Qualify of life and palliation predict survival in patients with chronic alveolar hypoventilation and nocturnal ventilatory support

Olofson, Jan; Dellborg, Catharina; Sullivan, Marianne; Midgren, Bengt; Caro, Oscar; Bergman, Bengt

doi:10.1007/s11136-009-9445-7

Cited by 10 publications

(17 citation statements)

References 28 publications

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“…Of the 76 full-text articles, 38 (representing quantitative HRQOL evaluations among 28 unique cohorts of TB patients) were relevant to our review [ 1 – 4 , 6 , 9 , 10 , 12 – 21 , 26 , 29 , 31 – 33 , 35 , 37 , 38 , 39 , 40 , 45 , 46 , 49 , 51 – 53 , 56 , 57 , 59 , 60 ]. Studies included in the systematic review were published in English, Korean, Chinese, Spanish, and Turkish.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-seven of the 28 unique cohorts reported the number of women, which corresponded to 42 % of the subjects in these studies [ 1 – 4 , 6 , 9 , 10 , 12 – 15 , 18 – 21 , 26 , 29 , 31 – 33 , 35 , 37 , 38 , 39 , 40 , 45 , 46 , 49 , 51 – 53 , 56 , 57 , 59 , 60 ]. Mean age (reported in 13 studies) was the most frequently reported summary measure of age [ 1 – 4 , 6 , 13 – 15 , 20 , 21 , 26 , 32 , 33 , 38 , 45 , 46 , 52 , 53 , 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 4 of the 28 unique studies evaluated HRQOL among subjects with patients with post-TB sequelae who developed chronic alveolar hypoventilation (CAH) and were using home mechanical ventilation (HMV); see “Appendix 4 ” and Table 7 in Appendix [ 9 , 10 , 19 , 37 , 39 , 56 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life

2012

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PurposeTo summarize the impact of tuberculosis (TB) on quantitative measures on self-reported health-related quality of life (HRQOL).MethodsWe searched eight databases to retrieve all peer-reviewed publications reporting original HRQOL data for persons with TB. All retrieved abstracts were considered for full-text review if HRQOL was quantitatively assessed among subjects with TB. Full-text articles were reviewed by two independent reviewers using a standardized abstraction form to collect data on socio-demographic characteristics, questionnaire administration, and mean HRQOL scores. Meta-analyses were performed for standardized mean differences in HRQOL scores, comparing subjects treated for active TB with subjects treated for latent TB infection (LTBI), or with healthy controls, at similar time points with respect to diagnosis and/or treatment.ResultsFrom over 15,000 abstracts retrieved, 76 full-text articles were reviewed, which represented 28 unique cohorts (6,028 subjects) reporting HRQOL among subjects with active TB; 42 % were women and mean age was 42 years. Data on key social and behavioral determinants were limited. Within individual studies and in meta-analyses, subjects with active TB disease consistently reported worse HRQOL than concurrently evaluated subjects treated for LTBI. However, meaningful improvements in HRQOL throughout active TB treatment were reported by longitudinal studies.ConclusionsIn a variety of studies, in different settings and using different instruments, subjects with active TB consistently reported poorer HRQOL than persons treated for LTBI. Future research on HRQOL and TB should better address social and behavioral health determinants which may also affect HRQOL.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life

2012

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“…151 Patients may know little or nothing about this modality of therapy and education by referring providers and pulmonary rehabilitation personnel concerning the possible benefits of its use in hospital, at home, or in training can help avoid misunderstandings, facilitate more informed decisions, ease fears, and offer hope of palliation of symptoms to them and their families. 152,153 In patients with chronic respiratory diseases and refractory dyspnea or pain, opioid therapy may be beneficial and is recommended in the recent guideline on palliative care by the American Thoracic Society. 8 Oral, nebulized, and systemic opioids have been evaluated in controlled trials in patients with cancer and COPD.…”

Section: The Palliative Outcomes Of Pulmonary Rehabilitationmentioning

confidence: 99%

Pulmonary Rehabilitation and Palliative Care

McCormick¹

2009

Semin Respir Crit Care Med

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Pulmonary rehabilitation has been demonstrated to improve symptoms and quality of life of patients with chronic respiratory diseases. These benefits are not necessarily associated with physiological improvement and have not been shown to improve mortality. In this sense, its goals are palliative. Rehabilitation programs assess patients' knowledge of their diseases, degree of symptoms such as dyspnea and fatigue, understanding of common therapies, and capacity for exercise. The exercise component of pulmonary rehabilitation improves function within the rehabilitation setting and may translate to increased activity at home for some patients. The programs also offer additional opportunities to identify for referring providers potentially undetected underlying comorbidities such as sleep disturbances, anxiety, and depression, which contribute to a poor quality of life for many patients. In addition, patients and their caregivers can be encouraged to ask questions about interventions during exacerbations, the meaning of advance care planning, and goals for end of life care with the intent that these dialogues will lead to further discussions with their doctors and families.

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“…HRQL is known to predict mortality in cancer patients[6–8] and in a range of other diseases and clinical settings including HIV[9], respiratory conditions[10], cardiac surgery[11], and intensive care[12], possessing predictive power beyond that of demographic and clinical measures alone. General health and physical functioning were the most often cited domains.…”

Section: Introductionmentioning

confidence: 99%

Joint models for predicting transplant-related mortality from quality of life data

2013

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Purpose To test whether longitudinally measured health-related quality of life (HRQL) predicts transplant-related mortality (TRM) in pediatric hematopoietic stem cell transplant (HSCT). Methods The predictors of interest were emotional functioning, physical functioning, role functioning, and global HRQL, as rated by the parent about the child up to 6 times over 12 months of follow-up and measured by the Child-Health Ratings Inventories (CHRIs). We used joint models, specifically shared parameter models, with time to TRM as the outcome of interest and other causes of mortality as a competing risk, via the JM software package in R. Choosing shared parameter models instead of standard survival models, such as Cox models with time-dependent covariates, enabled us to address measurement error in the HRQL trajectories and appropriately handle missing data. The non-linear trajectories for each HRQL domain were modeled by random spline functions. The survival submodels were adjusted for baseline patient, family, and transplant characteristics. Results Hazard ratios per one-half standard deviation difference in emotional, physical, and role functioning and global HRQL were 0.61 (95% CI: 0.46 to 0.81; p<0.001), 0.70 (0.51 to 0.96; p=0.03), 0.54 (0.34 to 0.85; p=0.007), and 0.57 (0.41 to 0.79; p<0.001), respectively. Conclusions HRQL trajectories were predictive of TRM in pediatric HSCT, even after adjusting the survival outcome for baseline characteristics.

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Qualify of life and palliation predict survival in patients with chronic alveolar hypoventilation and nocturnal ventilatory support

Abstract: Seventy-three percent of patients treated for CAH with NPPV survived more than 5 years. Diagnosis and self-rated physical functioning at pre-treatment were related to survival, as were major improvements in physical functioning and global QL during NPPV.

Cited by 10 publications

References 28 publications

A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life

A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life

Pulmonary Rehabilitation and Palliative Care

Joint models for predicting transplant-related mortality from quality of life data

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