QTc prolongation and valproate toxicity

Kazim, Sara; Mohindra, Rohit; Gosselin, Sophie; Larocque, Alexandre

doi:10.3109/15563650.2013.775580

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…There was only one case of VT/VF associated with valproic acid overdose and no cases of TdP; previous case reports suggest that valproate may cause QTc prolongation, possibly due to hypocalcemia [59,60].…”

Section: Discussionmentioning

confidence: 91%

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Al-Abri

Woodburn

Olson

et al. 2015

Am J Cardiovasc Drugs

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Key PointsThe most commonly involved therapeutic classes of drugs associated with ventricular fibrillation and/or tachycardia (VT/VF) were antidepressants (25 %) and stimulants (25 %).The drugs most commonly associated with torsade de pointes (TdP) were antidepressants (25 %) and methadone (25 %).Drug exposures with the greatest risk of death in association with VT/VF were antidepressant exposure [odds ratio (OR) 1.71] and antiarrhythmic exposure (OR 1.75), but neither association was statistically significant.

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Section: Discussionmentioning

confidence: 91%

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Al-Abri

Woodburn

Olson

et al. 2015

Am J Cardiovasc Drugs

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show abstract

“…34 IGF-1 increases both the activity and the expression of hEAG channels through an AKT-dependent pathway, 195 and restoration of depressed hERG channel function is proposed as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits. 196 Although some HDAC inhibitors have also been reported to inhibit hERG channel through complex transcriptional changes of genes required for ion channel trafficking, 197 there is no evidence that VPA (discussed above) prolongs the QT interval [198][199][200] and therefore, by inference, does not inhibit the hERG channel.…”

Section: Potential Use In Oncologymentioning

confidence: 99%