QT interval measurement in the dog: Chest leads versus limb leads

Nahas, Kamil; Geffray, B.

doi:10.1016/j.vascn.2004.05.004

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…However, the better correlation between potassium level and QT recorded in CV5RL, compared with DII values, shows that the former lead gives more accurate results. This is consistent with the findings of a previous study and is explained by a better definition of the end of the T wave and, consequently, lower error in measuring the QT duration in CV5RL (Nahas & Geffray 2004).…”

Section: Discussionsupporting

confidence: 93%

Quantitative relationship between plasma potassium levels and QT interval in beagle dogs

Hanton

Yvon

et al. 2007

Lab Anim

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The aim of the current study was to establish the quantitative relationship between plasma potassium concentrations and the QT interval of the electrocardiogram in dogs. Furosemide, a potent diuretic, was given at increasing doses (5-60 mg/kg) to five male and five female beagle dogs. Electrocardiogram (ECG) was recorded three times each day, simultaneous to blood sampling for measurement of plasma potassium. Furosemide treatment produced a clear hypokalaemia, which was associated with an increase in QT and corrected QT intervals (QTc) duration. On average, the slopes of the negative linear correlation between potassium plasma levels and QT or QTc were steeper in females than in males. These results show that a decrease in potassium plasma level may explain a concomitant increase in QT duration in a toxicity study in dogs, in particular if potassium values are decreased below 3.3 mmol/L. Correction of QT interval for K+ plasma level has, therefore, been established separately for males and females. A global formula correcting QT for K+ and heart rate simultaneously was established. Hypokalaemia was also associated with changes in the morphology of the T wave recorded in CV5RL, in particular, with a flattening and/or a notching of the wave (appearance of a second peak), biphasic aspect or inversion of polarity. These changes are probably related to an increased heterogeneity of repolarization between different populations of cardiomyocytes. In conclusion, hypokalaemia is quantitatively associated with an increase in QT and QTc duration in dogs. The relationship is apparently stronger for females than for males. A formula may be used to correct QT for potassium plasma level.

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Section: Discussionsupporting

confidence: 93%

Quantitative relationship between plasma potassium levels and QT interval in beagle dogs

Hanton

Yvon

et al. 2007

Lab Anim

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“…Other reports recommend this measurement in leads II, V 2 and V 3 , because the T wave is always well defined and often reaches the maximal amplitude in these leads (Elming et al, 2003;Viskin et al, 2003;Vohra, 2003;Fenichel et al, 2004;Charbit et al, 2006). A similar situation has been determined in dogs, where the lead CV 5 RL seems to produce less intra-and inter-animal variability as it well defined at the end (Nahas and Geffray, 2004). Other authors claim that the QTi can be measured from the longest QT period in a strip if the lead is well defined or not (Fenichel et al, 2004).…”

Section: Measurement Of the Qt Intervalsupporting

confidence: 59%

Tomenendalova J: How to approach the QT interval in dogs - the state of the heart: a review

Agudelo¹,

Scheer²,

Tomenendálová³

2011

Vet. Med. - Czech

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ABSTRACT:The QT interval has been the objective of exhaustive attention in the past and also in recent times. A number of conditions, congenital and acquired, can have a direct effect on cardiac repolarization. Also drug regulatory agencies have showed increasing interest in the topic because certain drugs can prolong the QT interval to a level that produces ventricular arrhythmias. The dog is a species that shares some similarities with the human electrical system and has been used in human and veterinary research. We here present the current recommendations for QT measurement in dogs for use in clinical and experimental practice.

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“…During recording of ECG, goats were kept in a wooden box. Needle electrodes were inserted subcutaneously proximal to the olecranon on the caudal aspect of the right and left forelegs for the right and left arm wires, respectively, and in the external aspect of the stifle joint of the right and left leg wires, respectively [17]. The three standard bipolar limb leads (I, II, and III) and augmented unipolar limb leads (aVR, aVL and aVF) were recorded on paper using a threechannel physiograph (Medicare, Chandigarh).…”

Section: Electrocardiogram Recordingmentioning

confidence: 99%

Alterations in Electrocardiographic Parameters after Subacute Exposure of Fluoride and Ameliorative Action of Aluminium Sulphate in Goats

Kant

Srivastava

Verma

et al. 2009

Biol Trace Elem Res

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Fluorosis or crippling disease is one of the existing environmental challenges for animal and human beings in most parts of the globe. In the present study, sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the effect on the electrocardiogram. All waves of Lead I, Lead II, Lead III, aVR, aVL and aVF in electrocardiographs were recorded before and after 30 days exposure of fluoride. A significant (P < 0.05) increase in P-R, Q-T and S-T intervals were observed in goats of group 1 as compared to their pre treatment values. The T wave duration was also significantly (P < 0.05) prolonged and as a result, bradycardia was observed after subacute exposure of fluoride for 30 days in group 1. But, in group 2, no such changes were observed. On the basis of results, it may be concluded that subacute toxicity of fluoride produces significant changes in different waves of electrocardiogram and aluminium sulphate has ameliorative efficacy.

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QT interval measurement in the dog: Chest leads versus limb leads

Cited by 11 publications

References 3 publications

Quantitative relationship between plasma potassium levels and QT interval in beagle dogs

Quantitative relationship between plasma potassium levels and QT interval in beagle dogs

Tomenendalova J: How to approach the QT interval in dogs - the state of the heart: a review

Alterations in Electrocardiographic Parameters after Subacute Exposure of Fluoride and Ameliorative Action of Aluminium Sulphate in Goats

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