Quality evaluation and standardization of a traditional Unani formulation Jawarish-e-Amla Sada

Abstract

Background: Jawarish-e-Amla Sada (JAS) is a traditional Unani formulation commonly used for the clinical treatment of Zof-e-Meda (weakness of the stomach), Zof-e-Kabid (weakness of the liver), Zof-e-Qalb (weakness of the heart), Khafqan (palpitation), Nafkh-e-Shikam (flatulence in the stomach) and Is-Hal-e-Safrawi (biliary diarrhoea). It is a semisolid polyherbal preparation of six medicinal plants. Aims and Objectives: In the present research work an attempt has been made to establish the physicochemical, phytochemical and safety profile of JAS which may be useful for its quality control and standardization. Materials and Methods: Standardized operating procedure for the preparation of JAS was developed in accordance with National Formulary of Unani Medicine. The formulation was also subjected to preliminary phytochemical and physicochemical evaluation. Chemical characterization of the formulation was carried out on the basis of gallic acid content using a validated high-performance thin layer chromatographic method. Safety of the formulation was affirmed by conducting acute oral toxicity in mice. Results: Preliminary phytochemical, physicochemical and chromatographic profile of the formulation was established. The formulation was found safe up to an oral dose of 2 g/kg body weight in mice. Conclusion: Findings of the present work can be used as a reference standard by quality control/assurance laboratory of a pharmaceutical firm in order to have a proper quality check over its preparation and processing.

Medicinal plants in management of diabetes mellitus: an overview

“…In the Ayurvedic literature 'Sarangdhar Samhita', the concept of polyherbalism and combined extracts of plants are chosen rather than individual ones for the treatment of diabetes mellitus in the traditional system of medicine (Parasuraman et al, 2014). The Unani medicine has also achieved global acceptance due to the amazing clinical efficiency of the polyherbal formulations (Shailajan, 2015). In the majority of traditional systems, diabetes has been successfully managed by the polyherbal mixtures instead of a single herb because of the powerful synergism and less side effects (Yuan et al, 2017).…”

Untitled

“…[33] Various heavy metals were reported for their toxic effects above certain concentration. [34][35][36] In many parts of Asia, Europe, and the United States, the toxicity of heavy metals has been reported. [37,38] The uses of heavy metals for longer duration of time may lead to liver toxicity, renal damage, and teratogenic effects on the fetus.…”