Quality of cementing in hemiarthroplasty for elderly neck of femur fractures does not affect short term functional outcomes

Lee, Wu Chean; Ng, Poh Hwee Julia; Wu, Tianyi; Khoo, Kah Ming Sebastian; Tan, Tong Leng; Ho, Wei Loong Sean

doi:10.1007/s00402-024-05382-7

Arch Orthop Trauma Surg

2024

DOI: 10.1007/s00402-024-05382-7

|View full text |Cite

Quality of cementing in hemiarthroplasty for elderly neck of femur fractures does not affect short term functional outcomes

Wu Chean Lee,

Poh Hwee Julia Ng,

Tianyi Wu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2025

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Zhu,

Kim,

Lee

et al. 2025

Advanced Materials

View full text Add to dashboard Cite

Cancer immunotherapy, specifically Chimeric Antigen Receptor (CAR)‐T cell therapy, represents a significant breakthrough in treating cancers. Despite its success in hematological cancers, CAR‐T exhibits limited efficacy in solid tumors, which account for more than 90% of all cancers. Solid tumors commonly present unique challenges, including antigen heterogeneity and complex tumor microenvironment (TME). To address these, efforts are being made through improvements in CAR design and the development of advanced validation platforms. While efficacy is limited, some solid tumor types, such as neuroblastoma and gastrointestinal cancers, have shown responsiveness to CAR‐T therapy in recent clinical trials. In this review, it is first examined both experimental and computational strategies, such as protein engineering coupled with machine learning, developed to enhance T cell specificity. The challenges and methods associated with T cell delivery and in vivo reprogramming in solid tumors is discussed. It is also explored the advancements in engineered organoid systems, which are emerging as high‐fidelity in vitro models that closely mimic the complex human TME and serve as a validation platform for CAR discovery. Collectively, these innovative engineering strategies offer the potential to revolutionize the next generation of CAR‐T therapy, ultimately paving the way for more effective treatments in solid tumors.

show abstract

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Zhu,

Kim,

Lee

et al. 2025

Advanced Materials

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Quality of cementing in hemiarthroplasty for elderly neck of femur fractures does not affect short term functional outcomes

Cited by 1 publication

References 30 publications

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Contact Info

Product

Resources

About