Qualitative study on diabetic cutaneous wound healing with radiation crosslinked bilayer collagen scaffold in rat model

Li, Hongwei; Chen, Xin; Ren, Kang; Wu, Lihao; Gong, Chen; Xu, Ling

doi:10.1038/s41598-023-33372-z

Cited by 7 publications

(1 citation statement)

References 45 publications

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“…Collagen and chitosan-based sponges are the most commonly used scaffolds for MSC delivery[ 200 ]. As for the usage of SLS in diabetic wound treatment, collagen scaffold derived from bovine skin has been shown to result in improved biocompatibility, re-epithelization, anti-inflammatory effects, and neovascularization of chronic wounds in diabetic mice[ 215 , 216 ]. Studies performed on MSCs and exosomes have further showed that the combination of gingival MSC-derived exosomes and hydrogel sponges accelerates skin wound healing and the re-epithelization process[ 217 ].…”

Section: Diabetes Comorbiditiesmentioning

confidence: 99%

Alternative therapeutic strategies in diabetes management

Annicchiarico,

Barile,

Buccoliero

et al. 2024

World J Diabetes

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Diabetes is a heterogeneous metabolic disease characterized by elevated blood glucose levels resulting from the destruction or malfunction of pancreatic β cells, insulin resistance in peripheral tissues, or both, and results in a non-sufficient production of insulin. To adjust blood glucose levels, diabetic patients need exogenous insulin administration together with medical nutrition therapy and physical activity. With the aim of improving insulin availability in diabetic patients as well as ameliorating diabetes comorbidities, different strategies have been investigated. The first approaches included enhancing endogenous β cell activity or transplanting new islets. The protocol for this kind of intervention has recently been optimized, leading to standardized procedures. It is indicated for diabetic patients with severe hypoglycemia, complicated by impaired hypoglycemia awareness or exacerbated glycemic lability. Transplantation has been associated with improvement in all comorbidities associated with diabetes, quality of life, and survival. However, different trials are ongoing to further improve the beneficial effects of transplantation. Furthermore, to overcome some limitations associated with the availability of islets/pancreas, alternative therapeutic strategies are under evaluation, such as the use of mesenchymal stem cells (MSCs) or induced pluripotent stem cells for transplantation. The cotransplantation of MSCs with islets has been successful, thus providing protection against proinflammatory cytokines and hypoxia through different mechanisms, including exosome release. The use of induced pluripotent stem cells is recent and requires further investigation. The advantages of MSC implantation have also included the improvement of diabetes-related comorbidities, such as wound healing. Despite the number of advantages of the direct injection of MSCs, new strategies involving biomaterials and scaffolds have been developed to improve the efficacy of mesenchymal cell delivery with promising results. In conclusion, this paper offered an overview of new alternative strategies for diabetes management while highlighting some limitations that will need to be overcome by future approaches.

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Section: Diabetes Comorbiditiesmentioning

confidence: 99%

Alternative therapeutic strategies in diabetes management

Annicchiarico,

Barile,

Buccoliero

et al. 2024

World J Diabetes

View full text Add to dashboard Cite

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Effect of radiation cross‐linked collagen scaffold in alveolar ridge preservation of extraction socket

Li,

Yang,

Chen

et al. 2024

J Biomedical Materials Res

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This study aimed to evaluate the properties of radiation cross‐linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze‐drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty‐four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro‐computed tomography (micro‐CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge height at buccal and palatal side, in ridge width and in micromorphological parameters. Histological analysis accessed socket microarchitecture. The results showed that RCS had stable mechanical properties and morphologic features that provided a reliable physical support for ARP. Dimensional changes in treatment group revealed significantly greater vertical height at buccal (5.32 [3.37, 7.26] mm, p < .0001) and palatal (4.37 [2.66, 6.09] mm, p < .0001) side, and horizontal width at the maxilla (0.16 [0.04, 0.28] mm, p < .01) and mandible (0.33 [0.11, 0.54] mm, p < .01) than those in sham operation group after 12 weeks. The treatment group had advantage than positive group in vertical height preservation, quantitatively. The order and density of bone trabeculae were improved in treatment group. These findings indicated that RCS had the potential to serve as an effective scaffold for ARP.

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