Quality by Design (QbD) based Formulation Optimization of Isoniazid Loaded Novel Nanostructured Lipid Carriers for Controlled Release Effect

Ahalwat, Shaveta; Bhatt, Dinesh Chandra; Rohilla, Surbhi

doi:10.1007/s12247-023-09749-y

Cited by 3 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its compatibility with a cubosome lipid nanocarrier used for encapsulating was investigated by the DSC scan analysis of thermograms for the components and their complex. Another variant of the lipid-based encapsulation of antibiotics (including the "classic" first-line drug isoniazid) was proposed in the work [169]; the DSC provided an opportunity to characterise the optimised compatibility of drug and lipids in the composition. The specific form of drug delivery in the form of co-spray-dried powders comprised of the different compositions of capreomycin (a semisynthetic antibiotic) and antimicrobial peptides (i.e., biomolecules) for pulmonary delivery was characterised with DSC in the work [170].…”

Section: Dsc Of Molecules Of a Cell Wall And Interaction With Themmentioning

confidence: 99%

Accessing Properties of Molecular Compounds Involved in Cellular Metabolic Processes with Electron Paramagnetic Resonance, Raman Spectroscopy, and Differential Scanning Calorimetry

Postnikov,

Wasiak,

Bartoszek

et al. 2023

Molecules

View full text Add to dashboard Cite

In this work, we review some physical methods of macroscopic experiments, which have been recently argued to be promising for the acquisition of valuable characteristics of biomolecular structures and interactions. The methods we focused on are electron paramagnetic resonance spectroscopy, Raman spectroscopy, and differential scanning calorimetry. They were chosen since it can be shown that they are able to provide a mutually complementary picture of the composition of cellular envelopes (with special attention paid to mycobacteria), transitions between their molecular patterning, and the response to biologically active substances (reactive oxygen species and their antagonists—antioxidants—as considered in our case study).

show abstract

Section: Dsc Of Molecules Of a Cell Wall And Interaction With Themmentioning

confidence: 99%

Accessing Properties of Molecular Compounds Involved in Cellular Metabolic Processes with Electron Paramagnetic Resonance, Raman Spectroscopy, and Differential Scanning Calorimetry

Postnikov,

Wasiak,

Bartoszek

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box-Behnken Design

Mane,

Killedar,

et al. 2024

Journal of Chemistry

View full text Add to dashboard Cite

Purpose. The present study aimed to improve the aqueous solubility, permeability, bioavailability, and nootropic potential of standardized Emblica officinalis extract (EOE) by developing a novel phytosomal formulation. Method. Emblica officinalis extract-loaded phytosomes (EOPs) were prepared using solvent evaporation. The EOP was prepared at different molar ratios of extract and phospholipid. Herein, the effects of phospholipid extract ratio (A), temperature (B), and reaction time (C) were systematically investigated on entrapment efficiency using Box-Behnken design. In vitro and in vivo characterizations of the optimized formulation were performed. Results. Optimized EOP formulation (89.90 ± 0.24 μg/ml) exhibited improved aqueous solubility than plain EOE (11.85 ± 0.25 μg/ml). The optimized formulation’s particle size and Zeta potential were 198.4 ± 0.20 nm and −39.0 ± 0.40 mv. DSC and XRD studies confirmed the partial amorphization of EOE in phytosomes. Optimized formulation exhibited 69.82 ± 0.17% of EOE release at 12 h and followed zero-order release kinetics. Moreover, the phytosomal formulation of EOE exhibited its rationality with an improvement of bioavailability by 2.7 folds compared with pure EOE. Compared to EOE, EOP showed significantly (p<0.05 lower escape and transfer latencies on both days in MWMT and EPMT, indicating more effective memory-enhancing activity. Furthermore, EOP-treated rats exhibited improved acetylcholine (Ach) levels than EOE. Brain tissue concentrations measured following EOP oral administration (1.06 ± 0.04 μg/ml) were substantially greater (p<0.05) than those following EOE (0.32 ± 0.07 μg/ml). The brain dopamine and serotonin concentration were found to be higher (16.27 ± 1.209 and 43.28 ± 1.550 ng/ml) in the EOP-treated group as compared to the pure extract-treated group (10.40 ± 1.185 and 32.79 ± 1.738 ng/ml). Conclusion. Improvement of aqueous solubility, permeability, dissolution, bioavailability, and narrower particle size distribution could facilitate enhancement in the nootropic potential of EOE phytosomal formulation.

show abstract

Quality by Design (QbD) based Formulation Optimization of Artemether Loaded Mucoadhesive Nanoemulsion for Intranasal Delivery

Rani,

Gupta,

Bhatt

et al. 2024

RJPT

View full text Add to dashboard Cite

Artemether is a first choice of drug used in the treatment of cerebral malaria and often used in combination.The objective of this work was to precisely design a nanoemulsion formulation for controlled release effect. The brain uptake of the drugcan be increased throughintranasal drug delivery and enhances the bioavailability by preventing the hepatic first-pass metabolism. Oleic acid was used as an oily phase as the drug exhibited maximum solubility in it.The tween 80, propylene glycol 400 were finalizedas surfactants and co-surfactants respectively based on the miscibility study. The optimization was carried out for various dependent and independent variables using Design Expert software. The optimized formulation was evaluated by various evaluation parameters. The polydispersity index (PDI) and zeta potential (ZP) were determined as 0.484±0.026 and +21±1.44mV respectively. The optimized formulation consisted of entrapment efficiency of 91.5%, globule size of 14.49nm, viscosity of 29cPas, and pH of 6.4. It showed a drug release of 93.17% in 24 hours representing the controlled drug release effect as it showed greatest R2 value for Korsmeyer-Peppas (R2 = 0.998) model. A controlled release nano emulsion formulation was successfully formulated thatcould be a smart way for effective intranasal delivery of artemether to enhance the bioavailability by avoiding the hepatic first-pass metabolism.

show abstract

Quality by Design (QbD) based Formulation Optimization of Isoniazid Loaded Novel Nanostructured Lipid Carriers for Controlled Release Effect

Cited by 3 publications

References 39 publications

Accessing Properties of Molecular Compounds Involved in Cellular Metabolic Processes with Electron Paramagnetic Resonance, Raman Spectroscopy, and Differential Scanning Calorimetry

Accessing Properties of Molecular Compounds Involved in Cellular Metabolic Processes with Electron Paramagnetic Resonance, Raman Spectroscopy, and Differential Scanning Calorimetry

Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box-Behnken Design

Quality by Design (QbD) based Formulation Optimization of Artemether Loaded Mucoadhesive Nanoemulsion for Intranasal Delivery

Contact Info

Product

Resources

About