Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part II: Efficacy and safety

Barnes, Joanne

doi:10.1046/j.1365-2125.2003.01811.x

Cited by 116 publications

(84 citation statements)

References 50 publications

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“…5 Dried root of Withania somnifera Linn called Winter cherry in English and Ashwagandha in Hindi has been used in Ayurvedic medicine for many centuries. Experimental studies show that the plant extract is effective in neuroprotection in cerebral ischemia 6 The extract of ashwagandha is effective against oxidative stress and prevents the cyclophosphamide induced toxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Extract Withania somnifera on Tolerance to Antiepileptic Effect of Phenobarbitone in Mice

Ekambaram¹

2015

JYP

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Objective: To evaluate neuroprotective and antioxidant properties in Phenobarbitone (PHB) induced tolerant effect of aqueous extract of withania somnifera (WS) in mice. Materials & Methods: Male Swiss albino mice were screened for hind limb tonic extension (HLTE). Animals were divided into 6 groups, Group 1 and 2 served as controls, which received vehicle and PHB (25 mg/kg, i.p.) respectively. Group 3 received PHB (25 mg/kg, i.p.) and after two hr induced to maximal electric shock (MES) at alternate day for 18 days, incidence of HLTE on two consecutive days taken as endpoint. Group 4, 5 and 6 MES was induced 2 hr following co-administration of PHB (25 mg/kg, i.p.) and WS (500, 750 and 1000 mg/kg p.o. respectively). At the end of 18 th day, mice behaviour tests were performed, after those animals were sacrificed by overdosing of anaesthesia and brain were collected for estimation of malondialdehyde (MDA) and reduced glutathione (GSH). Results: After WS treated (500 mg/kg) mice were showed 80% of tolerance effect which has similar to phenobarbitone treated mice. The higher dose treated of WS (750 and 1000 mg/kg) mice were showed maximum at 20% of the tolerance effect in MES induced epilepsy. MDA levels were decreased and GSH levels increased significantly. Higher dose of WS treated mice were showed significant improvement in cognitive functions. Conclusion: These findings suggests that aqueous extract of WS (750, 1000 mg/kg) adjuvant to PHB delay in development of tolerance and added advantage of prevention of cognitive impairment and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Extract Withania somnifera on Tolerance to Antiepileptic Effect of Phenobarbitone in Mice

Ekambaram¹

2015

JYP

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“…Neste âm-bito, a fitoterapia baseada na evidência (já praticada em alguns países, como a Alemanha) deve assumir lugar de destaque. Contudo, a elevada variabilidade nos constituintes das espécies leva a que produtos vindos de diferentes produtores e com diferentes lotes sejam distintos em composição, sendo a sua avaliação em ensaios clínicos dificultada (18) . É preciso saber selecionar as melhores fontes bibliográficas, com o maior grau de evidência científica possível.…”

Section: Discussionunclassified

“…The evidence-based phytotherapy (practiced in some countries, such as Germany) must be highlighted. Nevertheless, the great variability of some species' composition coming from different producers and with different batches make the finished product distinct in composition, thus difficult to study in clinical assays (18) . It is important to know how to select the best sources and the greatest evidence possible.…”

Section: Discussionmentioning

confidence: 99%

Potential herb-drug interactions found in a community pharmacy patients

Batista

Pinho

Castel‐Branco

et al. 2015

BBR

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33 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Potential herb-drug interactions found in a community pharmacy patients Potenciais interações plantas - medicamentos encontradas em utentes de uma farmácia comunitária AbstractPhytotherapy has always played a leading role in therapeutics. However, a strong knowledge of the risk-benefit relationship of herbal products by patients and health professionals is necessary. The goals of this study were to characterize the consumption pattern of medicinal plants in patients in a community pharmacy, identify potential herb-drug interactions, and establish a list of recommendations for health professionals and/or patients in order to prevent/minimize negative outcomes arising from these interactions. In a sample of 25 patients, 24 cases of potential herb-drug interactions were detected. Most of the cases corresponded to the simultaneous use of a conventional medication with Ginkgo. The recommendation list involved monitoring the effectiveness and safety of conventional therapy associated with the use of medicinal plants, with particular focus on clinical and laboratory monitoring of the occurrence of bleeding, blood pressure, glycaemia and liver function.The results indicate that there is still a lack of knowledge about the possible risks of herbal products, which may adversely affect patient's health. The pharmacist is in prime position to raise awareness in the population, avoiding harmful situations for the patient's health.Keywords: phytotherapy, herb-drug interactions, pharmacist. ResumoA fitoterapia desempenha um papel preponderante ao nível da terapêutica. Mas só um forte conhecimento da relação benefício-risco dos produtos à base de plantas, por parte dos doentes e profissionais de saúde, permite retirar um máximo benefício desta terapêutica.Foram objetivos deste trabalho a caracterização do padrão de consumo de plantas medicinais em utentes de uma farmácia comunitária, a identificação de potenciais interações planta-medicamento e a criação de uma lista de recomendações para o profissional de saúde e/ou doente, a fim de reduzir/evitar resultados clínicos negativos decorrentes da ocorrência dessas interações. Numa amostra de 25 utentes foram detetados 24 casos de potenciais interações planta-medicamento. A maioria dos casos correspondeu à toma concomitante de um medicamento convencional com Ginkgo. A lista de recomendações envolveu a monitorização da efetividade e segurança da terapêutica convencional associada ao uso de plantas medicinais, com destaque para a monitorização clínica e laboratorial da ocorrência de hemorragias, da pressão arterial, glicémia e função hepática. Os resultados obtidos indicam que há ainda uma falta de conhecimento quanto aos riscos dos produtos à base de plantas, que pode influenciar negativamente a saúde de qualquer doente. O farmacêutico está em situação privilegiada para a sensibilização da população, evitando situações prejudiciais para a saúde do doe...

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“…When patients abandon conventional treatments for alternative medicines they are at risk of exacerbation and chronic complications due to inadequate control of disease, adverse effects and drug interactions (Barnes, 2003). The high risk of complications and exacerbations can result in a higher number of emergency service visits and deaths (Jose et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Use of medicinal herbs by patients with severe asthma managed at a Referral Center

Mega

Santos

Souza‐Machado³

et al. 2011

Braz. J. Pharm. Sci.

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Asthma is a chronic inflammatory disease of the airways that may lead to limitations in regular activities, to hospitalizations and a decrease in quality of life. Adherence to drug treatment is crucial for control of the disease. The use of medicinal herbs can reduce adherence to prescriptions, as the medication may be replaced by infusions or herbal products. The objective of this study was to evaluate the frequency of use of traditional herbal medicine among severe asthmatics in Salvador. Information on use of homemade remedies was obtained through application of a questionnaire during patient visits to a referral center. We also collected data on economic and social aspects as well as disease control. One hundred and forty-four (91,1%) out of one hundred and fifty-eight patients evaluated used herbal medicines, but only 26.5% attributed improvement of asthma symptoms to this alternative treatment and only 8 had substituted a prescribed medication by herbal medicines. There was a trend towards lower adherence to prescription drug treatment in this group of patients. Despite the high frequency of use of medicinal herbs in our sample, there was no improvement in the asthma treatment in this population compared to non-users. Adherence to conventional drug treatment was satisfactory and there was neither reduction in asthma control nor increase in hospitalizations among the users of medicinal plants.Uniterms: Asthma/adherence to drug treatment. Medicinal herbs/use.A asma é uma enfermidade inflamatória crônica das vias aéreas que pode resultar em limitações nas atividades diárias, internações e prejuízo da qualidade de vida. A adesão ao tratamento medicamentoso é fundamental para o controle da doença. O uso de plantas medicinais pode reduzir a adesão ao tratamento prescrito, à medida que os medicamentos são substituídos por chás ou ervas. O objetivo deste estudo foi avaliar a frequência de uso de plantas medicinais entre asmáticos graves em Salvador. As informações sobre uso de remédios caseiros foram obtidas por meio de questionário durante a visita dos pacientes a um centro de referência. Foram coletados dados econômicos, sociais e de controle da doença. Cento e quarenta e quatro (91,1%) dos cento e cinqüenta e oito pacientes avaliados utilizavam plantas medicinais, dos quais apenas 26,5% atribuíam melhora dos sintomas da asma a este tratamento alternativo e somente 8 pacientes já haviam feito a substituição de medicamento por alguma planta medicinal. Houve tendência a menor adesão ao tratamento medicamentoso neste grupo de pacientes. Apesar da alta frequência do uso de plantas medicinais na nossa amostra, não houve melhora no tratamento da asma desta população em relação aos não-usuários. A adesão ao tratamento medicamentoso foi satisfatória, não havendo piora no controle da asma ou aumento em hospitalizações entre os usuários de plantas medicinais.Unitermos: Asma/adesão ao tratamento medicamentoso. Plantas medicinais/uso.

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Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part II: Efficacy and safety

Cited by 116 publications

References 50 publications

Effect of Aqueous Extract Withania somnifera on Tolerance to Antiepileptic Effect of Phenobarbitone in Mice

Effect of Aqueous Extract Withania somnifera on Tolerance to Antiepileptic Effect of Phenobarbitone in Mice

Potential herb-drug interactions found in a community pharmacy patients

Use of medicinal herbs by patients with severe asthma managed at a Referral Center

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