Qualitative and Quantitative Tests for Stannous Fluoride

Hefferren, John J.

doi:10.1002/jps.2600521115

Cited by 23 publications

(5 citation statements)

References 17 publications

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“…It has been reported that H 2 O 2 can induce the oxidation of SnF 2 as H 2 O 2 is a well-known oxidizing agent 41 – 43 . To assess the stability of SnF 2 when mixed with Fer after the catalytic reaction, we conducted a series of experiments.…”

Section: Resultsmentioning

confidence: 99%

Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

Huang,

Liu,

Pandey

et al. 2023

Nat Commun

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Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF2), markedly inhibiting both biofilm accumulation and enamel damage more effectively than either alone. Unexpectedly, we discover that the stability of SnF2 is enhanced when mixed with Fer in aqueous solutions while increasing catalytic activity of Fer without any additives. Notably, Fer in combination with SnF2 is exceptionally effective in controlling dental caries in vivo, even at four times lower concentrations, without adverse effects on host tissues or oral microbiome. Our results reveal a potent therapeutic synergism using approved agents while providing facile SnF2 stabilization, to prevent a widespread oral disease with reduced fluoride exposure.

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Section: Resultsmentioning

confidence: 99%

Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

Huang,

Liu,

Pandey

et al. 2023

Nat Commun

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“…At lower pH, more calcium-fluoride-like precipitates are formed [Scholz et al, 2019], which have a slight anti-erosive potential [Huysmans et al, 2014]. However, adjusting the F/Sn solution was not possible because the stannous ions are hardly stable in their divalent form at a neutral pH [Hefferren, 1963]. Lowering the pH of the other groups would potentially have led to more erosive tissue loss in the groups without F and F/Sn.…”

Section: Discussionmentioning

confidence: 99%

Interaction between Hexametaphosphate, Other Active Ingredients of Toothpastes, and Erosion-Abrasion in Enamel in vitro

Luka,

Duerrschnabel,

Neumaier

et al. 2023

Caries Res

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Sodium hexametaphosphate (HMP) as toothpaste additive is claimed to reduce erosive tooth wear and to stabilize stannous ions. However, little is known about the impact of concentration and its interactions with fluoride (F) or stannous+fluoride ions (F/Sn) on enamel erosion and erosion-abrasion. In a ten day cyclic in-vitro erosion-abrasion model, 320 flat human enamel specimens were divided into ten groups (n = 32 each) and daily subjected to six erosive challenges (0.5% citric acid, 2 min) and two toothpaste suspension applications (2 min, 1:3 F-free toothpaste:mineral-salt-solution, 0.23% sodium-gluconate). Half of specimens per group were additionally brushed twice/day (200 g, 15 s) during suspension immersion. Nine suspensions contained HMP (0.25%, 1.75%, 3.25%), either on its own or combined with F (373 ppm F-) or F/Sn (800 ppm Sn2+, 373 ppm F-). One suspension contained sodium-gluconate only (NegContr). After ten days, specimens’ surfaces were analyzed with profilometry, energy dispersive x-ray spectroscopy and scanning electron microscopy. Tissue loss (µm, mean ± standard deviation) in NegContr was 10.9 ± 2.0 (erosion), 22.2 ± 1.6 (erosion-abrasion). Under erosive conditions, only 0.25% HMP in any combination and 1.75% HMP with F/Sn reduced loss significantly (-28% to -54%); 3.25% HMP without F and F/Sn increased loss significantly (+35%). With additional abrasion no suspension reduced loss significantly compared to NegContr, instead, in groups without F and F/Sn or with 3.25% HMP loss was increased (+15% to +30%). Conclusively, at higher concentrations HMP increased erosive tooth wear and seemed to reduce anti-erosive effects of fluoride and stannous ions.

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“…In general, the total amount of tin is determined after conversion to tin(II), tin(IV) or stannane by one of the following methods: atomic absorption spectrometry [1][2][3][4][5][6][7] ; fluorescence 8 ; spectrophotometry [9][10][11][12][13][14][15] ; electrochemistry [16][17][18] and chemilumine-scence 19 . Tin, when present in appreciable amounts, is determined by gravimetric 20 , titrimetric 21 or potentiometric 22 methods. A useful review of the determination of tin in the environment has been compiled by Weber 23 .…”

Section: Research Articlementioning

confidence: 99%

Non-Extractive Spectrophotometric Determination of Sn(II) with 5,7-Dibromo-8-hydroxyquinoline

2017

Chem Sci Trans

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A non-extractive spectrophotometric method is developed for the trace determination of tin(II). The method involves the formation of yellow (1:2) coloured complex 5,7-dibromo-8hydroxyquinoline (DBHQ) in slightly acidic medium. The complex is in aqueous medium (water and ethanol solution) show absorbance at 393 nm. The complex is stable up to 4 days. Beer's law obeyed in the range of 0-9.0 µg Sn mL-1 , molar absorptivity, specific absorptivity and Sandell's sensitivity of complex are 8.133x10 4 L mol-1 cm-1 , 0.4291 mL g-1 cm-1 and 0.00233 µg cm-2 at 393 nm. Potential interferences have been studied. The method is free from interferences of large number of metal ions such as Hg,

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Qualitative and Quantitative Tests for Stannous Fluoride

Cited by 23 publications

References 17 publications

Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

Interaction between Hexametaphosphate, Other Active Ingredients of Toothpastes, and Erosion-Abrasion in Enamel in vitro

Non-Extractive Spectrophotometric Determination of Sn(II) with 5,7-Dibromo-8-hydroxyquinoline

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