Qualitative analysis of the acetogenins from <i>Annona coriacea</i> (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens

Terezan, Ana Paula; Junqueira, João Gabriel M.; Wakui, Vinícius Galvão; Kato, Lucília; Oliveira, Cecília Maria Alves de; Martins, Carlos Henrique Gomes; Santiago, Mariana Brentini; Severino, Vanessa Gisele Pasqualotto

doi:10.1080/14786419.2020.1803312

Cited by 8 publications

(4 citation statements)

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“…Acetogenins compounds (1a-c, 2a-c, 3a-b isomers) were identified in the four samples (Table 1); 5a-c isomers [9] are present in three samples (AcL1, AcL3, and AcL4). Regarding the relative areas of the compounds identified (Figure 4), the main constituents of the most active fraction (AcL3) are 1a, 2c, 3a, and 5b isomers (80.10%).…”

Section: Acetogenins Are Present In All Fractionsmentioning

confidence: 99%

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Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

et al. 2023

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Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising source for elucidating new anti-glioblastoma compounds. Accordingly, this study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart., enriched with acetogenins, against GBM cell lines. All four fractions were selectively cytotoxic to GBM cells when compared to TMZ. Moreover, A. coriacea fractions delayed cell migration; reduced cytoplasmic projections, the metalloproteinase 2 (MMP-2) activity; and induced morphological changes characteristic of necroptosis, possibly correlated with the increase in receptor-interacting protein kinase 1 and 3 (RIP-1 and RIP-3), apoptosis-inducing factor (AIF), and the non-activation of cleaved caspase 8. The present findings reinforce that fractions of A. coriacea Mart. should be considered for more studies focusing treatment of GBM.

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Section: Acetogenins Are Present In All Fractionsmentioning

confidence: 99%

“…The ethyl acetate fraction (20.4 g) was chromatographed on a silica gel (70-230 mesh) column (5.0 × 13.0 cm) with hexane/ethyl acetate/methanol gradient (1:0:0; 1:1:0; 0:1:0; 0:1:1; 0:0:1) to yield five fractions (6)(7)(8)(9)(10). Fr.…”

Section: Plant Materials and Extractionmentioning

confidence: 99%

Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

et al. 2023

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“…The chemical diversity present in Annonaceae species is vast, yielding a plethora of natural compounds such as alkenes [4], terpenoids [5], alkaloids [6][7][8][9][10], and phenols [11]. These compounds demonstrate a broad spectrum of pharmacological activities, including anti-mosquito [12], anti-cancer [13][14][15], antibacterial [16], anti-protozoal [17,18], and antifungal [19]. Among them, Annonaceous acetogenins stand out for their potent anti-tumor potential, making them one of the most promising natural product discoveries [20].…”

Section: Introductionmentioning

confidence: 99%

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

Sun,

Xin,

et al. 2024

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Artabotrys, a pivotal genus within the Annonaceae family, is renowned for its extensive biological significance and medicinal potential. The genus’s sesquiterpene compounds have attracted considerable interest from the scientific community due to their structural complexity and diverse biological activities. These compounds exhibit a range of biological activities, including antimalarial, antibacterial, anti-inflammatory analgesic, and anti-tumor properties, positioning them as promising candidates for medical applications. This review aims to summarize the current knowledge on the variety, species, and structural characteristics of sesquiterpene compounds isolated from Artabotrys plants. Furthermore, it delves into their pharmacological activities and underlying mechanisms, offering a comprehensive foundation for future research.

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“…Um estudo fitoquímico de suas folhas mostrou, por meio de HPLC, uma mistura complexa de acetogeninas anonáceas, com a identificação pela primeira vez de silvaticina e gigantetrocina-A. Além disso, o extrato bruto da folha e as frações ricas em acetogenina foram testados contra cepas de Streptococcus mutans, S. mitis, S. sanguinis e S. salivarius (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i7.16736 revelando potencial para agente antimicrobiano (Terezan et al, 2020). Outras propriedades biológicas são relatadas na literatura, como atividade antifúngica dos extratos etanólicos da casca e folhas frente Cryptococcus gattii e C. neoformans (Almeida-Apolonio et al, 2019), atividade anticolinesterásica para os extratos metanólicos das folhas e sementes (Formagio et al 2015;Fernandes & Scapin, 2020).…”

Section: Introductionunclassified

Óleo fixo de Annona coriacea Mart. (Annonaceae) e suas atividades anticolinesterásica, antimicrobiana e antifúngica

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et al. 2021

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Este estudo avaliou as atividades anticolinesterásica, antimicrobiana e fungicida do óleo fixo das sementes de araticum (Annona coriacea Mart., família Annonaceae), obtido com etanol como solvente extrator. O óleo fixo foi testado in vitro contra a enzima acetilcolina, cepas bacterianas gram-positivas (Staphylococcus aureus e S. epidermides) e gram-negativas (Escherichia coli e Pseudomonas aeruginosa), e fungos (Candida albicans, C. krusei, Neoscytalidium dimidiatum e Fusarium sacchari). O óleo fixo mostrou-se inibidor da enzima acetilcolinesterase, com inibição variando de 37 a 84%. Foi inativo contra bactérias gram-positivas, gram-negativas e fungos, com MIC ≥1024, através do ensaio antimicrobiano. Permitiu controles de crescimento micelial de N. dimidiatum nas cinco doses testadas (0.1, 0.5, 1.0, 2.0 e 3.0 µL mL-1). Não foi observado controle significativo contra F. sacchari, as doses 1, 2 e 3 (0.1, 0.5 e 1.0 µL mL-1) apresentaram porcentagens baixas de inibição, enquanto as doses 4 e 5 apresentaram controle, entretanto, o mesmo não diferiu do crescimento micelial no tratamento controle com meio de cultura. Pode-se concluir que o óleo fixo das sementes de araticum é um forte candidato ao desenvolvimento de fitofármacos à base de A. coriacea contra fungos patogênicos.

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Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens

Cited by 8 publications

References 22 publications

Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

Óleo fixo de Annona coriacea Mart. (Annonaceae) e suas atividades anticolinesterásica, antimicrobiana e antifúngica

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