The study aimed to describe and test machine learning (ML)-based algorithms to evaluate the unit price of drinking milk. The algorithms were applied to the data collected over 8 years in 2014 and 2021 related to the price of drinking milk in Turkey. The economic, social, and environmental factors that have an impact on the unit price of drinking milk were evaluated. Five ML algorithms, including random forest, gradient boosting, support vector machine (SVM), neural network, and AdaBoost algorithms, were utilized to predict the drinking milk unit price. ML also applied hyperparameter tuning with nested cross-validation to calculate the prediction accuracy for each algorithm. The results show that the random forest algorithm based on the features of the ML algorithms has the best performance, with the accuracy of 99.30% for training and 98.10% for testing the dataset. The average accuracy of gradient boosting, SVM, neural network, and AdaBoost are obtained as 97.30%, 96.15%, 95.65%, and 96.05%, respectively. Random forest performed best as the target variable with the lowest deviation values of mean squared error (MSE) (0.004), root mean square error (RMSE) (0.060), and mean