Qualitative and quantitative salivary changes and subjective oral dryness among patients with thyroid dysfunction

Naik, Meghal Mehul; Vassandacoumara, Vaishnavee

doi:10.4103/ijdr.ijdr_501_16

Cited by 7 publications

(12 citation statements)

References 1 publication

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“…These proportions are slightly lower in our case group as compared to the study done by Muralidharan et al [17] The mean pH values of both the cases and controls were in the normal range. This is in agreement with the study done by Muralidharan et al and Naik et al [17,19] The mean buffering capacity of saliva among the controls was higher than that of cases. The low buffering capacity of saliva is associated with a reduced salivary flow and particularly increased risk for caries.…”

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivasupporting

confidence: 93%

“…The low buffering capacity of saliva is associated with a reduced salivary flow and particularly increased risk for caries. These findings were in accordance with the study done by Muralidharan et al and Naik et al [17,19] The questionnaire obtained from the study carried out by Farsi in 2007 was used to determine the perception of subjective oral dryness among the subjects. [12] The present study results suggest that oral dryness was more among the thyroid disorder patients than the healthy controls.…”

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivasupporting

confidence: 89%

“…These findings are in agreement with the recent literature. [19][20][21] The mean USFR in the case group was within the normal range quoted in literature while that of the control group was slightly higher than normal. During the time of collection of saliva, slight movement of the tongue and cheeks alter the true unstimulated saliva, thereby signifying attention when we interpret the USFR results.…”

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivasupporting

confidence: 75%

“…During the time of collection of saliva, slight movement of the tongue and cheeks alter the true unstimulated saliva, thereby signifying attention when we interpret the USFR results. [19,22] The mean SSFR in the case and the control groups were within the normal limits for normal population. These proportions are slightly lower in our case group as compared to the study done by Muralidharan et al [17] The mean pH values of both the cases and controls were in the normal range.…”

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivamentioning

confidence: 53%

“…[18] A study done by Naik et al in 2018 stated the unstimulated and stimulated salivary flow rates in hyperthyroid and hypothyroid patients. [19] In our study, we have determined unstimulated salivary flow rate (USFR) and stimulated salivary flow rate (SSFR) in thyroid disorders patients. The present study suggests that a thyroid disorders are more commonly seen in females than males.…”

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivamentioning

confidence: 99%

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Qualitative and Quantitative Analysis of Changes in Saliva and Subjective Oral Dryness in Patients with Thyroid Disorders

Hassan¹,

Nadaf²,

Gupta³

2019

AJMR

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Background:The association of salivary function with numerous systemic illnesses has been stated by various researches. There is a strong relationship of salivary function with common illnesses like diabetes, oral submucous fibrosis, and asthma. Thyroid dysfunction are one of the most common endocrine disorders worldwide. Aims and objective: To determine the qualitative and quantitative changes in the salivary function in patients with thyroid dysfunction. Subjects and Methods: A cross-sectional study was carried out on 40 subjects, including 20 thyroid disorders patients and 20 control subjects. Unstimulated and stimulated salivary flow rates, pH, and buffering capacity of the whole saliva were determined as well as subjective oral dryness in the study subjects. Results: In the present study, a statistically significant decrease in salivary parameters such as buffering capacity and flow rates was seen. Subjective oral dryness was observed in affected patients. Conclusion:In the present study, a correlation between thyroid dysfunction and salivary gland function was observed in patients with thyroid disorders.

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Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivasupporting

confidence: 93%

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivasupporting

confidence: 89%

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivasupporting

confidence: 75%

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivamentioning

confidence: 53%

Section: Hassan Et Al; Qualitative and Quantitative Analysis Of Changes In Salivamentioning

confidence: 99%

See 3 more Smart Citations

Qualitative and Quantitative Analysis of Changes in Saliva and Subjective Oral Dryness in Patients with Thyroid Disorders

Hassan¹,

Nadaf²,

Gupta³

2019

AJMR

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Impact of photobiomodulation therapy on the morphological aspects of submandibular gland submitted to excretory duct ligation and hypothyroidism: an animal study

et al. 2021

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The aim of this study was to evaluate the impact of photobiomodulation therapy (PBMT) on histomorphological aspects of submandibular gland (SMG) submitted to salivary gland duct obstruction in hypothyroid rats. Fifty-six male Wistar rats (250 to 300 g) were divided into 4 groups (n = 14): euthyroid (EU), EU + PBMT, hypothyroid (HYPO), and HYPO + PBMT. Duct obstruction of the left submandibular gland (LSMG) was performed in all animals by a ligature procedure. For the induction of hypothyroidism, total thyroidectomy was performed. PBMT groups received irradiation with AlGaInP diode laser (808 nm, 0.04 W, 0.04cm 2 spot size, 60 s, 2.4 J per point, 60 J/cm 2 , 1 W/cm 2 ). Irradiation was performed immediately, 24 h, and 48 h after the obstruction of the salivary gland duct, in one point, extra oral and perpendicular to the gland. Animals were sacrificed after 24 h and 72 h after duct ligature. Our results indicated that salivary duct obstruction and hypothyroidism caused negative modifications on the salivary glands' histomorphology, especially acinar atrophy, after 24 h and 72 h. HYPO + PBMT showed a significant reduction of the inflammatory infiltrate, congested blood vessels, and acinar atrophy in the SMG submandibular salivary gland in 72 h compared to 24 h (p < 0.05). In conclusion, obstruction of the salivary gland excretory duct and hypothyroidism causes severe sialoadenitis with expressive atrophy of the glandular parenchyma. However, PBMT was able to modulate the inflammatory process and delaying acinar atrophy. This study provided insights to better understand the role of the PBMT on the altered salivary gland by duct ligation and associate hypothyroidism.

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Unstimulated whole salivary flow in Sjögren’s Syndrome: systematic literature review and meta-analysis

et al. 2021

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Background Sjögren’s Syndrome compromises the exocrine function, producing xerostomia and xerophthalmia. It can appear as an isolated condition or associated with other autoimmune diseases (polyautoimmunity). The Unstimulated Salivary Flow rate (UWSF) is used to quantify saliva production. There is no objective evidence to differentiate the values in patients with Sjögren’s versus healthy people or patients with non-Sjögren’s sicca. The objective of the present review was to evaluate the UWSF in patients with Sjögren’s syndrome in comparison to controls (healthy and non-Sjögren’s sicca patients). Methods A systematic literature review was carried out (PRISMA guidelines). Analytical observational studies of cases and controls, cross-sectional studies, cohort studies and randomized clinical trials (including healthy controls) were considered. The Medline/OVID, Lilacs, Embase, and Cochrane/OVID databases were consulted. MeSH, DeCS, keywords, and Boolean operators were used. The meta-analysis (RevMan 5.2) was done through the random-effects model [mean difference (MD)]. Level and quality of evidence were evaluated by the Oxford Center Levels of Evidence and Joanna Brigs list respectively. Results Thirty-two articles were included (20 were case-control studies, 6 were cross-sectional, 2 prospective cohort, 2 retrospective cohort, and 2 studies were abstracts) and 28 were meta-analyzed. The unstimulated whole salivary flow rate in the Sjögren’s group was lower than in controls (healthy and patients with non-Sjögren Sicca syndrome) (MD-0.18 ml/min; 95% CI, − 0.24 to − 0.13; chi2-P-value < 0.00001). Heterogeneity was 97% and there was publication bias (funnel plot). The level of evidence was mostly 3 or 4. The quality of evidence was met (97% of items valued). Conclusion For the first time, the unstimulated whole salivary flow rate is found to be lower in patients with Sjögren’s syndrome compared to controls (healthy and non-SS sicca) through a meta-analysis. Trial registration PROSPERO CRD42020211325.

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Qualitative and quantitative salivary changes and subjective oral dryness among patients with thyroid dysfunction

Abstract: The study was able to establish an association between thyroid dysfunction and salivary gland function. We hope that this study leads to more high-impact research in this field as salivary diagnostics is gaining more popularity with every passing day.

Cited by 7 publications

References 1 publication

Qualitative and Quantitative Analysis of Changes in Saliva and Subjective Oral Dryness in Patients with Thyroid Disorders

Qualitative and Quantitative Analysis of Changes in Saliva and Subjective Oral Dryness in Patients with Thyroid Disorders

Impact of photobiomodulation therapy on the morphological aspects of submandibular gland submitted to excretory duct ligation and hypothyroidism: an animal study

Unstimulated whole salivary flow in Sjögren’s Syndrome: systematic literature review and meta-analysis

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