Quality control procedures in the preparation of 2‐deoxy‐D‐[1‐¹¹C] glucose radiopharmaceutical

Abstract

Preparation and quality control of 2‐deoxy‐D‐[1‐11C] glucose (11C‐2DG, 1) have been accomplished by a combination of cation‐exchange and high performance liquid chromatography (HPLC) to give the radiopharmaceutical in greater than 99% radiochemical purity and an overall 25‐35% radiochemical yield in 45‐50 min. Quality control procedures utilizing GC and HPLC have been developed to determine not only chemical and radiochemical purity of the final product, but also to examine the reactants used and the products formed during the preparation of 1.

Routine production of 2‐deoxy‐D‐[1‐11C]glucose : An alternative

“…This method is more convenient than neutralisation with an anion-exchange resin in the HC03 form. In that case the resin is preferencially stirred in the acid solution counter ions through protonation, but it is too 3ions and passes and filtered off (6) to cope with the evolution of upon adsorption of formic acid. Packing the resin led in our hands to unacceptable losses of "C-2DG turbance of the resin bed.…”