Quality Characteristics of Doenjang Prepared with Fermented Hwangchil (Dendropanax morbifera) Extract

Park, Seong-Eun; Seo, Seung-Ho; Yoo, Seung‐Min; Na, Chang-Su; Son, Hong-Seok

doi:10.3746/jkfn.2016.45.3.372

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have been conducted using fermented plant extracts with different techniques [ 14 ]. In our previous works [ 15 ], we optimized co-production of poly-γ-glutamic acid (γ-PGA) and γ-aminobutyric acid (GABA) in the presence of sodium-L-glutamate (MSG) in Dendropanax morbifera fermented by Bacillus subtilis HA (KCCM 10775P, patent strain) and Lactobacillus plantarum EJ2014 (KCCM 11545P, patent strain).…”

Section: Introductionmentioning

confidence: 99%

An in vivo immunomodulatory and anti-inflammatory study of fermented Dendropanax morbifera Léveille leaf extract

Birhanu

Kim

Hossain

et al. 2018

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundMedicinal plants represent a source of new drugs for the prevention and treatment of infectious diseases. Dendropanax morbifera Léveille is an economically and medicinally important subtropical tree that has various biological activities. However, its ability to affect immune responses in vivo is unknown. Hence, this study was designed to examine the immunomodulatory activity of fermented D. morbifera extract in BALB/c mice.Methodsfive-week-old female BALB/c mice were arranged in six groups and kept under a standard laboratory condition. Splenocyte counts were determined using the trypan blue dye exclusion method, and splenic lymphocyte proliferation was determined using concanavalin A and lipopolysaccharide (LPS). Flow cytometric analysis was performed to phenotype T-lymphocytes. Next, cytokine and immunoglobulin quantitation was performed using sandwich ELISA.ResultsThe results showed an increase in spleen cells by 71 and 67% in mice treated with 125 and 250 mg/kg of D. morbifera, respectively. In addition, splenocyte proliferation was increased 58.7% in response to concanavalin A treatment, while LPS treatment induced a 73.3% increase in mice treated with 125 mg/kg. T-cell phenotypic analysis indicated that D. morbifera-treated groups showed higher CD8a+, CD11b and CD3+ T-cell expression. However, the treatment groups showed suppression of IL-1α, Il-1β and IL-4. In addition, the IgG super-family was downregulated in a dose-dependent manner by 4.5% up to 43.7%.ConclusionsTaken together, we show that D. morbifera increases the number and proliferation of T- and B-lymphocytes. Moreover, these effects may play a role in boosting non-specific immunity, while suppressing proinflammatory cytokines and immunoglobulins after a single antigen exposure.

show abstract

Section: Introductionmentioning

confidence: 99%