Quality aspects in the development of pelletized dosage forms

Agrawal, Surendra; Fernandes, Joneth; Shaikh, Fuzail; Patel, V. B.

doi:10.1016/j.heliyon.2022.e08956

Cited by 15 publications

(10 citation statements)

References 106 publications

(172 reference statements)

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“…Additionally, a high fiber content in the material might make the pellet break easily, resulting in a low durability index rating. Agrawal et al [ 26 ] further stated that the diameter of the pellet is another element that may impact its durability; compared to pellets with a 6 mm diameter, those with a diameter of 3 mm are simpler to break.…”

Section: Resultsmentioning

confidence: 99%

Maintaining the physical quality and digestibility of pellet feed through the use of plant-based pellet binder

Jaelani,

Rostini,

Zakir

et al. 2024

J Adv Vet Anim Res

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Objectives: This study aimed to analyze the effects of the use of binders on the physical quality and digestibility of Alabio ducks (Anas platyrinchos Borneo). Materials and Methods: Pellet binders used tapioca meal (TM) (Manihot utilissima), sago meal (SM) (Metroxylon sagu Rottb.), and sweet potato meal (SPM) (Ipomoea batatas) pelleted feed. Laying Alabio ducks, around 120 birds, aged 20 weeks with an average body weight of 1,426 ± 113.5 gm, were used. A fully randomized design with 4 treatments and 15 repeats was used in this study. The variables measured include the physical quality and digestibility of pellet feed. Data analysis used a Fisher test. For the distinction between treatments, the Duncan multiple-range test was conducted. Results: The finding showed that the plant-based pellet binder had a natural effect on physical properties, including pellet durability index, moisture content, threshold power, stack density, and stack compacted density. The strength of the pellet binder is seen in the durability index of TM 98.12%, SM 97.64%, and SPM 97.35%, respectively. However, these variables did not differ significantly in terms of specific gravity and stack angle. Pellet binders considerably affect the consumption of feed and vary markedly in dry matter, organic matter, and metabolizable energy digestibility. Conclusion: Plant-based pellet binders influence the physical quality and digestibility of pelleted feed in Alabio ducks. TM can maintain physical quality and digestibility compared to SM and SPM as plant-based pellet binders.

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Section: Resultsmentioning

confidence: 99%

Maintaining the physical quality and digestibility of pellet feed through the use of plant-based pellet binder

Jaelani,

Rostini,

Zakir

et al. 2024

J Adv Vet Anim Res

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“…Raw material is the material basis for the preparation of pellets via the extrusion rounding method, and the extrudate, as the precursor of pellets, has a direct impact on the molding quality of pellets. The literature research [3][4][5][6][7][8][9][10][11] shows that the smoother the surface of the extrudate, the better the molding quality of the pellet, which is an important guiding significance for the preparation of pellets via the extrusion and rounding method. Researchers in traditional Chinese medicine basically follow the above theory when conducting studies of pellets found in traditional Chinese medicine [12][13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…When preparing pellets with pure microcrystalline cellulose (MCC) as the raw material, it is widely believed that the smoother the surface of the extrusion, the better the quality of the pellets prepared. The pellets prepared with a smooth extrusion surface have a high yield, good roundness, and a small particle size distribution [3][4][5][6][7][8][9]. Using different pellet preparation techniques also showed that the pellets obtained from extrudates with smooth surfaces had larger particle size, higher density, better fluidity, and characteristics of slow release and controlled release [10,11].…”

Section: Introductionmentioning

confidence: 98%

Influence of Extrudate-Based Textural Properties on Pellet Molding Quality

Tian,

Li,

et al. 2023

Pharmaceuticals

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As the precursor of pellets, the extrudate has a direct impact on the molding quality of the pellets. Therefore, the correlation between the surface roughness of the extrudates and the molding quality of pellets with pure microcrystalline cellulose (MCC) formulations and those containing traditional Chinese medicine (TCM) formulations was explored. MCC was used as a pelleting agent, mixer torque rheometry (MTR) was used to guide the optimal dosage of the wetting agent, and TCM extracts (drug loadings of 20% to 40%) were selected as model drugs to prepare the extrudates and pellets under the same extrusion spheronization process conditions. The surface roughness and texture parameters of extrudates were analyzed via a microscope and texture analyzer, respectively, and the quality of pellets was evaluated. The extrudate roughness of the pure MCC prescription decreased and then increased with increasing water addition, while the extrudate roughness of the prescription containing TCM extracts tended to increase and then decrease. The addition of water affected the extrudate properties, with TCM extract molecules filling gaps in the MCC structure, leading to rough surfaces. The extrudate roughness of the TCM prescriptions was significantly greater than that of the pure MCC prescriptions at optimal water addition levels, resulting in ideal pellets.

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“…Release of molecules from carriers is of interest in the context of basic science and from the perspective of applications in various fields ranging from medicine (e.g., drug and vaccine delivery by macroscopic pellets and nanocarriers) to energetics (e.g., hydrogen storage and sensors). This process can be limited by the diffusion of atoms or molecules in carriers or kinetically limited by processes at and/or near the interface between a carrier and the external medium .…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Limited Release of Molecules from Nanocarriers with Appreciable Energetic Heterogeneity

Zhdanov

2024

J. Phys. Chem. C

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Carriers with a size of ∼100−200 nm are now used in various applications related, e.g., to drug and vaccine delivery. Such carriers are structurally heterogeneous, and this results in appreciable energetic heterogeneity for the diffusion of cargo molecules. In particular, the diffusion coefficient becomes dependent on the concentration of molecules, and this dependence is related to the distribution of attachment sites over binding energy. Taking this distribution into account and integrating the corresponding diffusion equation, the author shows that in this case, the release kinetics are logarithmic. Such kinetics can be fitted by employing the Weibull expression with the exponent in the range of 0.35 to 0.45. This range is relevant in the context of recent experiments with nanocarriers.

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Quality aspects in the development of pelletized dosage forms

Cited by 15 publications

References 106 publications

Maintaining the physical quality and digestibility of pellet feed through the use of plant-based pellet binder

Maintaining the physical quality and digestibility of pellet feed through the use of plant-based pellet binder

Influence of Extrudate-Based Textural Properties on Pellet Molding Quality

Diffusion-Limited Release of Molecules from Nanocarriers with Appreciable Energetic Heterogeneity

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