with hypercontraction of the basal segment of the ventricle. We describe 3 young female anorexia nervosa patients showing evidence of this cardiac complication after hypoglycemia. One case was complicated by echocardiographically confirmed ampulla cardiomyopathy while the other 2 patients showed increases in myocardial enzymes and transient electrocardiographic abnormalities consistent with this complication. The precipitating event for all three patients was hypoglycemic coma, and this is the first case report in which this factor lead to the complication of ampulla cardiomyopathy in anorexia nervosa patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ampulla Cardiomyopathy after Hypoglycemia in Three Young Female Patients with Anorexia Nervosa

et al. 2005

View full text Add to dashboard Cite

show abstract

“…As well as defining the 'disease' state in eating disorders, nutritional status is highly correlated with mortality and morbidity, including osteoporosis (Treasure et al, 1986;Bachrach et al, 1990;Brooks et al, 1998;Hotta et al, 1998), infertility (Kohmura et al, 1986), and cardiac complications (Cooke et al, 1994;Swenne & Larsson, 1999). The boundary between health and disease in eating disorders in terms of body composition is crucial to recognition and treatment, but hard to define.…”

Section: Introductionmentioning

confidence: 99%

Body composition in early onset eating disorders

Nicholls¹,

Wells²,

Singhal³

et al. 2002

Eur J Clin Nutr

View full text Add to dashboard Cite

Background: Body mass index (BMI) or equivalent weight for height indices are the most widely used measures of body composition in early onset and adolescent eating disorders. Although of value as screening instruments the limitation in disease states is their inability to discriminate fat and fat-free components of body weight. Objective: To compare height-adjusted fat and fat-free components of body composition in children and young adolescents with different types of eating disorders with those of age matched reference children. Design: Weight, height, triceps and subscapular skinfold thickness were measured in 172 children (aged 7 -16 y) with eating disorders receiving specialist treatment. Fat mass index (FMI) and fat-free mass index (FFMI) were calculated using Slaughter's and Deurenberg's equations and normalisation for height. Using data from 157 normal children, representative of the UK 1990 growth reference data, reference curves for FMI and FFMI AE 2 s.d. were derived. Results for patient groups were superimposed on these reference curves.Results: FMI and FFMI were both reduced in eating disorders associated with malnutrition, including anorexia nervosa (AN). AN subjects did not differ from other subjects with comparable degrees of malnutrition. Children with eating disorders of normal weight, such as bulimia nervosa and selective eating, did not differ significantly from reference children in their relative FM and FFM. Conclusions: FM and FFM merit independent consideration in disorders of malnutrition in children, rather than expressing data as percentage body fat or percentage BMI. The implications of loss of FFM on growth and development merit further investigation.

show abstract

“…Patients with AN suffer from bone marrow suppression, liver failure and numerous metabolic complications as a result of severe malnutrition.1 Cardiac complications are fairly common occurring in up to 80% patients ranging from rhythm disturbances, low voltage EKG, QT prolongation, ST-T segment changes, U waves, hypotension, decreased cardiac output, cardiomyopathy and mitral valve prolapse. 2,3 Myocardial damage is thought to reversible with reasonably good prognosis upon regaining weight. 4 Various postulated mechanisms include reduced LV mass, hypoglycemia and stress induced catecholamine excess like cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

Nutritional therapy leads to complete recovery of left ventricular dysfunction in anorexia nervosa: A case report

Wats¹,

Batul²,

Plawes³

et al. 2016

ICFJ

View full text Add to dashboard Cite

A young female presented to our hospital with lethargy and dehydration with EKG changes notable for T wave inversions in precordial and inferior leads. Echocardiogram showed severely reduced left ventricular (LV) function. Patient was diagnosed with anorexia nervosa and started on high calorie diet as per metabolic recommendations, ace inhibitor, beta-blockers and statin. 10 month follow up showed a significant improvement in heart function showing the reversible nature of anorexia nervosa induced cardiac dysfunction Cardiac abnormalities, specifically cardiomyopathy are known in patients with Anorexia nervosa and have been attributed to the deficiency of multitude of minerals, vitamins and electrolytes. It is important to recognize that patients with anorexia can develop cardiac dysfunction and early nutrition along with medical optimization can lead to complete reversal of cardiac dysfunction. Multi-disciplinary team approach involving cardiologist, metabolic support, internist, and psychiatrist is required for appropriate care of these patients.

show abstract

QT interval in anorexia nervosa.

Cited by 127 publications

References 26 publications

Ampulla Cardiomyopathy after Hypoglycemia in Three Young Female Patients with Anorexia Nervosa

Ampulla Cardiomyopathy after Hypoglycemia in Three Young Female Patients with Anorexia Nervosa

Body composition in early onset eating disorders

Nutritional therapy leads to complete recovery of left ventricular dysfunction in anorexia nervosa: A case report

Contact Info

Product

Resources

About