QTL for meat tenderness in the M. longissimus lumborum of cattle

Davis, Geoff; Moore, S. S.; Drinkwater, R. D.; Shorthose, W. R.; Loxton, I.; Barendse, W.; Hetzel, David J.

doi:10.1111/j.1365-2052.2007.01677.x

Cited by 23 publications

(14 citation statements)

References 44 publications

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“…Meat tenderness is known to be affected by polymorphisms in the calpain and calpastatin genes, and these polymorphisms differ in allele frequency between Brahman and Bt cattle (White et al, 2005;Barendse et al, 2007Barendse et al, , 2008Davis et al, 2008). However, none of calpain and calpastatin genes was detected within the highly significant LDPF segments.…”

mentioning

confidence: 88%

Detection of chromosome segments of zebu and taurine origin and their effect on beef production and growth1

Bolormaa¹,

Hayes²,

Hawken³

et al. 2011

Journal of Animal Science

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Cattle in breeds formed by recent crossing of Bos taurus (Bt) and Bos indicus (Bi) subspecies should contain chromosomes that are a composite of Bt and Bt segments. Using data from a 50K SNP chip, we were able to identify whether a chromosome segment of 11 SNP in a composite animal descended from a Bt or a Bi ancestor. When the method was tested in purebred Bt or Brahman cattle, about 94% of segments were assigned correctly. About 10% of the genome in Australian Brahman cattle appears to be of Bt origin, as might be expected from their history. We then examined the effect of the origin of each chromosome segment on BW in a population of 515 Bt × Bi composite cattle and found 67 chromosome segments with a significant (P < 0.01) effect. We confirmed these effects by examining these 67 segments in a population of Brahman cattle and in a population of mixed breeds including composite breeds such as Santa Gertrudis and Brahman cattle. About 66% of the 67 segments had an effect in the same direction in the confirmation analyses as in the discovery population. However, the effect on BW and other traits of chromosome segment origin is small, indicating that we had low power to detect these effects with the number of animals available. Consequently, when chromosome segment origin was used in genomic selection to predict BW, the accuracy was low (0.08). Chromosome segments that had a positive effect on BW tend to be at greater frequency in composite breeds than chromosome segments with a negative effect on BW.

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mentioning

confidence: 88%

Detection of chromosome segments of zebu and taurine origin and their effect on beef production and growth1

Bolormaa¹,

Hayes²,

Hawken³

et al. 2011

Journal of Animal Science

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“…Several bovine quantitative trait loci (QTL) for meat tenderness have been identified [1][2][3][4][5][6][7][8][9]. Ten different genomic regions on chromosomes 4, 5, 7, 8, 9, 10, 15, 20, 25 and 29 have been, so far, associated with meat tenderness in cattle.…”

Section: Introductionmentioning

confidence: 99%

Genetic Variability and Linkage Disequilibrium Patterns in the Bovine DNAJA1 Gene

et al. 2009

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Correlation between expression level of the bovine DNAJA1 gene and meat tenderness was recently found in Charolais longissimus thoracis muscle samples, suggesting that this gene could play an important role in meat tenderness. Here, we report the validation of polymorphisms within the bovine DNAJA1 gene, and the haplotype variability and extent of linkage disequilibrium in the three main French beef breeds (Blonde d'Aquitaine, Charolais, Limousin). Genotyping 18 putative SNPs revealed that 16 SNPs were polymorphic within the breeds tested. Two SNPs were removed from further analyses as one SNP had a low genotyping call rate, while the other SNP was not in Hardy-Weinberg equilibrium. The degree of heterozygosity observed for the remaining 14 SNPs varied between breeds, with Charolais being the breed with the highest genetic variation and Blonde d'Aquitaine the lowest. Linkage disequilibrium and haplotype structure of DNAJA1 were different between breeds. Eighteen different haplotypes, including three shared by all breeds, were discovered, and two to three tag SNPs (depending on the breed) are sufficient to capture all the genetic variability seen in these haplotypes. The results of this study will facilitate the design of optimal future association studies evaluating the role of the DNAJA1 gene in meat tenderness.

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“…There are some other studies that have reported QTL for tenderness in cattle (Alexander et al, 2007;Casas et al, 2000Casas et al, , 2001Casas et al, , 2003Davis et al, 2007;Drinkwater et. al., 2006;Esmailizadeh et al, 2011;Gutiérrez-Gil et al, 2008;Keele et al, 1999).…”

Section: Quantitative Trait Loci For Tendernessmentioning

confidence: 99%

“…Quantitative trait loci or regions of the genome that affect tenderness have been identified in a variety of studies (Alexander et al, 2007;Casas et al, 2000Casas et al, , 2001Casas et al, , 2003Davis et al, 2007;Drinkwater et al, 2006;Esmailizadeh et al, 2011;Gutiérrez-Gil et al, 2008). In some cases, the gene variants that underlie these QTL have been discovered and include the µ-calpain (CAPN1) on BTA 29 and the calpastatin (CAST) genes (Casas et al, 2006), and earlier reports from the project herein include the myostatin (MSTN) gene variant F94L on BTA 2 (Morris et al, 2006;Esmailizadeh et al, 2008;Lines et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…In some cases, the gene variants that underlie these QTL have been discovered and include the µ-calpain (CAPN1) on BTA 29 and the calpastatin (CAST) genes (Casas et al, 2006), and earlier reports from the project herein include the myostatin (MSTN) gene variant F94L on BTA 2 (Morris et al, 2006;Esmailizadeh et al, 2008;Lines et al, 2009). To date, studies on tenderness QTL and DNA variants have analyzed shear force data at different aging days individually in a univariate analysis (Alexander et al, 2007;Aslan et al, 2010;Chung and Davis, 2012;Davis et al, 2007;Esmailizadeh et al, 2008;Fan et al, 2011;Lines, 2006;Ujan et al, 2011a,b;Zhou et al, 2010). In this project, an analysis of shear force across days or adjusted shear force was conducted with the aim of having a more precise measure, which would provide a better understanding of the genetics underlying tenderness and aid the mapping of QTL for tenderness.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling tenderness for genetic and quantitative trait loci analyses1

Chang

Pitchford

Bottema

2014

Journal of Animal Science

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Tenderness is the one of the most important attributes of beef with regards to the intent of consumers to repurchase. Beef tenderness is frequently measured objectively as Warner-Bratzler shear force. However, to better understand the genetics underlying tenderness, better descriptors were derived herein. Two traits, adjusted shear force and aging rate, were calculated to incorporate measures of Warner-Bratzler shear force repeated over aging time of 2 muscles, longissimus dorsi (LD) and semitendinosus (ST). Analysis of these traits indicated that the shear forces of the 2 muscles are lowly correlated and aging rate, as calculated, was not correlated with adjusted shear force. Breed, SNP, and QTL effects were analyzed for the 4 traits (2 traits × 2 muscles). For adjusted shear force, the QTL were located on cattle chromosomes BTA 5, 18, 25, and 29. With the exception of the QTL on BTA 5, the adjusted shear force QTL were observed for either the LD or the ST but not both muscles. The QTL for aging rate were located on BTA 1, 4, 7, 11, 13, 19, and 20.

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QTL for meat tenderness in the M. longissimus lumborum of cattle

Cited by 23 publications

References 44 publications

Detection of chromosome segments of zebu and taurine origin and their effect on beef production and growth1

Detection of chromosome segments of zebu and taurine origin and their effect on beef production and growth1

Genetic Variability and Linkage Disequilibrium Patterns in the Bovine DNAJA1 Gene

Modeling tenderness for genetic and quantitative trait loci analyses1

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