Polluted sediments limit the useful and biotic life of a water reservoir. Therefore, the classification and verification of the contamination and pollution levels of water reservoirs are essentials for the preservation of the biota and to organize the actions of environmental management. Thus, the aim of this study is to determine the concentrations of potentially toxic metals [lead (Pb), zinc (Zn), nickel (Ni), copper (Cu), and cadmium (Cd)] in sediment samples collected in the water reservoir of the Foz do Rio Claro Hydroelectric Power Plant (FRCHEPP) and estimate the contamination level by using the geoaccumulation index (Igeo). All results were compared with the values established by the CONAMA Resolution 454/2012. The Cu and Cd concentrations in the sediment samples were above Level II for most of the analyzed points in comparison with the data of the CONAMA resolution, being classified as poor quality sediments. Moreover, the Igeo values indicated potential pollution of the water reservoir sediment by Cu and Cd. Hence, the water reservoir was classified between moderately and extremely polluted. From this work it is possible to conclude that the frequent monitoring of the sediment quality in the FRCHEPP water reservoir is an indispensable action for periodic evaluation of the hydrographic basin quality in the study region, considering its importance as water supply and power generation for the state of Goiás, Brazil. Overall, the results of this work can be important to study other water reservoirs around the world.