Quality evaluation of Polygala japonica through simultaneous determination of six bioactive triterpenoid saponins by HPLC-ELSD

Wang, Honglan; Gao, Jie; Zhu, Daling; Yu, Boyang

doi:10.1016/j.jpba.2006.11.012

Cited by 30 publications

(10 citation statements)

References 11 publications

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“…Although no pharmacological reports are found on astersaponins, triterpenoid saponins are often considered as expectorants, such as platycodins (from Platycodon grandiflorus) (Ryu et al, 2014;Song and Qi, 2006) and onjisaponins (from Polygala tenuifolia) (Wang et al, 2007;Peng and Xu, 1998). In this way, astersaponins contained in RA may be the main constituents responsible for dispelling phlegm, which can reduce airway inflammation and relieve cough.…”

Section: Discussionmentioning

confidence: 99%

Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus

Cheng

Xiang

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus

Cheng

Xiang

et al. 2015

Journal of Ethnopharmacology

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“…However, as detectors are very crucial in HPLC analysis, they are expected to possess some qualities which include sensitivity, linearity in a wide range of sample, reproducibility in the response, stability to changes in flow, and environmental parameters and capability of detection in a small volume of sample [190]. In general, the most frequently used detectors for the analysis of HMP are the UV-Vis [71, 80] and ELSD [75, 192–194]. …”

Section: High Performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Review: DNA Barcoding and Chromatography Fingerprints for the Authentication of Botanicals in Herbal Medicinal Products

Abubakar

Salleh²,

Shamsir³

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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In the last two decades, there has been a tremendous increase in the global use of herbal medicinal products (HMPs) due to their claimed health benefits. This has led to increase in their demand and consequently, also, resulted in massive adulteration. This is due to the fact that most of the traditional methods cannot identify closely related species in a process product form. Therefore the urgent need for simple and rapid identification methods resulted in the discovery of a novel technique. DNA barcoding is a process that uses short DNA sequence from the standard genome for species identification. This technique is reliable and is not affected by external factors such as climates, age, or plant part. The difficulties in isolation of DNA of high quality in addition to other factors are among the challenges encountered using the DNA barcoding in the authentication of HMP. These limitations indicated that using DNA barcoding alone may ineffectively authenticate the HMP. Therefore, the combination of DNA barcoding with chromatographic fingerprint, a popular and generally accepted technique for the assessment and quality control of HMP, will offer an efficient solution to effectively evaluate the authenticity and quality consistency of HMP. Detailed and quality information about the main composition of the HMPs will help to ascertain their efficacy and safety as these are very important for quality control.

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“…Based on laboratory studies and clinical practice, P. tenuifolia possesses various biological and therapeutic actions and functions as a mucolytic, tonic, sedative, antipsychotic, and expectorant [ 14 , 18 , 19 ]. Phytochemical studies of the dried roots of P. tenuifolia revealed that saponins, xanthones, and oligosaccharides are the major and bioactive secondary metabolites [ 20 , 21 , 22 ]. Saponins are considered active ingredients of expectorants, antitussives, and short-term memory enhancers [ 19 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

UPLC Quantitative Analysis of Multi-Components by Single Marker and Quality Evaluation of Polygala tenuifolia Wild. Extracts

Mao

Zhao

et al. 2017

Molecules

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The quality control of Polygala tenuifolia Wild. is a major challenge in its clinical application. In this paper, a new strategy for the quality evaluation of P. tenuifolia extracts was verified through reverse-phase ultra-performance liquid chromatography (UPLC). The quantitative analysis of multi-components by a single marker (QAMS) was conducted with 3,6′-disinapoyl sucrose as an internal reference substance. Eight components (i.e., sibiricose A5, sibiricose A6, glomeratose A, tenuifoliside A, tenuifoliside B, tenuifoliside C, sibiricaxanthone B, and polygalaxanthone III) were determined based on the relative correction factors. The concentrations of these components were also determined by applying a conventional external standard method. The cosine value confirmed the consistency of the two methods (cosine ratio value >0.999920). Hierarchical cluster analysis, radar plots, and discriminant analysis were performed to classify 23 batches of P. tenuifolia extracts from Shanxi, Hebei, and Shaanxi in China. Results revealed that QAMS combined with radar plots and multivariate data analysis could accurately measure and clearly distinguish the different quality samples of P. tenuifolia. Hence, QAMS is a feasible and promising method for the quality control of P. tenuifolia.

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Quality evaluation of Polygala japonica through simultaneous determination of six bioactive triterpenoid saponins by HPLC-ELSD

Cited by 30 publications

References 11 publications

Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus

Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus

Review: DNA Barcoding and Chromatography Fingerprints for the Authentication of Botanicals in Herbal Medicinal Products

UPLC Quantitative Analysis of Multi-Components by Single Marker and Quality Evaluation of Polygala tenuifolia Wild. Extracts

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