Suppose Q is a definite quadratic form on a vector space V over some totally real field K = Q. Then the maximal integral ZK -lattices in (V, Q) are locally isometric everywhere and hence form a single genus. We enumerate all orthogonal spaces (V, Q) of dimension at least 3, where the corresponding genus of maximal integral lattices consists of a single isometry class. It turns out, there are 471 such genera. Moreover, the dimension of V and the degree of K are bounded by 6 and 5 respectively. This classification also yields all maximal quaternion orders of type number one.