Qualitative identification of the active principles in Citrullus colocynthis and evaluation of its teratogenic effects in albino rats

Elgerwi, A.; Benzekri, Z.; El-Magdoub, A.; El-Mahmoudy, Abubakr

doi:10.5455/2319-2003.ijbcp20130818

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Alkaloids 0.025 g of crude extracts were dissolved in 20 mL of 5% hydrochloric acid (HCl) and sonicated to improve solubitity. The mixture was used to determine with the following test; 38…”

Section: Phytochemical Screening Of the Extractsmentioning

confidence: 99%

Phytochemicals, Antioxidants and Anti-tyrosinase Analyses of Selected Ginger Plants

Rachkeeree¹,

Kantadoung²,

Puangpradub³

et al. 2020

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Background: Some of Zingeberaceae are not widely used for medicine of food, although in Thailand have been used them for many reasons about health or the diet. This study evalued the phytochemicals and anti-tyrosinase activities of 16 plant species of Alpinia, Amomum, Curcuma, Etlingera and Kaemferia (Zingiberaceae). Methods: The extractions of dried powdered rhizomes were performed using n-hexane, ethylacetate and ethanol. Percentage extract yield of the samples varied among species and solvent extracts. Chemical groups (alkaloids, flavonoids, tannins, polyphenols, steroids and terpenoids) were identified using phytochemical screening. The total phenolic contents (TPC) were analyzed using the Folin-Ciocalteu's reagent, while antioxidant activities were detected using 2,2-diphenyl-1picrylhydrazyl (DPPH) and the 2,2'-azino-bis (3-ethylbenzothizoline-6-sulphonic acid) (ABTS .+ ). The anti-tyrosinase was expressed to the half maximal inhibitory concentration (IC 50 ) value (mg/mL). Results: The ethyl acetate extract of Amomum showed the highest value of TPC. The strongest antioxidant activity were found in Amomum and Kaemferia extracts, while ethyl acetate and ethanol extracts of all samples have a better antioxidant properties than the n-hexane extracts. On the other hand, the n-hexane extracts have the highest anti-tyrosinase potential in all samples and of these, Curcuma extracts were the best group. Conclusion: Our research indicated that plants of the Zingiberaceae would be new sources of antioxidants and anti-tyrosinase for further natural product developments in cosmetics, food or nutraceuticals.

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Section: Phytochemical Screening Of the Extractsmentioning

confidence: 99%

Phytochemicals, Antioxidants and Anti-tyrosinase Analyses of Selected Ginger Plants

Rachkeeree¹,

Kantadoung²,

Puangpradub³

et al. 2020

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“…The study displayed treatogenic effects, when gross anatomical observation is done on the 20th day of gestation it revealed a high percentage of resorbed fetuses, smaller size and weight fetuses as well as absence of coccygeal vertebrae, metacarpal and metatarsal bones, and carpal and tarsal bones. (75).…”

Section: Toxicitymentioning

confidence: 99%

Citrullus colocynthis (L.) Schrad (Bitter Apple): An Overview of its Traditional Uses, Phytochemistry and Pharmacological Potential

Kamboj

Singh

2022

Serbian Journal of Experimental and Clinical Research

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Citrullus colocynthis (L.) Schrad is an important cucurbit plant, commonly distributed in the sandy areas of the world. In the Indian continent it is mainly found in the North West, the Punjab and in Central and southern India. The Citrullus colocynthis plant is usually known for its traditional uses as a remedy in the treatment of asthma, diabetes, common cold, leprosy, cough, bronchitis, joint pain, jaundice, cancer, toothache, mastitis, and in gastrointestinal disorders such as gastroenteritis, indigestion, dysentery, constipation, colic pain and other microbial infections. Phytochemicaly the compounds like glycosides, alkaloids, flavonoids, phenolic acids fatty acids, carbohydrates and essential oils were reported from the plant and the main components isolated from the Citrullus colocynthis plant are Cucurbitacins. The plant has been studied extensively for its wide range of pharmacological activities, which include anticancer, antidiabetic, antioxidant, cytotoxic, antimicrobial, anti-inflammatory antilipidemic, and insecticide but the therapeutic potential for cardiovascular, gut, airways and many other diseases remain to be explored.

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“…In addition, moderate to severe hypotension, moderate hypoglycemic, and hepatic injury with increasing of hepatic enzymes were recorded in a case of acute C. colocynthis toxicity (Table 2). Moreover, the extract of fruit pulp of C. colocynthis was reported to cause teratogenic effects if given during the early stage of pregnancy in rats [121]. Studying the effects of 100 or 200 mg/kg/day of either pulp or seed extracts of C. colocynthis on male rabbits, for one month, indicated that 200 mg/kg/day of pulp extract was fatal for all animals and 50% of animals treated with pulp extract at 100 mg/kg/day did not survive to the end of the study.…”

Section: Sansevieria Trifasciata Prainmentioning

confidence: 99%

A Review on Some Cultivated and Native Poisonous Plants in Aden Governorate, Yemen

Alasbahi

Al-Hawshabi

2021

Electron. J. Univ. Aden Basic Appl. Sci.

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Plant poisoning is a health concern in many countries where plants are used either accidently, especially among children, or intentionally for purposes such as assassination, suicide, hunting, fishing and treating various diseases. Presently, despite the implementation of toxicology surveillance systems in many countries, plant poisoning continues to be a preventable cause of morbidity and mortality. In the Aden governorate of Yemen, there are no laws or regulations for the prevention of plant poisoning, despite the existence of several poisonous species in gardens, and as roadside trees planted by the local authority, or growing wildly in public areas. In addition, there is a lack of scientific studies on the risks of these poisonous plants. Therefore, we undertook this study, based on scientific review, to document and illustrate the botanical, geographical and toxicological characteristics of fourteen poisonous plants collected from different districts of Aden governorate. The documented poisonous species (6 species) belong to Apocynaceae followed by Fabaceae (2 species), whereas Aristolochiaceae, Cucurbitaceae, Dracaenaceae, Euphorbiaceae, Meliaceae, and Verbenaceae are represented by one species each. The toxic parts of the majority of studied poisonous species are the whole plant, latex, seeds, and fruits. Cardiotoxicity, cytotoxicity, gastrointestinal toxicity, and inflammation of skin and mucous membrane are the main clinical manifestations. They are caused by varying amounts of plant toxins such as cardiac glycosides in Calotropis procera, Cryptostegia grandiflora, Nerium oleander and Thevetia peruviana, and cytotoxic toxins such as toxalbumins in Abrus precatorius and Ricinus communis, aristolochic acids in Aristolochia bracteolate, and vinca alkaloids in Catharanthus roseus, as well as gastrointestinal toxins such as cucurbitacins in Citrullus colocynthis, and tannins in Caesalpinia pulcherrima. Inflammation of skin and mucous membrane is caused by calcium oxalate crystals in Calotropis procera latex, and soluble protein in Cryptostegia grandiflora latex. Moreover, Azadirachta indica caused a number of toxicities attributed partially to tetranortriterpenoids, while Sansevieria trifasciata toxicity was reported to be low. The significance of this work is to promote the awareness among the local authority to take legal actions against plant poisoning. In addition, it provides the physicians with scientific information for the diagnosis and treatment of poisoning by some plants. It is hoped that this study motivates researchers to conduct further research on poisonous plants throughout Yemen.

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Qualitative identification of the active principles in Citrullus colocynthis and evaluation of its teratogenic effects in albino rats

Cited by 4 publications

References 6 publications

Phytochemicals, Antioxidants and Anti-tyrosinase Analyses of Selected Ginger Plants

Phytochemicals, Antioxidants and Anti-tyrosinase Analyses of Selected Ginger Plants

Citrullus colocynthis (L.) Schrad (Bitter Apple): An Overview of its Traditional Uses, Phytochemistry and Pharmacological Potential

A Review on Some Cultivated and Native Poisonous Plants in Aden Governorate, Yemen

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