Quadruple primary urogenital cancers – A case report

Elec, Florin Ioan; Zaharie, Andreea; Ene, Bogdan-Mihai; Ghervan, Liviu

doi:10.1016/j.ijscr.2017.08.035

Cited by 4 publications

(1 citation statement)

References 13 publications

(13 reference statements)

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“…Solid tumors comprised 90% of all second malignancies in RCC patients, with the most common second cancers reported in the prostate gland and the digestive and respiratory systems. As shown in Table 1 , in recent years, only five synchronous primary PRAD cases have been reported in RCC patients, with an average age of 68 [ 8 , 9 , 10 , 11 , 12 ]. Most cases (three cases) were diagnosed as RCC of Furhman grade II and PRAD of Gleason score more than 6.…”

Section: ⧉ Discussionmentioning

confidence: 99%

Primary prostate cancer synchronous with renal cell carcinoma: clinical experience and literature review

Ying

Wan

et al. 2020

Rom J Morphol Embryol

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The objective of this study was to report the diagnosis and treatment results of primary prostate adenocarcinoma (PRAD) concurrent in a patient with renal cell carcinoma (RCC), and to review the relative literature. A 62-year-old man was admitted to our hospital with chief complaint of a painless, incidentally found renal mass for one year. RCC was initially found by computed tomography (CT) scan, but prostate cancer was incidentally found by abnormal prostate-specific antigen (PSA) level results. The post-nephrectomy pathology assay reported clear RCC with positive staining of vimentin, cluster of differentiation 10 (CD10), carbonic anhydrase IX (CA-IX), paired box 8 (Pax-8), epithelial membrane antigen (EMA), and Ki67 labeling index (Ki67 LI). Magnetic resonance imaging (MRI) revealed uneven signals in the right peripheral zone of the prostate. Both prostate biopsy and post-prostatectomy pathology examination revealed prostate acinar adenocarcinoma with positive staining of P504S and Ki67 LI. The patient has been in periodic follow-up and has remained in good general condition without any evidence of recurrence to date. To the best of our knowledge, the present report is the only case of systematically described pre-and post-therapy laboratory, pathology, and imaging examination results. Our report together with published studies suggest that increased awareness of synchronous PRAD risk will enable early detection and prompt therapies in patients with RCC.

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Section: ⧉ Discussionmentioning

confidence: 99%

Primary prostate cancer synchronous with renal cell carcinoma: clinical experience and literature review

Ying

Wan

et al. 2020

Rom J Morphol Embryol

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Erratum to “Erratum to “The SCARE guidelines: Consensus-based surgical case report guidelines” [Int. J. Surg. 34 (2016) 180–186]” [Int. J. Surg. 36 (2016) 396]

Agha

Fowler

Saeta

et al. 2017

International Journal of Surgery

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Multiple primary tumors: a case report and review of the literature

Zhao

Sun

Yan

et al. 2020

BMC Musculoskelet Disord

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Background Multiple primary tumors, especially quadruple primary neoplasms is extremely rare. Fibrous dysplasia (FD), osteosarcoma (OS), and giant cell tumor of bone (GCTB) are three bone tumors with low incidence while primary pulmonary meningioma is a rare disease. In this case report, we present a unique synchronous occurrence of these four separate pathological conditions. Case presentation A 53-year-old male previously underwent resection of OS of fifth rib and FD of eighth rib 1 year ago. Recently, a discontinuous pain at right knee developed. Serial X-ray films showed a progressively pure osteolytic lesion of proximal tibia which extended gradually. The incisional biopsy revealed that this tumor was confirmed as GCTB, and the tumor was successfully managed by extensive curettage and bone cement filling. The diagnosis of GCTB was re-confirmed by the postoperative histopathologic examinations. High-throughput sequencing from the GCTB exhibited a somatic mutation of H3.3A (G35W exon2). Germline testing revealed a germ-cell variant in gene of BRCA2 (exon 8 V220Ifs*4). Conclusions This is a unique case with quadruple primary tumors. Germline mutation in gene of BRCA2 may be associated with the occurrence of multiple primary tumors in this patient.

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Quadruple primary urogenital cancers – A case report

Cited by 4 publications

References 13 publications

Primary prostate cancer synchronous with renal cell carcinoma: clinical experience and literature review

Primary prostate cancer synchronous with renal cell carcinoma: clinical experience and literature review

Erratum to “Erratum to “The SCARE guidelines: Consensus-based surgical case report guidelines” [Int. J. Surg. 34 (2016) 180–186]” [Int. J. Surg. 36 (2016) 396]

Multiple primary tumors: a case report and review of the literature

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