This chapter is focused on the role played by the blue economy in modern economies, which is associated with building resilience in uncertain situations. This chapter, using the quintuple innovation helix framework, aims to approach holistically the urgent function and role of the blue economy for environmental sustainability and conservation of marine resources and ecosystems focused on the potential for achieving economic and social goals for propelling our world towards the ideals for achieving sustainable development and growth and achieving inclusiveness in economies with equal opportunities for all. Throughout the analysis of the chapter, several critical concepts are introduced. Factors such as cooperation on national and international scales, new technologies, and access to financing instruments empower the blue economy to enhance its resilience and grasp opportunities while addressing dangers associated with the risks of the new era, such as climate change, natural and marine resources limitations, and social disparities.