Qualitative cross-cultural exploration of vaginal bleeding/spotting symptoms and impacts associated with hormone therapy in post-menopausal women to inform the development of new patient-reported measurement tools

Arbuckle, Rob; Humphrey, L.; Abraham, Lucy; Dennerstein, Lorraine; Simon, James A.; Mirkin, Sebastián; Bonner, Nicola; Walmsley, Steven; Tatlock, Sophi; Symonds, Tara

doi:10.1016/j.maturitas.2014.04.019

Cited by 13 publications

(6 citation statements)

References 14 publications

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“…Among individuals who reported vulvovaginal symptoms, CI and CASI survey modes were moderately concordant. In contrast to previous studies which found CASI had a higher frequency of responses (albeit to questions on sexual behaviors [18][19][20][21][22][23][24][25] and menstruation, [26][27][28] rather than specific vulvovaginal symptoms), we found CI resulted in slightly more responses than CASI, although the differences were not statistically significant. Our findings also indicated that when a participant reported not having symptoms on CASI, they were likely to indicate no symptoms to CI, and thus, concordance between interview modes was high because of the large majority with negative reporting.…”

Section: Discussioncontrasting

confidence: 99%

Comparison of Computer-Assisted Self-Interview Versus Clinician Interview for Self-Reported Vulvovaginal Symptoms

et al. 2023

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This secondary analysis (N = 43) compared computer-assisted self-interview (CASI) to clinician interview for self-report of 8 vulvovaginal symptoms. Concordance was moderate between interview modes (range, 70-86%) with itching and odor having highest agreement. Although prior reports suggest more responses on CASI, we found CASI did not significantly increase self-report of symptoms over clinician interview.

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Section: Discussioncontrasting

confidence: 99%

Comparison of Computer-Assisted Self-Interview Versus Clinician Interview for Self-Reported Vulvovaginal Symptoms

et al. 2023

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“…Many women with bothersome VMS remain untreated or use nonprescription medications, herbal supplements or alternative therapies [15][16][17]. Factors influencing treatment decisions include safety and tolerability (e.g., breast cancer, stroke, venous thromboembolism, breast tenderness, vaginal bleeding) related to long-term HT use [18][19][20][21][22] and moderate efficacy of non-hormonal treatments [10]. Although previous studies have examined the burden of VMS associated with menopause [7,8], a more comprehensive understanding of VMS burden and patient/physician perspectives on its management is needed.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the impact, treatment patterns, and patient and physician perceptions of vasomotor symptoms associated with menopause in Europe and the United States

et al. 2022

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“…Concerns about long-term safety of hormone therapy and moderate efficacy of available nonhormone treatment for VMS may be contributing to low usage rates of these therapies. [45][46][47][48][49][50] Therefore, new therapies that are safe and effective in reducing hot flashes and night sweats could be beneficial in improving sleep quality among women with VMS.…”

Section: Depree Et Almentioning

confidence: 99%

Association of menopausal vasomotor symptom severity with sleep and work impairments: a US survey

DePree,

Shiozawa,

King

et al. 2023

Menopause

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Objective Menopausal vasomotor symptoms commonly disrupt sleep and affect daytime productivity. This online survey evaluated associations between vasomotor symptom severity and perceived sleep quality and work productivity. Methods Participants were perimenopausal or postmenopausal US women aged 40 to 65 years with ≥14 vasomotor symptom episodes per week for ≥1 week in the past month. The women, who were recruited from Dynata panels via email invitation and categorized by vasomotor symptom severity based on the Menopause Rating Scale, were surveyed about sleep and work productivity and completed the Patient-Reported Outcomes Measurement Information System Sleep Disturbance Short Form 8b (primary outcome) and Sleep-Related Impairment Short Form 8a, Pittsburgh Sleep Quality Index, and Work Productivity and Activity Impairment questionnaire. Results Among 619 respondents (mean age, 53 y; White, 91%; perimenopausal, 34%; postmenopausal, 66%; 57.5% were never treated for vasomotor symptoms), vasomotor symptoms were mild in 88, moderate in 266, and severe in 265. A majority (58% overall) were employed, including 64.8%, 49.6%, and 64.2% of women with mild, moderate, and severe VMS, respectively. Of the 90.8% who reported that vasomotor symptoms affect sleep (81.8%, 86.8%, and 97.7% of those with mild, moderate, and severe VMS), 83.1% reported sleep-related changes in productivity (75.0%, 73.2%, and 94.2%, respectively). Patient-Reported Outcomes Measurement Information System Sleep Disturbance Short Form 8b mean T scores in the mild (T score, 53.5), moderate (57.3), and severe (59.8) VMS cohorts indicated more sleep disturbance than in the general population (T score, 50; overall P < 0.001 before and after controlling for confounding variables). Sleep-Related Impairment 8a results were similar. Vasomotor symptom severity was positively associated with Pittsburgh Sleep Quality Index mean scores, presenteeism, absenteeism, overall work impairment, and impairment in general activities. Conclusions Greater vasomotor symptom severity was associated with more sleep disturbance, more sleep-related impairment, worse sleep quality, and greater impairment in daytime activities and work productivity.

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Qualitative cross-cultural exploration of vaginal bleeding/spotting symptoms and impacts associated with hormone therapy in post-menopausal women to inform the development of new patient-reported measurement tools

Cited by 13 publications

References 14 publications

Comparison of Computer-Assisted Self-Interview Versus Clinician Interview for Self-Reported Vulvovaginal Symptoms

Comparison of Computer-Assisted Self-Interview Versus Clinician Interview for Self-Reported Vulvovaginal Symptoms

Evaluation of the impact, treatment patterns, and patient and physician perceptions of vasomotor symptoms associated with menopause in Europe and the United States

Association of menopausal vasomotor symptom severity with sleep and work impairments: a US survey

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