Quality and Toxicity Assessment of some Oral Liquid Herbal Formulations (Agbo) consumed in Abuja, Nigeria

Olayemi, Olubunmi; Oladosu, Peters; Samali, Ayuba; Onogwu, David; Ijele, Ibrahim; Kunle, Olobayo O.

doi:10.5455/jcmr.2021.12.01.04

Cited by 1 publication

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“…Unfortunately, adverse effects such as constipation, diarrhoea, dizziness, dry mouth, abdominal cramps, edema, development of tolerance and incidence of relapses of these drugs affect patient compliance and ultimately overall therapy (Alhammadi et al, 2020). This has led to investigations of alternative pharmacologically active leads such as crude plant extracts which are cheap, readily available, better cultural acceptability and have relatively fewer side effects making it a desirable, better and safer approach (Olayemi et al, 2021). Plants have been used for treatment of various diseases from medieval times and their uses are being passed down from generation to generation.…”

Section: Introductionmentioning

confidence: 99%

Preliminary physicochemical evaluation of effervescent granules of Anogiessius leocarpus stem bark extract

Olayemi,

Morka,

Adesola

2023

jcbr

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The plant Anogeissus leiocarpus is traditionally used in the treatment of ulcers including gastric ulcers. Effervescent granules are unique, pleasant-tasting oral formulations which are ingested as liquids. This study is a preliminary development and evaluation of effervescent granules of the aqueous extract of the stem bark of Anogeissus leiocarpus. The extract was obtained by drying the filtrate gotten from maceration of the dried, crushed stem bark in water. The acids (citric and tartaric acid) were each combined with the base (sodium bicarbonate) in 1:1 and 1:2 ratios and these were mixed with the extract using either the fusion or wet granulation method of preparation of effervescent granules. The granules were evaluated for their flow properties, moisture content, pH after dissolution, effervescent time and in vitro dissolution. Results show that granules prepared by the fusion method possessed better flow properties than those prepared by wet granulation. Moisture content of the granules was similar. Granules containing higher base content had higher pH (7.29 and 7.30) and faster effervescent time (86 -99 sec) than those containing equal ratio of acid and base with pH of 5.85 and 5.96 and effervescent time of 104 -150 sec. In vitro release was faster release from formulations containing higher base content (100 and 90.32 % respectively) than the other batches. Aqueous extract of the stem bark of Anogeissus leiocarpus can be suitably formulated into effervescent granules.

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Section: Introductionmentioning

confidence: 99%