Quality of life across chemotherapy lines in patients with advanced colorectal cancer: a prospective single-center observational study

Mayrbäurl, Beate; Giesinger, Johannes M.; Burgstaller, Sonja; Piringer, Gudrun; Holzner, Bernhard; Thaler, Josef

doi:10.1007/s00520-015-2828-0

Cited by 37 publications

(41 citation statements)

References 25 publications

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“…When discussing the relationship between the tumour-specific effects and symptoms, most of the respondents spontaneously stated that tumour response and symptom control tend to go in parallel: When an objective response is possible, the patient will also feel better as regards PS, QoL and well-being in general. Chemotherapy studies support this view, at least in first-line treatments, as objective responses often are accompanied by improvements in HRQoL [5,15].…”

Section: Discussionmentioning

confidence: 95%

“…Chemotherapy and targeted therapies are nowadays a mainstay in the treatment of disseminated cancers, as they may provide both life prolongation and symptom control, resulting in better health-related quality of life (HRQoL). As regards life prolongation, this is mainly true for first-, and second-line treatments, whereas further treatments may or may not give clear-cut benefits [1][2][3][4][5][6] and modern palliative treatment is rather expensive [7]. There is even a common perception that palliative chemotherapy treatments are used too generously to cancer patients at the end-of-life, with no obvious indications [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Does palliative chemotherapy provide a palliative effect on symptoms in late palliative stages? An interview study with oncologists

Strang

Bergqvist

2017

Acta Oncologica

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Does palliative chemotherapy provide a palliative effect on symptoms in late palliative stages? An interview study with oncologists

Strang

Bergqvist

2017

Acta Oncologica

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“…In addition, the quality of life was deteriorated across time, thus it was found large differences between patients with and without a treatment response for pain (19.0 vs. 37.2 points) and appetite loss (17.4 vs. 32.7 points). [10] Another research conducted with 100 patients with gastrointestinal, breast, lung and ovarian carcinoma evaluated the impact of chemotherapy on its physical or non-physical side effects. Patients indicated the negative impact on the family or spouse, alopecia, fatigue, and negative impact on work or domestic activities, on social and sexual life.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy treatment: Colorectal cancer patients’ perception

Benavente¹,

Costa²

2018

JNEP

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Background and objective: The chemotherapy cause greater impact in the physical and emotional sphere and in the experience of the symptoms. Thus, knowing the perception of these patients, is necessary to obtain subsidies that may direct the implementation of effective interventions for the management of adverse events and the support offering regarding the experience of the disease and treatment, with better impact on the quality of life. The objective of this study was to explore the perception of colorectal cancer patients regarding the chemotherapy treatment. Methods: It is a qualitative study, with content analysis based in Bardin. The sample was composed by 100 patients under chemotherapy treatment for colorectal cancer, who were enrolled in A.C. Camargo Cancer Center, São Paulo, Brazil. The data were collected using an interview about the perception of patients concerning chemotherapy. The interviews were audio recorded. For the analysis, we followed three steps: transcription, codification, and answers categorization. Results: The perceptions of the patients regarding chemotherapy were grouped into four categories: "negative experience", "necessary for disease control", "healing treatment" and "positive experience". The most cited was the negative experience, then, they referred worsening in the emotional level, since they reported sadness, loss of will to perform daily activities, side effects of drugs (hair loss, nausea, diarrhea), and other factors, as well as auxiliary activities necessary to receive treatment. Conclusions: For patients with colorectal cancer, the chemotherapy treatment causes negative experiences that could contribute for abandoning the treatment. However, they refer to be more strengthened and that they have developed the capability of learning through a painful experience as the chemotherapy. Nurses are responsible for valuing the patient's perception in order to make that his/her experience of illness and treatment possible to be reversed in a positive way, so they can have a better quality of life.

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“…Indeed, studies have found that fatigue is prevalent during chemotherapy regimens with alkylating agents, antimetabolites, taxanes, vinca‐alkaloids and platinum compounds (Honea et al., ; Kim, Oh, Lee, Kim, & Kim, ; Williams, Balabagno, et al., ; Zabernigg et al., ). Further, higher fatigue severity has been found to be related to chemotherapy dose intensity (Honea et al., ) and/or to the administration of multiple lines of chemotherapy (Mayrbaurl et al, ; Zabernigg et al, ). In contrast, a study by Hickok et al.…”

Section: Introductionmentioning

confidence: 99%