2021
DOI: 10.1016/j.devcel.2021.02.009
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Quality control of the mitochondrion

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Cited by 248 publications
(174 citation statements)
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“…2 Whether basal mitophagy suppresses myocardial inflammatory signaling in the unstressed heart remains unknown. It is noteworthy that all currently defined mitophagy pathways are intrinsic to damaged mitochondria and recognize mitochondrial damage or dysfunction to facilitate lysosomal removal of damaged mitochondria via mitophagy or other mechanisms; 27 whereby participation of innate immune mechanisms in this process remains a (which was not certified by peer review) is the author/funder. All rights reserved.…”
Section: Induce Mitophagy; Andmentioning
confidence: 99%
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“…2 Whether basal mitophagy suppresses myocardial inflammatory signaling in the unstressed heart remains unknown. It is noteworthy that all currently defined mitophagy pathways are intrinsic to damaged mitochondria and recognize mitochondrial damage or dysfunction to facilitate lysosomal removal of damaged mitochondria via mitophagy or other mechanisms; 27 whereby participation of innate immune mechanisms in this process remains a (which was not certified by peer review) is the author/funder. All rights reserved.…”
Section: Induce Mitophagy; Andmentioning
confidence: 99%
“…Examination of mitochondrial turnover in cardiac myocytes reveals a half-life of ∼6-17 days as evaluated by conventional pulse chase assays 24, 25 , and contemporary analyses with maturation of mitoTimer fluorophore reveals that mitochondrial turnover slows down in the aging heart 26 . While mitochondrial protein quality control may proceed via multiple pathways, 27 turnover of mitochondria requires the autophagy-lysosome pathway by mitophagy 18 . Indeed, impairment of global macro-autophagy with inducible adult-onset cardiac myocyte-specific ablation of ATG5 28 or ATG7 29 , proteins essential for early steps in autophagosome formation, induces cardiomyopathy with appearance of damaged mitochondria on ultrastructural analyses.…”
Section: Introductionmentioning
confidence: 99%
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“…Autophagy plays an additional metabolic role via the process of mitophagy [86]. Mitochondria, referred to as the "powerhouses of the cell", are organelles that contain all the machinery required for oxidative phosphorylation and produce most of the cellular supply of ATP, the cell's main energy source [87].…”
Section: Autophagy In Neural Stem Cell Proliferation and Differentiationmentioning
confidence: 99%
“…If not repaired or removed in a timely manner, large numbers of damaged mitochondria will accumulate in the cell, increase cell burden, and cause loss of cellular function. In addition, the crucial role of mitochondria in apoptosis also requires that the quality of these organelles be strictly controlled to avoid cell death (Matthew et al, 2021). A cellular strategy known as mitophagy functions to remove damaged mitochondria.…”
Section: Introductionmentioning
confidence: 99%