Quality Evaluation of &lt;i&gt;Saposhnikoviae Radix&lt;/i&gt; (Differences between Wild-type and Cultivated Products)

Nishihara, Masakazu; Nukui, Keiji; Osumi, Yuko; Shiota, Hironori

doi:10.1248/yakushi.17-00208

Cited by 12 publications

(5 citation statements)

References 2 publications

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“…Under cultivation, roots of S. divaricata get more root branches, less annulus grains on the root top, light yellow brown color in cortical section of root, less brown oil spots and light odor (Feng et al, 2009). With respect to biochemisty, the cimcifugin contents were higher in the wild roots than in cultivated ones (Nishihara et al, 2018). In addition, wild roots of S. divaricata have clearly distinct section on head but cultivated roots have not.…”

Section: Discussionmentioning

confidence: 88%

“…The few available studies mainly reported on intraspecifi c biochemical diff erences in this species (Urbagarova et al, 2017;Men et al, 2018;Nishihara et al, 2018;Munkhoevna, 2019;Batsukh et al, 2019Batsukh et al, , 2020. Those studies found that intraspecifi c diff erences of S. divaricata root biochemistry is related to drought, soil factors and cultivation.…”

Section: Introductionmentioning

confidence: 99%

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Intraspecific differences of section on root head of siler (Saposhnikovia divariacata (Turcz.) Schischkin) in Mongolia

2022

Mong. J. Biol. Sci.

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The present study reveals intraspecifi c diff erences in root head sections of Saposhnikovia divaricata, and explains controlling factors. Root head sections have been divided into three categories, and these were compared to factors of geography, climate, fi re and human activities. The category clearly distinct section was predominantly recorded in Dornod and Selenge-Tuv-Arkhangai provinces but it showed lower frequency in Khentii and Sukhbaatar. With respect to administrative province, it was more common in Bayan-Uul, Sergelen, Dashbalbar and Tsagaan-Ovoo sites, Dornod province; in Dadal, Norovlin and Bayan-Khutag sites, Khentii province and Shaamar, Zuunduren and Altanbulag, Selenge province. The frequency of that category increased with more droughts during early summer and over lower aridity index and in pasturelands. It was higher on wild roots of S. divaricata than in cultivated ones. The frequency of category poorly recognized section was higher in Zuunkharaa, Nomgon and Siakhan sites, Selenge province while that of the category not-sectioned root head was higher on cultivated roots. The results of our study suggest that frequency of clearly distinct section on root head decreased by coldness, strong fi re frequency, trampling and/or gathering and cultivation.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Intraspecific differences of section on root head of siler (Saposhnikovia divariacata (Turcz.) Schischkin) in Mongolia

2022

Mong. J. Biol. Sci.

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“…According to this situation, the UPLC-UESI-Q Exactive Focus method was used in combination with available databases and literature data. According to ChemSpider (https://www.chemspider.com), the mass spectrometry database (https://www.massbank.jp), and many related Chinese herbal medicine research chemical components [26][27][28][29][30][31][32][33][34][35][36][37][38], the chemical database was established to identify the components of TTNC. e source of chemical components in TTNC was determined by the sample injection analysis of 6 botanical drugs and the ion flow extraction from the first-level high-resolution data.…”

Section: Uplc-uesi-q Exactive Focus Analysis Of Ttnc Extractsmentioning

confidence: 99%

Identification of Constituents and Exploring the Mechanism for Toutongning Capsule in the Treatment of Migraine

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Toutongning capsule (TTNC) is an effective and safe traditional Chinese medicine used in the treatment of migraine. In this present study, a multiscale strategy was used to systematically investigate the mechanism of TTNC in treating migraine, which contained UPLC-UESI-Q Exactive Focus network pharmacology and experimental verification. First, 88 compounds were identified by the UPLC-UESI-Q Exactive Focus method for TTNC. Then, the target fishing for these compounds was performed by means of an efficient drug similarity search tool. Third, a series of network pharmacology experiments were performed to predict the key compounds, targets, and pathways. They were protein-protein interaction (PPI), KEGG pathway enrichment analysis, and herbs-compounds-targets-pathways (H-C-T-P) network construction. As a result, 18 potential key compounds, 20 potential key targets, and 6 potential signaling pathways were obtained for TTNC in treatment with migraine. Finally, molecular docking and experimental were carried out to verify the key targets. In short, the results showed that TTNC is able to treat migraine through multiple components, multiple targets, and multiple pathways. This work may provide a theoretical basis for further research on the molecular mechanism of TTNC in the treatment of migraine.

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“…Most high-quality producing areas of wild S. divaricata are grassland areas with adverse environmental conditions, such as slight annual rainfall, arid climate, and large temperature difference between four seasons ( Men et al, 2018 ; Han et al, 2017 ). S. divaricata is characterized by “taproot” and “chrysanthemum heart” ( State Pharmacopoeia Committee, 2020 ), which is the typical plant feature in a drought condition ( Jiang et al, 2018 ; Nishihara et al, 2018 ). Studies showed that the main active components of S. divaricata were chromones and coumarins ( Okuyama et al, 2001 ; Batsukh et al, 2021 ; Zhao et al, 2010 ; Yang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…The current research on S. divaricata focuses on the pharmacological effects ( Zhao et al, 2010 ; Chun et al, 2016 ; Kong et al, 2013 ; Wang et al, 2017 ), separation and purification method of main components ( Nishihara et al, 2018 ; Zhang et al, 2008 ; Li et al, 2006 ), such as chromones and coumarins ( Ma et al, 2018 ; Sun et al, 2022 ; Yang et al, 2015 ; Chen et al, 2018 ), genome ( Liu et al, 2018 ), and antioxidant activity ( Kamino et al, 2016 ). However, the effects of S. divaricata on antioxidation and metabolites under drought stress have not been explored yet.…”

Section: Introductionmentioning

confidence: 99%

Ecological roles of secondary metabolites of Saposhnikovia divaricata in adaptation to drought stress

Cao

Shi

Shen

et al. 2022

PeerJ

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Saposhnikovia divaricata is a traditional Chinese herb that mainly grows in arid grasslands and strongly adapts to various stresses. Drought is not only a major abiotic stress factor but also a typical feature conducive to producing high-quality medicinal material. The present study investigated by treating S. divaricata plants with polyethylene glycol (PEG-6000). Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) identified 146 compounds from the roots of S. divaricata, among which seven primary metabolites and 28 secondary metabolites showed significant changes after drought treatment. UV-Vis spectrophotometer detected the activity of antioxidant enzymes and the content of superoxide anion (O2−.) and malondialdehyde (MDA). The differential primary metabolites revealed that drought promotes glycolysis, reducing primary metabolism and enhancing secondary metabolism. Meanwhile, the differential secondary metabolites showed an increase in the content of compounds upstream of the secondary metabolic pathway, and other glycosides and increased that of the corresponding aglycones. The activities of antioxidant enzymes and the content of O2−. and MDA shown different changes duing the drought treatment. These observations indicate that drought promotes the biosynthesis and transformation of the secondary metabolites and activity of antioxidant enzymes, improving plant adaptability. The present study also analyzed a few primary and secondary metabolites of S. divaricata under different degrees and durations of drought and speculated on the metabolic pathways in an arid environment. The findings indicate the biological nature, diversity, and complexity of secondary metabolites and the mechanisms of plant adaptation to ecological stress.

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Quality Evaluation of <i>Saposhnikoviae Radix</i> (Differences between Wild-type and Cultivated Products)

Cited by 12 publications

References 2 publications

Intraspecific differences of section on root head of siler (Saposhnikovia divariacata (Turcz.) Schischkin) in Mongolia

Intraspecific differences of section on root head of siler (Saposhnikovia divariacata (Turcz.) Schischkin) in Mongolia

Identification of Constituents and Exploring the Mechanism for Toutongning Capsule in the Treatment of Migraine

Ecological roles of secondary metabolites of Saposhnikovia divaricata in adaptation to drought stress

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