Qualitative Assessment of Patients Receiving Prolotherapy for Knee Osteoarthritis in a Multimethod Study

Rabago, David; Leuven, Laura van; Benes, Lane B.; Fortney, Luke; Slattengren, Andrew H.; Grettie, Jessica; Mundt, Marlon

doi:10.1089/acm.2016.0164

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…11,43,44 Prolotherapy has been found to be associated with a favorable side effect profile, high patient satisfaction, and improved knee-specific quality of life and could provide an alternative to pain-relief medications and more invasive surgical interventions such as knee replacement for the management of knee osteoarthritis. 11, 45 The low-quality evidence in support of prolotherapy for the treatment of osteoarthritis has resulted in its classification as a complementary therapeutic intervention. This has led to further attempts to determine if prolotherapy has similar or superior therapeutic efficacy compared to alternative treatments in the treatment of osteoarthritis.…”

Section: Clinical Studies: Effects Of Prolotherapy On Knee Osteoarthr...mentioning

confidence: 99%

A Comprehensive Update of Prolotherapy in the Management of Osteoarthritis of the Knee

Caballero

Nguyen

et al. 2022

Orthopedic Reviews

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This is a comprehensive review of the literature focusing on the use of prolotherapy in the treatment of osteoarthritis of the knee. It covers the background, efficacy, and advantages of prolotherapy in the management of osteoarthritis symptoms and then covers the existing evidence of the use of prolotherapy for this purpose. Current treatments for osteoarthritis of the knee are numerous, yet patients continue to endorse chronic pain and poor quality of life. Prolotherapy is a treatment that has been inadequately studied with poor sample sizes and lack of standardization between trials. However, in recent years the literature on prolotherapy in the treatment of knee osteoarthritis has grown. Although there is still a lack of homogeneity, trials have shown that dextrose prolotherapy, autologous conditioned serum, hyaluronic injections, and normal saline administered either intra- or peri-articularly are comparable in reducing pain scores to other primary treatment options. The mechanism of action for prolotherapy is still unclear, but researchers have found that prolotherapy plays some role in cartilage growth or chondrogenesis and has been shown to have improved radiographic outcomes. Prolotherapy appears to be a safe treatment alternative that has been shown to improve stiffness, pain, function, and quality of life in osteoarthritis of the knee. Knee osteoarthritis is remarkably prevalent in the United States and is one of the most common causes of disability in the elderly population. Although there are many treatment options, patients continue to live with chronic pain which can incur high costs for patients. A safe, long-term, and effective solution has not yet been identified. Prolotherapy has been shown to be a safe option for improving pain, function, and quality of life as effectively as other treatment options.

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Section: Clinical Studies: Effects Of Prolotherapy On Knee Osteoarthr...mentioning

confidence: 99%

A Comprehensive Update of Prolotherapy in the Management of Osteoarthritis of the Knee

Caballero

Nguyen

et al. 2022

Orthopedic Reviews

View full text Add to dashboard Cite

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“…Although there have been more recent studies on the quantitative outcomes of prolotherapy in knee OA, the qualitative assessment of patient experiences after receiving prolotherapy has been less studied. 66 This could be a potential limitation to establishing routine care for knee OA. There is also a lack of familiarity with the procedure and a general fear of injection-based therapy.…”

Section: Qualitative Assessment Of Prolotherapy For Knee Osteoarthritismentioning

confidence: 99%

“…There is also a lack of familiarity with the procedure and a general fear of injection-based therapy. 66 Studies have been done to evaluate perceptions and experiences among those who have received prolotherapy for knee OA. Three randomized control trials (RCTs) and two open label studies reported longitudinal improvement in self-reported knee OA outcomes in response to prolotherapy compared with baselines status, blinded placebo control injections and active treatment.…”

Section: Qualitative Assessment Of Prolotherapy For Knee Osteoarthritismentioning

confidence: 99%

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A comprehensive review of intraarticular knee injection therapy, geniculate injections, and peripheral nerve stimulation for knee pain in clinical practice

et al. 2022

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The knee is the most common joint in adults associated with morbidity. Many pathologies are associated with knee damage, such as gout or rheumathoid arthritis, but the primary condition is osteoarthritis (OA). Not only can osteoarthritis cause significant pain, but it also can result in signficant disability as well. Treatment for this condition varies, starting off with oral analgesics and physical therapy to surgical total knee replacmenet. In the gamut of this various treatments, a conservative approach has included intra articular steroid injections. With time, researchers and clinicians determined that other components injected to the knee may additionally provide relief of this condition. In this investigation, we describe different types of knee injections such as platelet-rich plasma (PRP), hyaluronic acid, stem cells, and prolotherapy. Additionally, we describe the role of geniculate knee injections, radiofrequency, and periopheral nerve stimulation. These treatments should be considered for patients with knee pain refractory to conservative therapies.

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“…Postoperative pain has been acknowledged as one domain (out of many) in perioperative medicine [15] but was not further established. For total knee arthroplasty (and for knee replacement or joint replacement), several initiatives work on harmonizing outcome assessment [11,[16][17][18][19][20][21][22][23][24][25][26][27][28], by considering effects of surgery and general long-term features without focusing on acute postoperative pain (e.g., knee injury and/or knee osteoarthritis, knee, hip, and hand osteoarthritis [16][17][18][19][20][22][23][24][25][26][27][28] or hip or knee osteoarthritis [11,21]). Regarding breast surgery and sternotomy, COS considerations for postoperative pain have not been worked on yet, despite some effort to harmonize outcome assessment in general for reconstructive breast surgery [29,30].…”

Section: Introductionmentioning

confidence: 99%

Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis

Kaiser

Liedgens

Meißner

et al. 2020

Trials

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Introduction Evidence synthesis of clinical trials requires consistent outcome assessment. For pain management after surgery, inconsistency of effectiveness assessment is still observed. A subproject of IMI-PainCare (Innovative Medicine Initiatives, www.imi-paincare.eu) aims for identifying core outcome domains and measurement instruments for postoperative pain in four surgical fields (sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis) in order to harmonize outcome assessment for perioperative pain management. Methods A multifaceted process will be performed according to existing guidelines (Core Outcome Measures in Effectiveness Trials (COMET), COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN)). In a first step, outcome domains will be identified via systematic literature review and consented on during a 1-day consensus meeting by 10 stakeholder groups, including patient representatives, forming an IMI PROMPT consensus panel. In a second step, outcome measurement instruments regarding the beforehand consented core outcome domains and their psychometric properties will be searched for via systematic literature review and approved by COSMIN checklist for study quality and scale quality separately. In a three-step online survey, the IMI PROMPT consensus panel will vote for most suitable measurement instruments. The process is planned to be conducted between 11/2017 (systematic literature review on common outcome domains) and 3/2022 (final voting on core outcome measurement).

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Qualitative Assessment of Patients Receiving Prolotherapy for Knee Osteoarthritis in a Multimethod Study

Cited by 13 publications

References 20 publications

A Comprehensive Update of Prolotherapy in the Management of Osteoarthritis of the Knee

A Comprehensive Update of Prolotherapy in the Management of Osteoarthritis of the Knee

A comprehensive review of intraarticular knee injection therapy, geniculate injections, and peripheral nerve stimulation for knee pain in clinical practice

Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis

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