Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

Maruyama, Nobuyuki; Okubo, Yuko; Umikawa, Masato; Matsuzaki, Akiko; Hokama, Akira; Hirano, Fusahiro; Maruyama, Tessho; Nishihara, Kazuhide; Nakasone, Toshiyuki; Makishi, Shoko; Nakamura, Hiroyuki; Yoshimi, Naoki

doi:10.3390/diagnostics10040218

Cited by 3 publications

(1 citation statement)

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“…Nevertheless, it must be kept in mind that endoscopic procedures may be important in some KS patients in order to exclude second primary malignancies 25 …”

Section: Discussionmentioning

confidence: 99%

Mucosal Kaposi's sarcoma in HIV‐negative patients: a large case series from a single, tertiary referral center in Italy

et al. 2021

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Background Mucosal involvement in HIV‐negative Kaposi's sarcoma (KS) is uncommon but has potentially serious repercussions on patient care. Evidence regarding its epidemiology and optimal management is limited. Invasive endoscopic staging at diagnosis and periodically during follow‐up is currently recommended by major guidelines. Materials and methods We reviewed the clinical records of 1,308 HIV‐negative KS patients followed at our dedicated KS outpatient service. Demographics, clinical characteristics, and treatment outcomes for cases with biopsy proven mucosal lesions were collected. Results Mucosal involvement was documented in 53 patients (4.1% of our cohort), being present at diagnosis in 28 (52.8%) and occurring at a later time in the remaining 25 (47.2%) patients, with a mean latency of 8 years (±7.7). Oral cavity (43.4%) and glans penis (39.6%) were the most frequently involved anatomical sites. Of those with available treatment response data, complete response (CR) of mucosal KS was appreciated in 41 cases (93.2%), while partial response (PR) and stable disease (SD) were documented in one (2.3%) and two cases (4.5%), respectively. Same‐site recurrences were noticed in seven patients (17.1%). Conclusion Mucosal involvement in HIV‐negative KS is rare, and its recurrence, if properly treated, appears to be infrequent. Thus, routine invasive monitoring in this setting may be unnecessary. We propose a tailored approach based on the clinical manifestations of each patient, limiting the indication of invasive procedures to the first evaluation and in case of significant clinical worsening or to monitor known mucosal localizations.

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“…Nevertheless, it must be kept in mind that endoscopic procedures may be important in some KS patients in order to exclude second primary malignancies 25 …”

Section: Discussionmentioning

confidence: 99%

Mucosal Kaposi's sarcoma in HIV‐negative patients: a large case series from a single, tertiary referral center in Italy

et al. 2021

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Case report: Quadruple primary malignant neoplasms including esophageal, ureteral, and lung in an elderly male

et al. 2022

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Multiple primary malignant neoplasms (MPMNs) are defined as multiple tumors with different pathogenic origins. MPMNs are rare, but the morbidity rate is on the rise. With the development of anti-tumor treatments, such as targeted therapy and immunotherapy, the overall survival of cancer patients has been significantly prolonged, leading to an increased number of patients with MPMNs. A crucial aspect of MPMNs management is deciding how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. Herein we report a 60-year-old male who developed four different malignancies, including esophageal squamous cell carcinoma, upper urinary tract urothelial carcinoma, mediastinal small cell lung cancer, and left lung squamous cell carcinoma over 20 years and received appropriate treatment of each cancer with long survival.

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Investigation of CDH1 germline mutations in Turkish patients with Kaposi’s sarcoma

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Tunçer

2022

Turkish Journal of Biochemistry

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Objectives Kaposi’s sarcoma (KS) develops from the lining cells of blood or lymphatic vessels and may appear as red, purple, brown, or black lesions. E-cadherin, CDH1, is a cell adhesion molecule located on the surface of epithelial cells. CDH1 gene expression is downregulated in several cancers and is considered a tumor suppressor gene involved in epithelial-mesenchymal transition in carcinomas. Loss of CDH1 gene expression is observed in many carcinomas, mainly diffuse gastric carcinomas and lobular breast carcinomas, as well as skin tumors. This study investigates the CDH1 germline mutations in HIV-negative (Human Immunodeficiency) Virus KS patients in the Turkish population. Methods The study examined 25 peripheral blood mononuclear cells from KS patients using the Sanger sequencing technique. Results Sixteen exons of the CDH1 gene were sequenced, and a pathogenic functional germline mutation, HET c.2245C > T, p.(Arg749Trp) rs776975632, NM _004360.5, was identified in a patient with a family history of gastric and breast cancer with a high number of lesions compared to other KS patients. Discussion: KS patients with a family history of cancer could be screened for CDH1 gene and cancer-related-gen variants in the future. Conclusions KS is a rare malignancy, and genetic analysis will benefit KS patients. Further studies are needed to describe better the variations detected in a large number of KS patients in this study.

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Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

Cited by 3 publications

References 50 publications

Mucosal Kaposi's sarcoma in HIV‐negative patients: a large case series from a single, tertiary referral center in Italy

Mucosal Kaposi's sarcoma in HIV‐negative patients: a large case series from a single, tertiary referral center in Italy

Case report: Quadruple primary malignant neoplasms including esophageal, ureteral, and lung in an elderly male

Investigation of CDH1 germline mutations in Turkish patients with Kaposi’s sarcoma

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