Qualitative Characterization of Elastic Fiber Distribution in the Mouse Vocal Fold: Further Development of an Animal Model

Marler, Jeffrey A.; Rousseau, Bernard

doi:10.1016/j.jvoice.2009.07.010

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…The ELN gene's protein, elastin, is the most abundant element in elastic fibers, directly influencing smooth muscle cell development, adhesion, and proliferation [Urban et al, 2001, 2002; Kielty, 2006]. Elastin is also found in the ligaments, skin, cartilages of the ear, the epiglottis, larynx, and the muscles of the vocal folds [Keith, 1980; Hahn et al, 2006; Kusuhara et al, 2009; Watts et al, in press]. Elastic fibers play an important role in craniofacial development.…”

Section: Discussionmentioning

confidence: 99%

Auditory function and hearing loss in children and adults with Williams syndrome: Cochlear impairment in individuals with otherwise normal hearing

Marler

Sitcovsky

Mervis

et al. 2010

American J of Med Genetics Pt C

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Hearing loss is common in school-age individuals with Williams syndrome (WS) and extensive in adults. Prior studies with relatively small sample sizes suggest that hearing loss in WS has an early onset and may be progressive, yet the auditory phenotype and the scope of the hearing loss have not been adequately characterized. We used standard audiometric tools: Otoscopy, tympanometry, air-conduction (bone conduction when available) behavioral testing, and distortion product otoacoustic emissions (DPOAEs) to measure hearing sensitivity and outer hair cell function. We tested 81 individuals with WS aged 5.33 to 59.50 years. 63% of the school-age and 92% of the adult participants had mild to moderately-severe hearing loss. The hearing loss in at least 50% was sensorineural. DPOAE testing corroborated behavioral results. Strikingly, 12 of 14 participants with hearing within normal limits bilaterally had 4000-Hz DPOAE input/output (DPOAE IO) functions indicative of outer hair cell damage and impaired cochlear compression. Our results indicate that hearing loss is very common in WS. Furthermore, individuals with WS who have “normal” hearing as defined by behavioral thresholds may actually have sub-clinical impairments or undetected cochlear pathology. Our findings suggest outer hair cell dysfunction in otherwise normal hearing individuals. The DPOAE IO in this same group revealed growth functions typically seen in groups with noise-induced damage. Given this pattern of findings, individuals with WS may be at increased risk of noise-induced hearing loss. Recommendations regarding audiological testing for individuals with WS and accommodations for these individuals in both academic and nonacademic settings are provided.

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Section: Discussionmentioning

confidence: 99%

Auditory function and hearing loss in children and adults with Williams syndrome: Cochlear impairment in individuals with otherwise normal hearing

Marler

Sitcovsky

Mervis

et al. 2010

American J of Med Genetics Pt C

Self Cite

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“…Larynges harvested from the CSE, REV, and control groups were fixed in 4% paraformaldehyde overnight at 4 °C, transferred to 70% ethanol, and sent to HistoWiz, Inc. ( http://www.histowiz.com ; Brooklyn, NY) for tissue processing, paraffin embedding, and microtomy per established methods [ 58 , 59 ]. A small portion of trachea was left on the larynx as an anatomical landmark for orientation during paraffin embedding.…”

Section: Methodsmentioning

confidence: 99%

Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

et al. 2021

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“…This study appreciates human laryngeal behavior in the comparative context of mammalian behavior. Our research efforts specifically contribute to recent efforts to characterize rodent laryngeal anatomy for biomedical research (e.g., Lungova et al, 2015;Thomas et al, 2009;Watts et al, 2011) by characterizing development of the laryngeal cartilaginous skeleton in several rodent species employing novel methodology to address questions of growth and function.…”

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confidence: 99%

Postnatal Development of the Mouse Larynx: Negative Allometry, Age-Dependent Shape Changes, Morphological Integration, and a Size-Dependent Spectral Feature

Riede

Coyne

Tafoya

et al. 2020

J Speech Lang Hear Res

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Purpose The larynx plays a role in swallowing, respiration, and voice production. All three functions change during ontogeny. We investigated ontogenetic shape changes using a mouse model to inform our understanding of how laryngeal form and function are integrated. We understand the characterization of developmental changes to larynx anatomy as a critical step toward using rodent models to study human vocal communication disorders. Method Contrast-enhanced micro-computed tomography image stacks were used to generate three-dimensional reconstructions of the CD-1 mouse ( Mus musculus ) laryngeal cartilaginous framework. Then, we quantified size and shape in four age groups: pups, weanlings, young, and old adults using a combination of landmark and linear morphometrics. We analyzed postnatal patterns of growth and shape in the laryngeal skeleton, as well as morphological integration among four laryngeal cartilages using geometric morphometric methods. Acoustic analysis of vocal patterns was employed to investigate morphological and functional integration. Results Four cartilages scaled with negative allometry on body mass. Additionally, thyroid, arytenoid, and epiglottic cartilages, but not the cricoid cartilage, showed shape change associated with developmental age. A test for modularity between the four cartilages suggests greater independence of thyroid cartilage shape, hinting at the importance of embryological origin during postnatal development. Finally, mean fundamental frequency, but not fundamental frequency range, varied predictably with size. Conclusion In a mouse model, the four main laryngeal cartilages do not develop uniformly throughout the first 12 months of life. High-dimensional shape analysis effectively quantified variation in shape across development and in relation to size, as well as clarifying patterns of covariation in shape among cartilages and possibly the ventral pouch. Supplemental Material https://doi.org/10.23641/asha.12735917

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Qualitative Characterization of Elastic Fiber Distribution in the Mouse Vocal Fold: Further Development of an Animal Model

Cited by 11 publications

References 27 publications

Auditory function and hearing loss in children and adults with Williams syndrome: Cochlear impairment in individuals with otherwise normal hearing

Auditory function and hearing loss in children and adults with Williams syndrome: Cochlear impairment in individuals with otherwise normal hearing

Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

Postnatal Development of the Mouse Larynx: Negative Allometry, Age-Dependent Shape Changes, Morphological Integration, and a Size-Dependent Spectral Feature

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