Quality control of the blood pressure phenotype in the European Project on Genes in Hypertension

Kuznetsova, Tatiana; Staessen, Jan A.; Kawecka‐Jaszcz, Kalina; Babeanu, Speranta; Casíglia, Edoardo; Filipovský, Jan; Nachev, C; Nikitin, Yu. P.; Peleskã, Jan; O’Brien, Eoin

doi:10.1097/00126097-200208000-00003

Cited by 101 publications

(128 citation statements)

References 22 publications

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“…We excluded 2310 (21.4%), because they were younger than 18 years at enrollment (n¼250), because their conventional BP had not been measured (n¼220), or because there were fewer than 10 daytime (n¼146) or 5 nighttime readings (n¼1983). The number of subjects statistically analyzed totaled 8494 and included: 2142 residents from Copenhagen, Denmark; 13 1124 from Noorderkempen, Belgium; 14 1317 from Ohasama, Japan; 15 1438 from Montevideo, Uruguay; 16 349 from the JingNing county, China; 17 1097 older men from Uppsala, Sweden; 18 165 subjects from Pilsen, the Czech Republic; 19 308 subjects from Kraków, Poland; 19 310 subjects from Padova, Italy; 19 and 244 subjects from Novosibirsk, the Russian Federation. 19,20 Supplementary Table S1 of the Data Supplement published online lists the average number of daytime and nighttime readings by cohort and for all cohorts combined.…”

Section: Study Populationmentioning

confidence: 99%

“…Conventional BP was measured by trained observers with a mercury sphygmomanometer, 13,14,[17][18][19][20] or with validated auscultatory 21,22 (USM-700F, UEDA Electronic Works, Tokyo, Japan) 15 or oscillometric (OMRON HEM-705CP, Omron Corporation, Tokyo, Japan) 16 devices, using the appropriate cuff size, with participants in the sitting [13][14][15][16][17]19,20 or supine 14 position. Conventional BP was the average of two consecutive readings obtained either at the person's home, 14,16,17,19,20 or at an examination center.…”

Section: Measurementsmentioning

confidence: 99%

“…Conventional BP was the average of two consecutive readings obtained either at the person's home, 14,16,17,19,20 or at an examination center. 13,15,18 We used portable BP monitors to obtain readings every 30 min throughout the whole day, 15 18 or an oscillometric technique (SpaceLabs 90202 and 90207, SpaceLabs Medical Inc., Redmond, WA, USA, and ABPM-630, Nippon Colin, Komaki, Japan) in the remaining cohorts.…”

Section: Measurementsmentioning

confidence: 99%

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Are blood pressure and diabetes additive or synergistic risk factors? Outcome in 8494 subjects randomly recruited from 10 populations

Sehestedt

Hansen

et al. 2011

Hypertens Res

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It remains unknown whether diabetes and high blood pressure (BP) are simply additive risk factors for cardiovascular outcome or whether they act synergistically and potentiate one another. We performed 24-h ambulatory BP monitoring in 8494 subjects (mean age, 54.6 years; 47.0% women; 6.9% diabetic patients) enrolled in prospective population studies in 10 countries. In multivariable-adjusted Cox regression, we assessed the additive as opposed to the synergistic effects of BP and diabetes in relation to a composite cardiovascular endpoint by testing the significance of appropriate interaction terms. During 10.6 years (median follow-up), 1066 participants had a cardiovascular complication. Diabetes mellitus as well as the 24-h ambulatory BP were independent and powerful predictors of the composite cardiovascular endpoint. However, there was no synergistic interaction between diabetes and 24-h, daytime, or nighttime, systolic or diastolic ambulatory BP (P for interaction, 0.07pPp0.97). The only exception was a borderline synergistic effect between diabetes and daytime diastolic BP in relation to the composite cardiovascular endpoint (P¼0.04). In diabetic patients, with normotension as the reference group, the adjusted hazard ratios for the cardiovascular endpoint were 1.35 (95% confidence interval (CI), 0.87-2.11) for white-coat hypertension, 1.78 (95% CI, 1.22-2.60) for masked hypertension and 2.44 (95% CI, 1.92-3.11) for sustained hypertension. The hazard ratios for non-diabetic subjects were not different from those of diabetic patients (P-values for interaction, 0.09pPp0.72).In conclusion, in a large international population-based database, both diabetes mellitus and BP contributed equally to the risk of cardiovascular complications without evidence for a synergistic effect.

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Section: Study Populationmentioning

confidence: 99%

Section: Measurementsmentioning

confidence: 99%

Section: Measurementsmentioning

confidence: 99%

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Are blood pressure and diabetes additive or synergistic risk factors? Outcome in 8494 subjects randomly recruited from 10 populations

Sehestedt

Hansen

et al. 2011

Hypertens Res

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“…For analysis, the 5 blood pressure readings obtained at baseline or at follow‐up were averaged. From baseline to follow‐up, we implemented a stringent quality control program described elsewhere 18, 19. Hypertension on conventional blood pressure measurement was a blood pressure ≥140 mm Hg systolic or 90 mm Hg diastolic.…”

Section: Methodsmentioning

confidence: 99%

Conventional and Ambulatory Blood Pressure as Predictors of Diastolic Left Ventricular Function in a Flemish Population

Wei

Yang

Thijs

et al. 2018

JAHA

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BackgroundNo longitudinal study compared associations of echocardiographic indexes of diastolic left ventricular function studies with conventional (CBP) and daytime ambulatory (ABP) blood pressure in the general population.Methods and ResultsIn 780 Flemish (mean age, 50.2 years; 51.7% women), we measured left atrial volume index (LAVI), peak velocities of the transmitral blood flow (E) and mitral annular movement (e′) in early diastole and E/e′ 9.6 years (median) after CBP and ABP. In adjusted models including CBP and ABP, we expressed associations per 10/5‐mm Hg systolic/diastolic blood pressure increments. LAVI and E/e′ were 0.65/0.40 mL/m2 and 0.17/0.09 greater with higher systolic/diastolic ABP (P≤0.028), but not with higher baseline CBP (P≥0.086). e′ was lower (P≤0.032) with higher diastolic CBP (−0.09 cm/s) and ABP (−0.19 cm/s). When we substituted baseline CBP by CBP recorded concurrently with echocardiography, LAVI and E/e′ remained 0.45/0.38 mL/m2 and 0.15/0.08 greater with baseline ABP (P≤0.036), while LAVI (+0.53 mL/m2) and E/e′ (+0.19) were also greater (P<0.001) in relation to concurrent systolic CBP. In categorized analyses of baseline data, sustained hypertension or masked hypertension compared with normotension or white‐coat hypertension was associated with greater LAVI (24.0 versus 22.6 mL/m2) and E/e′ (7.35 versus 6.91) and lower e′ (10.7 versus 11.6 cm/s; P≤0.006 for all) with no differences (P≥0.092) between normotension and white‐coat hypertension or between masked hypertension and sustained hypertension.Conclusions ABP is a long‐term predictor of diastolic left ventricular function, statistically outperforming distant but not concurrent CBP. Masked hypertension and sustained hypertension carry equal risk for deterioration of diastolic left ventricular function.

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“…9 In addition to blood pressure, several other intermediate or associated phenotypes, such as LVM, were measured. The epidemiological methods used in EPOGH have been previously described.…”

Section: General Outline Of the Studymentioning

confidence: 99%

Context-dependency of the relation between left ventricular mass and AGT gene variants

et al. 2004

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In the European Project on Genes in Hypertension (EPOGH), we investigated in three populations to what extent in a family-based study, left ventricular mass (LVM) was associated with the CÀ532T and GÀ6A polymorphisms in the angiotensinogen (AGT) gene. We randomly recruited 221 nuclear families (384 parents and 440 offspring) in Cracow (Poland), Novosibirsk (Russia), and Mirano (Italy). Echocardiographic LVM was indexed to body surface area, adjusted for covariables, and subjected to multivariate analyses, using generalized estimating equations and quantitative transmission disequilibrium tests in a population-based and family-based approach, respectively. We found significant differences between the two Slavic centres and Mirano in left ventricular mass index (LVMI) (94.9 vs 80.4 g/m 2 ), sodium excretion (229 vs 186 mmol/day), and the prevalence of the AGT À6A (55.7 vs 40.6%) and À532T (16.8 vs 9.4%) alleles. In population-based as well as in family-based analyses, we observed positive associations of LVMI and mean wall thickness (MWT) with the À532T allele in Slavic, but not in Italian male offspring. Furthermore, in Slavic male offspring, LVMI and MWT were significantly higher in carriers of the À532T/À6A haplotype than in those with the À532C/À6G or À532C/À6A allele combinations. In women, LVMI was neither associated with single AGT gene variants nor with the haplotypes (0.19oPo0.98). In Slavic offspring carrying the AGT À532C/À6G or À532C/À6A haplotypes, LVMI significantly increased with higher sodium excretion ( þ 3.5 g/m 2 /100 mmol; P ¼ 0.003), whereas such association was not present in À532T/À6A haplotype carriers (P-value for interaction 0.04). We found a positive association between LVMI and the AGT À532T allele due to increased MWT. This relation was observed in Slavic male offspring. It was therefore dependent on gender, age and ecogenetic context, and in addition it appeared to be modulated by the trophic effects of salt intake on LVM.

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Quality control of the blood pressure phenotype in the European Project on Genes in Hypertension

Cited by 101 publications

References 22 publications

Are blood pressure and diabetes additive or synergistic risk factors? Outcome in 8494 subjects randomly recruited from 10 populations

Are blood pressure and diabetes additive or synergistic risk factors? Outcome in 8494 subjects randomly recruited from 10 populations

Conventional and Ambulatory Blood Pressure as Predictors of Diastolic Left Ventricular Function in a Flemish Population

Context-dependency of the relation between left ventricular mass and AGT gene variants

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