Quality Control in Routine Clinical Chemistry

Lg, Whitby; Fl, Mitchell; Dw, Moss

doi:10.1016/s0065-2423(08)60112-2

Cited by 47 publications

(14 citation statements)

References 81 publications

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“…The mean (SD) activity was 954 (272) U/L, with a nonparametric 95% range of 505-1539 U/L. Because the method was changed from measurement of absorbance with a spectrophotometer to use of a microtiter plate reader during the course of the study, we examined the running mean of the results across time and also calculated and graphed the cumulative sum of the differences from the mean (cusum) (34 ). This plot (see Fig.…”

Section: Resultsmentioning

confidence: 99%

Butyrylcholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity

et al. 2006

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Background: Plasma cholinesterase activity is known to be correlated with plasma triglycerides, HDL-and LDLcholesterol, and other features of the metabolic syndrome. A role in triglyceride metabolism has been proposed. Genetic variants that decrease activity have been studied extensively, but the factors contributing to overall variation in the population are poorly understood. We studied plasma cholinesterase activity in a sample of 2200 adult twins to assess covariation with cardiovascular risk factors and components of the metabolic syndrome, to determine the degree of genetic effects on enzyme activity, and to search for quantitative trait loci affecting activity. Methods and Results: Cholinesterase activity was lower in women than in men before the age of 50, but increased to activity values similar to those in males after that age. There were highly significant correlations with variables associated with the metabolic syndrome: plasma triglyceride, HDL-and LDL-cholesterol, apolipoprotein B and E, urate, and insulin concentrations; ␥-glutamyltransferase and aspartate and alanine aminotransferase activities; body mass index; and blood pressure. The heritability of plasma cholinesterase activity was 65%. Linkage analysis with data from the dizygotic

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Section: Resultsmentioning

confidence: 99%

Butyrylcholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity

et al. 2006

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“…Table 6 summarises the precision for each method. The within-batch precision (coefficient of variation, CV) was determined by the difference between duplicate specimens as described by Whitby et al (1967). Overall precision was determined from repeated observations on the same specimen assayed at different times during the period of this investigation.…”

mentioning

confidence: 99%

“…Overall precision was determined from repeated observations on the same specimen assayed at different times during the period of this investigation. The CV for non-paired data was calculated in the usual manner (Whitby et al, 1967).…”

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confidence: 99%

A Comparative Study of Commercial Human and Bovine Albumin Preparations

et al. 1978

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SUMMARY A number of commercial human and bovine albumin preparations were compared using seven assay procedures, to assess their suitability as reference materials for albumin and total protein assays. The results indicate that before a particular commercial albumin preparation can be used for standardisation purposes, its suitability should be checked in several assay systems which measure a different functional aspect of the protein molecule. The measurement of extinction coefficient in the range 278-280 nm does not appear to be a valid measure of protein content if the albumin preparation is to be used for standardisation of immunochemical or dye-binding assays.

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“…Jeder dieser Teilschritte ist mit mehr oder weniger großen Fehlern behaftet. Hier dürften einige der Gründe dafür liegen, daß die Präzision der Analysenergebnisse mit der Einführung mechanischer Systeme nicht in dem erwarteten Maße zugenommen hat (1). Einige der oben genannten Teilschritte des Arbeitsablaufes können einer EDV-Anlage übertragen werden.…”

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